Dementia with Lewy Bodies: A Clinicopathologic Series of False-positive Cases

Netherlands Brain Bank

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled retrospectively from the Netherlands Brain Bank when they met the clinical criteria of probable DLB, but with a pathologic diagnosis other than DLB or Parkinson's disease dementia. Twenty-two false-positive cases were selected. Alzheimer disease with or without copathology was the most common (64%) pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical clinical signs for DLB were present in almost half of the cases and could be a trigger to consider other diagnoses than DLB. Additional diagnostic examinations, feedback of pathologic diagnosis, and the creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases.

Original languageEnglish
JournalAlzheimer Disease and Associated Disorders
DOIs
Publication statusPublished - 1 Jan 2019

Cite this

@article{0dfc6255f8b14919918abec4b461cb19,
title = "Dementia with Lewy Bodies: A Clinicopathologic Series of False-positive Cases",
abstract = "Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled retrospectively from the Netherlands Brain Bank when they met the clinical criteria of probable DLB, but with a pathologic diagnosis other than DLB or Parkinson's disease dementia. Twenty-two false-positive cases were selected. Alzheimer disease with or without copathology was the most common (64{\%}) pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical clinical signs for DLB were present in almost half of the cases and could be a trigger to consider other diagnoses than DLB. Additional diagnostic examinations, feedback of pathologic diagnosis, and the creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases.",
keywords = "atypical clinical signs, dementia with Lewy bodies, false-positive cases, pathology",
author = "{Netherlands Brain Bank} and Vergouw, {Leonie J.M.} and Marler, {Luca P.} and {Van De Berg}, {Wilma D.J.} and Rozemuller, {Annemieke J.M.} and {De Jong}, {Frank Jan}",
year = "2019",
month = "1",
day = "1",
doi = "10.1097/WAD.0000000000000308",
language = "English",
journal = "Alzheimer Disease and Associated Disorders",
issn = "0893-0341",
publisher = "Lippincott Williams and Wilkins",

}

Dementia with Lewy Bodies : A Clinicopathologic Series of False-positive Cases. / Netherlands Brain Bank.

In: Alzheimer Disease and Associated Disorders, 01.01.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Dementia with Lewy Bodies

T2 - A Clinicopathologic Series of False-positive Cases

AU - Netherlands Brain Bank

AU - Vergouw, Leonie J.M.

AU - Marler, Luca P.

AU - Van De Berg, Wilma D.J.

AU - Rozemuller, Annemieke J.M.

AU - De Jong, Frank Jan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled retrospectively from the Netherlands Brain Bank when they met the clinical criteria of probable DLB, but with a pathologic diagnosis other than DLB or Parkinson's disease dementia. Twenty-two false-positive cases were selected. Alzheimer disease with or without copathology was the most common (64%) pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical clinical signs for DLB were present in almost half of the cases and could be a trigger to consider other diagnoses than DLB. Additional diagnostic examinations, feedback of pathologic diagnosis, and the creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases.

AB - Diagnosing dementia with Lewy bodies (DLB) is challenging as symptoms are heterogenous and not specific to the disease. Here we present a clinicopathologic series of false-positive DLB cases. Patients were enrolled retrospectively from the Netherlands Brain Bank when they met the clinical criteria of probable DLB, but with a pathologic diagnosis other than DLB or Parkinson's disease dementia. Twenty-two false-positive cases were selected. Alzheimer disease with or without copathology was the most common (64%) pathologic diagnosis. Other pathologic diagnoses, such as frontotemporal dementia, multiple-system atrophy, Creutzfeldt-Jakob disease, and autoimmune encephalitis, were also encountered. Atypical clinical signs for DLB were present in almost half of the cases and could be a trigger to consider other diagnoses than DLB. Additional diagnostic examinations, feedback of pathologic diagnosis, and the creation of a set of clinical features that are indicative of other conditions, could reduce the amount of false-positive DLB cases.

KW - atypical clinical signs

KW - dementia with Lewy bodies

KW - false-positive cases

KW - pathology

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M3 - Article

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