Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study

I W M van Uden, A G W van Norden, K F de Laat, L J B van Oudheusden, R A R Gons, I Tendolkar, M P Zwiers, F-E de Leeuw

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of SVD in 503 participants with symptomatic cerebral SVD. Methods. Patients underwent FLAIR and T1 scanning. Depressive symptoms were assessed with structured questionnaires; amygdala and WML were manually segmented. The relation between amygdala volume and LODS/EODS was investigated and adjusted for age, sex, intracranial volume, and SVD. Results. Patients with LODS had a significantly lower left amygdala volume than those without (P = 0.02), independent of SVD. Each decrease of total amygdala volume (by mL) was related to an increased risk of LODS (OR = 1.77; 95% CI 1.02-3.08; P = 0.04). Conclusion. Lower left amygdala volume is associated with LODS, independent of SVD. This may suggest differential mechanisms, in which individuals with a small amygdala might be vulnerable to develop LODS.

Original languageEnglish
Pages (from-to)647869
JournalExperimental Aging Research
Volume2011
DOIs
Publication statusPublished - 2011

Cite this

van Uden, I. W. M., van Norden, A. G. W., de Laat, K. F., van Oudheusden, L. J. B., Gons, R. A. R., Tendolkar, I., ... de Leeuw, F-E. (2011). Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study. Experimental Aging Research, 2011, 647869. https://doi.org/10.4061/2011/647869
van Uden, I W M ; van Norden, A G W ; de Laat, K F ; van Oudheusden, L J B ; Gons, R A R ; Tendolkar, I ; Zwiers, M P ; de Leeuw, F-E. / Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease : The RUN DMC Study. In: Experimental Aging Research. 2011 ; Vol. 2011. pp. 647869.
@article{d300d0b98bb647c59c1b68109ff87be0,
title = "Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study",
abstract = "Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of SVD in 503 participants with symptomatic cerebral SVD. Methods. Patients underwent FLAIR and T1 scanning. Depressive symptoms were assessed with structured questionnaires; amygdala and WML were manually segmented. The relation between amygdala volume and LODS/EODS was investigated and adjusted for age, sex, intracranial volume, and SVD. Results. Patients with LODS had a significantly lower left amygdala volume than those without (P = 0.02), independent of SVD. Each decrease of total amygdala volume (by mL) was related to an increased risk of LODS (OR = 1.77; 95{\%} CI 1.02-3.08; P = 0.04). Conclusion. Lower left amygdala volume is associated with LODS, independent of SVD. This may suggest differential mechanisms, in which individuals with a small amygdala might be vulnerable to develop LODS.",
author = "{van Uden}, {I W M} and {van Norden}, {A G W} and {de Laat}, {K F} and {van Oudheusden}, {L J B} and Gons, {R A R} and I Tendolkar and Zwiers, {M P} and {de Leeuw}, F-E",
year = "2011",
doi = "10.4061/2011/647869",
language = "English",
volume = "2011",
pages = "647869",
journal = "Experimental Aging Research",
issn = "0361-073X",
publisher = "Taylor and Francis Ltd.",

}

van Uden, IWM, van Norden, AGW, de Laat, KF, van Oudheusden, LJB, Gons, RAR, Tendolkar, I, Zwiers, MP & de Leeuw, F-E 2011, 'Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study' Experimental Aging Research, vol. 2011, pp. 647869. https://doi.org/10.4061/2011/647869

Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease : The RUN DMC Study. / van Uden, I W M; van Norden, A G W; de Laat, K F; van Oudheusden, L J B; Gons, R A R; Tendolkar, I; Zwiers, M P; de Leeuw, F-E.

In: Experimental Aging Research, Vol. 2011, 2011, p. 647869.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease

T2 - The RUN DMC Study

AU - van Uden, I W M

AU - van Norden, A G W

AU - de Laat, K F

AU - van Oudheusden, L J B

AU - Gons, R A R

AU - Tendolkar, I

AU - Zwiers, M P

AU - de Leeuw, F-E

PY - 2011

Y1 - 2011

N2 - Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of SVD in 503 participants with symptomatic cerebral SVD. Methods. Patients underwent FLAIR and T1 scanning. Depressive symptoms were assessed with structured questionnaires; amygdala and WML were manually segmented. The relation between amygdala volume and LODS/EODS was investigated and adjusted for age, sex, intracranial volume, and SVD. Results. Patients with LODS had a significantly lower left amygdala volume than those without (P = 0.02), independent of SVD. Each decrease of total amygdala volume (by mL) was related to an increased risk of LODS (OR = 1.77; 95% CI 1.02-3.08; P = 0.04). Conclusion. Lower left amygdala volume is associated with LODS, independent of SVD. This may suggest differential mechanisms, in which individuals with a small amygdala might be vulnerable to develop LODS.

AB - Introduction. Late onset depressive symptoms (LODSs) frequently occur in elderly with cerebral small vessel disease (SVD). SVD cannot fully explain LODS; a contributing factor could be amygdala volume. We investigated the relation between amygdala volume and LODS, independent of SVD in 503 participants with symptomatic cerebral SVD. Methods. Patients underwent FLAIR and T1 scanning. Depressive symptoms were assessed with structured questionnaires; amygdala and WML were manually segmented. The relation between amygdala volume and LODS/EODS was investigated and adjusted for age, sex, intracranial volume, and SVD. Results. Patients with LODS had a significantly lower left amygdala volume than those without (P = 0.02), independent of SVD. Each decrease of total amygdala volume (by mL) was related to an increased risk of LODS (OR = 1.77; 95% CI 1.02-3.08; P = 0.04). Conclusion. Lower left amygdala volume is associated with LODS, independent of SVD. This may suggest differential mechanisms, in which individuals with a small amygdala might be vulnerable to develop LODS.

U2 - 10.4061/2011/647869

DO - 10.4061/2011/647869

M3 - Article

VL - 2011

SP - 647869

JO - Experimental Aging Research

JF - Experimental Aging Research

SN - 0361-073X

ER -