Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor

R. al Hussainy; J. Verbeek; D. van der Born; A.H. Braker; J.E. Leysen; R.J. Knol; J. Booij; J.D.M. Herscheid

doi:10.1021/jm1009956

Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor

R. al Hussainy, J. Verbeek, D. van der Born, A.H. Braker, J.E. Leysen, R.J. Knol, J. Booij, J.D.M. Herscheid

Radiology and nuclear medicine

Research output: Contribution to journal › Article › Academic › peer-review

Original language	Undefined/Unknown
Pages (from-to)	3480-3491
Journal	Journal of Medicinal Chemistry
Volume	54
Issue number	10
DOIs	https://doi.org/10.1021/jm1009956
Publication status	Published - 2011

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10.1021/jm1009956

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al Hussainy, R., Verbeek, J., van der Born, D., Braker, A. H., Leysen, J. E., Knol, R. J., Booij, J., & Herscheid, J. D. M. (2011). Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor. Journal of Medicinal Chemistry, 54(10), 3480-3491. https://doi.org/10.1021/jm1009956

al Hussainy, R. ; Verbeek, J. ; van der Born, D. et al. / Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor. In: Journal of Medicinal Chemistry. 2011 ; Vol. 54, No. 10. pp. 3480-3491.

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author = "{al Hussainy}, R. and J. Verbeek and {van der Born}, D. and A.H. Braker and J.E. Leysen and R.J. Knol and J. Booij and J.D.M. Herscheid",

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al Hussainy, R, Verbeek, J, van der Born, D, Braker, AH, Leysen, JE, Knol, RJ, Booij, J & Herscheid, JDM 2011, 'Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor', Journal of Medicinal Chemistry, vol. 54, no. 10, pp. 3480-3491. https://doi.org/10.1021/jm1009956

Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor. / al Hussainy, R.; Verbeek, J.; van der Born, D. et al.

In: Journal of Medicinal Chemistry, Vol. 54, No. 10, 2011, p. 3480-3491.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Braker, A.H.

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AU - Knol, R.J.

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AU - Herscheid, J.D.M.

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al Hussainy R, Verbeek J, van der Born D, Braker AH, Leysen JE, Knol RJ et al. Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexa necarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT(1A) Receptor. Journal of Medicinal Chemistry. 2011;54(10):3480-3491. doi: 10.1021/jm1009956