Developing a core outcome domain set to assessing effectiveness of interdisciplinary multimodal pain therapy: The VAPAIN consensus statement on core outcome domains

Ulrike Kaiser, Christian Kopkow, Stefanie Deckert, Katrin Neustadt, Lena Jacobi, Paul Cameron, Valerio de Angelis, Christian Apfelbacher, Bernhard Arnold, Judy Birch, Anna Bjarnegård, Sandra Christiansen, Amanda C de C Williams, Gudrun Gossrau, Andrea Heinks, Michael Hüppe, Henri Kiers, Ursula Kleinert, Paolo Martelletti, Lance McCracken & 13 others Nelleke de Meij, Bernd Nagel, Jo Nijs, Heike Norda, Jasvinder A. Singh, Ellen Spengler, Caroline B. Terwee, Peter Tugwell, Johan W. S. Vlaeyen, Heike Wandrey, Edmund Neugebauer, Rainer Sabatowski, Jochen Schmitt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Interdisciplinary multimodal pain therapy (IMPT) is a biopsychosocial treatment approach for patients with chronic pain that comprises at least psychological and physiotherapeutic interventions. Core outcome sets (COSs) are currently developed in different medical fields to standardize and improve the selection of outcome domains, and measurement instruments in clinical trials, to make trial results meaningful, to pool trial results, and to allow indirect comparison between interventions. The objective of this study was to develop a COS of patient-relevant outcome domains for chronic pain in IMPT clinical trials. An international, multiprofessional panel (patient representatives [n = 5], physicians specialized in pain medicine [n = 5], physiotherapists [n = 5], clinical psychologists [n = 5], and methodological researchers [n = 5]) was recruited for a 3-stage consensus study, which consisted of a mixed-method approach comprising an exploratory systematic review, a preparing online survey to identify important outcome domains, a face-to-face consensus meeting to agree on COS domains, and a second online survey (Delphi) establishing agreement on definitions for the domains included. The panel agreed on the following 8 domains to be included into the COS for IMPT: pain intensity, pain frequency, physical activity, emotional wellbeing, satisfaction with social roles and activities, productivity (paid and unpaid, at home and at work, inclusive presentism and absenteeism), health-related quality of life, and patient's perception of treatment goal achievement. The complexity of chronic pain in a biopsychosocial context is reflected in the current recommendation and includes physical, mental, and social outcomes. In a subsequent step, measurement instruments will be identified via systematic reviews.
Original languageEnglish
Pages (from-to)673-683
JournalPain
Volume159
Issue number4
DOIs
Publication statusPublished - 2018

Cite this

Kaiser, Ulrike ; Kopkow, Christian ; Deckert, Stefanie ; Neustadt, Katrin ; Jacobi, Lena ; Cameron, Paul ; de Angelis, Valerio ; Apfelbacher, Christian ; Arnold, Bernhard ; Birch, Judy ; Bjarnegård, Anna ; Christiansen, Sandra ; C de C Williams, Amanda ; Gossrau, Gudrun ; Heinks, Andrea ; Hüppe, Michael ; Kiers, Henri ; Kleinert, Ursula ; Martelletti, Paolo ; McCracken, Lance ; de Meij, Nelleke ; Nagel, Bernd ; Nijs, Jo ; Norda, Heike ; Singh, Jasvinder A. ; Spengler, Ellen ; Terwee, Caroline B. ; Tugwell, Peter ; Vlaeyen, Johan W. S. ; Wandrey, Heike ; Neugebauer, Edmund ; Sabatowski, Rainer ; Schmitt, Jochen. / Developing a core outcome domain set to assessing effectiveness of interdisciplinary multimodal pain therapy: The VAPAIN consensus statement on core outcome domains. In: Pain. 2018 ; Vol. 159, No. 4. pp. 673-683.
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abstract = "Interdisciplinary multimodal pain therapy (IMPT) is a biopsychosocial treatment approach for patients with chronic pain that comprises at least psychological and physiotherapeutic interventions. Core outcome sets (COSs) are currently developed in different medical fields to standardize and improve the selection of outcome domains, and measurement instruments in clinical trials, to make trial results meaningful, to pool trial results, and to allow indirect comparison between interventions. The objective of this study was to develop a COS of patient-relevant outcome domains for chronic pain in IMPT clinical trials. An international, multiprofessional panel (patient representatives [n = 5], physicians specialized in pain medicine [n = 5], physiotherapists [n = 5], clinical psychologists [n = 5], and methodological researchers [n = 5]) was recruited for a 3-stage consensus study, which consisted of a mixed-method approach comprising an exploratory systematic review, a preparing online survey to identify important outcome domains, a face-to-face consensus meeting to agree on COS domains, and a second online survey (Delphi) establishing agreement on definitions for the domains included. The panel agreed on the following 8 domains to be included into the COS for IMPT: pain intensity, pain frequency, physical activity, emotional wellbeing, satisfaction with social roles and activities, productivity (paid and unpaid, at home and at work, inclusive presentism and absenteeism), health-related quality of life, and patient's perception of treatment goal achievement. The complexity of chronic pain in a biopsychosocial context is reflected in the current recommendation and includes physical, mental, and social outcomes. In a subsequent step, measurement instruments will be identified via systematic reviews.",
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author = "Ulrike Kaiser and Christian Kopkow and Stefanie Deckert and Katrin Neustadt and Lena Jacobi and Paul Cameron and {de Angelis}, Valerio and Christian Apfelbacher and Bernhard Arnold and Judy Birch and Anna Bjarneg{\aa}rd and Sandra Christiansen and {C de C Williams}, Amanda and Gudrun Gossrau and Andrea Heinks and Michael H{\"u}ppe and Henri Kiers and Ursula Kleinert and Paolo Martelletti and Lance McCracken and {de Meij}, Nelleke and Bernd Nagel and Jo Nijs and Heike Norda and Singh, {Jasvinder A.} and Ellen Spengler and Terwee, {Caroline B.} and Peter Tugwell and Vlaeyen, {Johan W. S.} and Heike Wandrey and Edmund Neugebauer and Rainer Sabatowski and Jochen Schmitt",
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doi = "10.1097/j.pain.0000000000001129",
language = "English",
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pages = "673--683",
journal = "Pain",
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}

Kaiser, U, Kopkow, C, Deckert, S, Neustadt, K, Jacobi, L, Cameron, P, de Angelis, V, Apfelbacher, C, Arnold, B, Birch, J, Bjarnegård, A, Christiansen, S, C de C Williams, A, Gossrau, G, Heinks, A, Hüppe, M, Kiers, H, Kleinert, U, Martelletti, P, McCracken, L, de Meij, N, Nagel, B, Nijs, J, Norda, H, Singh, JA, Spengler, E, Terwee, CB, Tugwell, P, Vlaeyen, JWS, Wandrey, H, Neugebauer, E, Sabatowski, R & Schmitt, J 2018, 'Developing a core outcome domain set to assessing effectiveness of interdisciplinary multimodal pain therapy: The VAPAIN consensus statement on core outcome domains' Pain, vol. 159, no. 4, pp. 673-683. https://doi.org/10.1097/j.pain.0000000000001129

Developing a core outcome domain set to assessing effectiveness of interdisciplinary multimodal pain therapy: The VAPAIN consensus statement on core outcome domains. / Kaiser, Ulrike; Kopkow, Christian; Deckert, Stefanie; Neustadt, Katrin; Jacobi, Lena; Cameron, Paul; de Angelis, Valerio; Apfelbacher, Christian; Arnold, Bernhard; Birch, Judy; Bjarnegård, Anna; Christiansen, Sandra; C de C Williams, Amanda; Gossrau, Gudrun; Heinks, Andrea; Hüppe, Michael; Kiers, Henri; Kleinert, Ursula; Martelletti, Paolo; McCracken, Lance; de Meij, Nelleke; Nagel, Bernd; Nijs, Jo; Norda, Heike; Singh, Jasvinder A.; Spengler, Ellen; Terwee, Caroline B.; Tugwell, Peter; Vlaeyen, Johan W. S.; Wandrey, Heike; Neugebauer, Edmund; Sabatowski, Rainer; Schmitt, Jochen.

In: Pain, Vol. 159, No. 4, 2018, p. 673-683.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Developing a core outcome domain set to assessing effectiveness of interdisciplinary multimodal pain therapy: The VAPAIN consensus statement on core outcome domains

AU - Kaiser, Ulrike

AU - Kopkow, Christian

AU - Deckert, Stefanie

AU - Neustadt, Katrin

AU - Jacobi, Lena

AU - Cameron, Paul

AU - de Angelis, Valerio

AU - Apfelbacher, Christian

AU - Arnold, Bernhard

AU - Birch, Judy

AU - Bjarnegård, Anna

AU - Christiansen, Sandra

AU - C de C Williams, Amanda

AU - Gossrau, Gudrun

AU - Heinks, Andrea

AU - Hüppe, Michael

AU - Kiers, Henri

AU - Kleinert, Ursula

AU - Martelletti, Paolo

AU - McCracken, Lance

AU - de Meij, Nelleke

AU - Nagel, Bernd

AU - Nijs, Jo

AU - Norda, Heike

AU - Singh, Jasvinder A.

AU - Spengler, Ellen

AU - Terwee, Caroline B.

AU - Tugwell, Peter

AU - Vlaeyen, Johan W. S.

AU - Wandrey, Heike

AU - Neugebauer, Edmund

AU - Sabatowski, Rainer

AU - Schmitt, Jochen

PY - 2018

Y1 - 2018

N2 - Interdisciplinary multimodal pain therapy (IMPT) is a biopsychosocial treatment approach for patients with chronic pain that comprises at least psychological and physiotherapeutic interventions. Core outcome sets (COSs) are currently developed in different medical fields to standardize and improve the selection of outcome domains, and measurement instruments in clinical trials, to make trial results meaningful, to pool trial results, and to allow indirect comparison between interventions. The objective of this study was to develop a COS of patient-relevant outcome domains for chronic pain in IMPT clinical trials. An international, multiprofessional panel (patient representatives [n = 5], physicians specialized in pain medicine [n = 5], physiotherapists [n = 5], clinical psychologists [n = 5], and methodological researchers [n = 5]) was recruited for a 3-stage consensus study, which consisted of a mixed-method approach comprising an exploratory systematic review, a preparing online survey to identify important outcome domains, a face-to-face consensus meeting to agree on COS domains, and a second online survey (Delphi) establishing agreement on definitions for the domains included. The panel agreed on the following 8 domains to be included into the COS for IMPT: pain intensity, pain frequency, physical activity, emotional wellbeing, satisfaction with social roles and activities, productivity (paid and unpaid, at home and at work, inclusive presentism and absenteeism), health-related quality of life, and patient's perception of treatment goal achievement. The complexity of chronic pain in a biopsychosocial context is reflected in the current recommendation and includes physical, mental, and social outcomes. In a subsequent step, measurement instruments will be identified via systematic reviews.

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KW - Chronic pain

KW - Interdisciplinary multimodal pain therapy

KW - Core outcome set

KW - Consensus process

KW - Outcome domains

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29300277

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