Development and Validation of the Vitiligo Extent Score (VES): an International Collaborative Initiative: Journal of Investigative Dermatology

N. van Geel, J. E. Lommerts, M.W. Bekkenk, A. Wolkerstorfer, C. A. C. Prinsen, V. Eleftheriadou, A. Taieb, M. Picardo, K. Ezzedine, R. Speeckaert

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The clinical assessment of vitiligo involves an estimation of the affected body surface area. The most commonly used method is the "palm of hand 1% rule" as integrated in the Vitiligo Area Scoring Index. However, this method can be challenging and time consuming. In this study, we introduce a global Vitiligo Extent Score (VES). In the first part of the study, this measurement instrument was developed and subsequently optimized during a pilot scoring session. In a subsequent stage, the inter-and intrarater reliability of the instrument were tested. Live scoring showed an excellent interrater reliability for the VES (intraclass correlation VES: 0.924 vs. Vitiligo Area Scoring Index: 0.846). Subsequent scoring on pictures was comparable with the live evaluation and demonstrated an excellent intrarater reliability. A high intraclass correlation for the VES (intraclass correlation VES: 0.923 vs. Vitiligo Area Scoring Index: 0.757) was also found in an additional subgroup of patients with extensive vitiligo. Moreover, user-friendliness and timing were scored very favorably. In conclusion, this measurement instrument allows us to monitor accurately and easily the affected body surface area in a standardized way. Moreover, our results provide evidence that the VES can be proposed as a promising tool to measure the vitiligo extent in clinical trials and in daily practice.
Original languageEnglish
Pages (from-to)978-984
Number of pages7
JournalJournal of Investigative Dermatology
Publication statusPublished - 2016

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