Development of composite outcomes for individual patient data (IPD) meta-analysis on the effects of diet and lifestyle in pregnancy: a Delphi survey: Bjog-an International Journal of Obstetrics and Gynaecology

E. Rogozinska, M. I. D'Amico, K. S. Khan, J. G. Cecatti, H. Teede, S. Yeo, C. A. Vinter, G. Rayanagoudar, R. Barakat, M. Perales, J. M. Dodd, R. Devlieger, A. Bogaerts, M. N. M. van Poppel, L. Haakstad, G. X. Shen, A. Shub, Riitta Luoto, T. I. Kinnunen, S. PhelanL. Poston, T. T. Scudeller, N. El Beltagy, S. N. Stafne, S. Tonstad, N. R. W. Geiker, A. E. Ruifrok, B. W. Mol, A. Coomarasamy, S. Thangaratinam, Pregnancy Int Weight Management

Research output: Contribution to journalArticleAcademicpeer-review


ObjectiveTo develop maternal, fetal, and neonatal composite outcomes relevant to the evaluation of diet and lifestyle interventions in pregnancy by individual patient data (IPD) meta-analysis. DesignDelphi survey. SettingThe International Weight Management in Pregnancy (i-WIP) collaborative network. Sample Twenty-six researchers from the i-WIP collaborative network from 11 countries. MethodsA two-generational Delphi survey involving members of the i-WIP collaborative network (26 members in 11 countries) was undertaken to prioritise the individual outcomes for their importance in clinical care. The final components of the composite outcomes were identified using pre-specified criteria. Main outcome measuresComposite outcomes considered to be important for the evaluation of the effect of diet and lifestyle in pregnancy. ResultsOf the 36 maternal outcomes, nine were prioritised and the following were included in the final composite: pre-eclampsia or pregnancy-induced hypertension, gestational diabetes mellitus (GDM), elective or emergency caesarean section, and preterm delivery. Of the 27 fetal and neonatal outcomes, nine were further evaluated, with the final composite consisting of intrauterine death, small for gestational age, large for gestational age, and admission to a neonatal intensive care unit (NICU). ConclusionsOur work has identified the components of maternal, fetal, and neonatal composite outcomes required for the assessment of diet and lifestyle interventions in pregnancy by IPD meta-analysis. Tweetable abstractComposite outcomes in IPD meta-analysis on diet and lifestyle in pregnancy.
Original languageEnglish
Pages (from-to)190-198
Number of pages9
JournalBJOG: An International Journal of Obstetrics & Gynaecology
Publication statusPublished - 2016

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