Development of multidrug-resistance convertors: Sense or nonsense?

Lia Van Zuylen; Kees Nooter; Alex Sparreboom; Jaap Verweij

doi:10.1023/A:1006487003814

Development of multidrug-resistance convertors: Sense or nonsense?

Lia Van Zuylen^*, Kees Nooter, Alex Sparreboom, Jaap Verweij

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

This review describes the clinical relevance of the two drug transporters P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) and the in vitro phenomenon which is referred to as multidrug resistance (MDR). The attempts to try to block these resistance mechanisms are summarized with specific attention for the intentionally designed 'second generation' MDR-convertors. Potential explanations of the limited clinical success rate are given and recommendations for the design of future studies provided.

Original language	English
Pages (from-to)	205-220
Number of pages	16
Journal	Investigational New Drugs
Volume	18
Issue number	3
DOIs	https://doi.org/10.1023/A:1006487003814
Publication status	Published - 1 Jan 2000
Externally published	Yes

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title = "Development of multidrug-resistance convertors: Sense or nonsense?",

abstract = "This review describes the clinical relevance of the two drug transporters P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) and the in vitro phenomenon which is referred to as multidrug resistance (MDR). The attempts to try to block these resistance mechanisms are summarized with specific attention for the intentionally designed 'second generation' MDR-convertors. Potential explanations of the limited clinical success rate are given and recommendations for the design of future studies provided.",

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AU - Van Zuylen, Lia

AU - Nooter, Kees

AU - Sparreboom, Alex

AU - Verweij, Jaap

PY - 2000/1/1

Y1 - 2000/1/1

N2 - This review describes the clinical relevance of the two drug transporters P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) and the in vitro phenomenon which is referred to as multidrug resistance (MDR). The attempts to try to block these resistance mechanisms are summarized with specific attention for the intentionally designed 'second generation' MDR-convertors. Potential explanations of the limited clinical success rate are given and recommendations for the design of future studies provided.

AB - This review describes the clinical relevance of the two drug transporters P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) and the in vitro phenomenon which is referred to as multidrug resistance (MDR). The attempts to try to block these resistance mechanisms are summarized with specific attention for the intentionally designed 'second generation' MDR-convertors. Potential explanations of the limited clinical success rate are given and recommendations for the design of future studies provided.

KW - Cancer

KW - MDR-convertors

KW - MRP

KW - Multidrug resistance

KW - P-glycoprotein

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M3 - Review article

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JO - Investigational New Drugs

JF - Investigational New Drugs

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ER -

Development of multidrug-resistance convertors: Sense or nonsense?

Abstract

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