Diagnosis of myocarditis: Current state and future perspectives

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Myocarditis, i.e. inflammation of the myocardium, is one of the leading causes of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important cause of symptoms such as chest pain, dyspnea and palpitations. The pathophysiological process of disease progression leading to DCM involves an ongoing inflammation as a result of a viral-induced auto-immune response or a persisting viral infection. It is therefore crucial to detect the disease early in its course and prevent persisting inflammation that may lead to DCM and end-stage heart failure. Because of the highly variable clinical presentation, ranging from mild symptoms to severe heart failure, and the limited available diagnostic tools, the evaluation of patients with suspected myocarditis represents an important clinical dilemma in cardiology. New approaches for the diagnosis of myocarditis are needed in order to improve recognition, to help unravel its pathophysiology, and to develop new therapeutic strategies to treat the disease. In this review, we give a comprehensive overview of the current diagnostic strategies for patients with suspected myocarditis, and demonstrate several new techniques that may help to improve the diagnostic work-up.

Original languageEnglish
Pages (from-to)211-219
Number of pages9
JournalInternational Journal of Cardiology
Volume191
DOIs
Publication statusPublished - 15 Jul 2015

Cite this

@article{741946534dda4b8582318ea6941095d4,
title = "Diagnosis of myocarditis: Current state and future perspectives",
abstract = "Myocarditis, i.e. inflammation of the myocardium, is one of the leading causes of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important cause of symptoms such as chest pain, dyspnea and palpitations. The pathophysiological process of disease progression leading to DCM involves an ongoing inflammation as a result of a viral-induced auto-immune response or a persisting viral infection. It is therefore crucial to detect the disease early in its course and prevent persisting inflammation that may lead to DCM and end-stage heart failure. Because of the highly variable clinical presentation, ranging from mild symptoms to severe heart failure, and the limited available diagnostic tools, the evaluation of patients with suspected myocarditis represents an important clinical dilemma in cardiology. New approaches for the diagnosis of myocarditis are needed in order to improve recognition, to help unravel its pathophysiology, and to develop new therapeutic strategies to treat the disease. In this review, we give a comprehensive overview of the current diagnostic strategies for patients with suspected myocarditis, and demonstrate several new techniques that may help to improve the diagnostic work-up.",
keywords = "Animals, Biomarkers, Cardiomyopathy, Dilated, Endocardium, Forecasting, Humans, Magnetic Resonance Imaging, Cine, Myocarditis, Journal Article, Review",
author = "P.S. Biesbroek and A.M. Beek and T. Germans and H.W.M. Niessen and {van Rossum}, A.C.",
note = "Copyright {\circledC} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
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language = "English",
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pages = "211--219",
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Diagnosis of myocarditis : Current state and future perspectives. / Biesbroek, P.S.; Beek, A.M.; Germans, T.; Niessen, H.W.M.; van Rossum, A.C.

In: International Journal of Cardiology, Vol. 191, 15.07.2015, p. 211-219.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Diagnosis of myocarditis

T2 - Current state and future perspectives

AU - Biesbroek, P.S.

AU - Beek, A.M.

AU - Germans, T.

AU - Niessen, H.W.M.

AU - van Rossum, A.C.

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/7/15

Y1 - 2015/7/15

N2 - Myocarditis, i.e. inflammation of the myocardium, is one of the leading causes of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important cause of symptoms such as chest pain, dyspnea and palpitations. The pathophysiological process of disease progression leading to DCM involves an ongoing inflammation as a result of a viral-induced auto-immune response or a persisting viral infection. It is therefore crucial to detect the disease early in its course and prevent persisting inflammation that may lead to DCM and end-stage heart failure. Because of the highly variable clinical presentation, ranging from mild symptoms to severe heart failure, and the limited available diagnostic tools, the evaluation of patients with suspected myocarditis represents an important clinical dilemma in cardiology. New approaches for the diagnosis of myocarditis are needed in order to improve recognition, to help unravel its pathophysiology, and to develop new therapeutic strategies to treat the disease. In this review, we give a comprehensive overview of the current diagnostic strategies for patients with suspected myocarditis, and demonstrate several new techniques that may help to improve the diagnostic work-up.

AB - Myocarditis, i.e. inflammation of the myocardium, is one of the leading causes of sudden cardiac death (SCD) and dilated cardiomyopathy (DCM) in young adults, and is an important cause of symptoms such as chest pain, dyspnea and palpitations. The pathophysiological process of disease progression leading to DCM involves an ongoing inflammation as a result of a viral-induced auto-immune response or a persisting viral infection. It is therefore crucial to detect the disease early in its course and prevent persisting inflammation that may lead to DCM and end-stage heart failure. Because of the highly variable clinical presentation, ranging from mild symptoms to severe heart failure, and the limited available diagnostic tools, the evaluation of patients with suspected myocarditis represents an important clinical dilemma in cardiology. New approaches for the diagnosis of myocarditis are needed in order to improve recognition, to help unravel its pathophysiology, and to develop new therapeutic strategies to treat the disease. In this review, we give a comprehensive overview of the current diagnostic strategies for patients with suspected myocarditis, and demonstrate several new techniques that may help to improve the diagnostic work-up.

KW - Animals

KW - Biomarkers

KW - Cardiomyopathy, Dilated

KW - Endocardium

KW - Forecasting

KW - Humans

KW - Magnetic Resonance Imaging, Cine

KW - Myocarditis

KW - Journal Article

KW - Review

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M3 - Review article

VL - 191

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JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

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