Diagnostic Accuracy of Probe to Bone to Detect Osteomyelitis in the Diabetic Foot: A Systematic Review: Clinical Infectious Diseases

K. Lam, S. A. V. van Asten, Hang T. T. Nguyen, J La Fontaine, Lawrence A Lavery

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We aimed to identify the diagnostic accuracy of the probe-to-bone test to diagnose diabetic foot osteomyelitis through a meta-analysis of the published literature. Our findings support the use of probe to bone as outlined by current guidelines.The probe-to-bone (PTB) test is a commonly used clinical test for osteomyelitis (OM), but its utility has been questioned in clinical settings where the prevalence of OM is low. This article aims to systematically review the accuracy of the PTB test to diagnose diabetic foot OM. We searched Ovid Medline and Scopus databases for studies using the keywords "probe to bone," "osteomyelitis," and "diabetic foot" from 1946 to May 2015. We summarized characteristics of the included studies and pooled the accuracy numbers using a bivariate random-effects model. Seven studies met our inclusion criteria. Pooled sensitivity and specificity for the PTB test was 0.87 (95% confidence interval [CI], .75-.93) and 0.83 (95% CI, .65-.93), respectively. We conclude that the PTB test can accurately rule in diabetic foot OM in the high-risk patients and rule out OM in low-risk patients.
Original languageEnglish
Pages (from-to)944-948
Number of pages5
JournalClinical Infectious Diseases
Volume63
DOIs
Publication statusPublished - 2016

Cite this

Lam, K. ; van Asten, S. A. V. ; Nguyen, Hang T. T. ; La Fontaine, J ; Lavery, Lawrence A. / Diagnostic Accuracy of Probe to Bone to Detect Osteomyelitis in the Diabetic Foot: A Systematic Review : Clinical Infectious Diseases. In: Clinical Infectious Diseases. 2016 ; Vol. 63. pp. 944-948.
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abstract = "We aimed to identify the diagnostic accuracy of the probe-to-bone test to diagnose diabetic foot osteomyelitis through a meta-analysis of the published literature. Our findings support the use of probe to bone as outlined by current guidelines.The probe-to-bone (PTB) test is a commonly used clinical test for osteomyelitis (OM), but its utility has been questioned in clinical settings where the prevalence of OM is low. This article aims to systematically review the accuracy of the PTB test to diagnose diabetic foot OM. We searched Ovid Medline and Scopus databases for studies using the keywords {"}probe to bone,{"} {"}osteomyelitis,{"} and {"}diabetic foot{"} from 1946 to May 2015. We summarized characteristics of the included studies and pooled the accuracy numbers using a bivariate random-effects model. Seven studies met our inclusion criteria. Pooled sensitivity and specificity for the PTB test was 0.87 (95{\%} confidence interval [CI], .75-.93) and 0.83 (95{\%} CI, .65-.93), respectively. We conclude that the PTB test can accurately rule in diabetic foot OM in the high-risk patients and rule out OM in low-risk patients.",
author = "K. Lam and {van Asten}, {S. A. V.} and Nguyen, {Hang T. T.} and {La Fontaine}, J and Lavery, {Lawrence A}",
note = "M1 - 7 ISI Document Delivery No.: DZ7JL Times Cited: 1 Cited Reference Count: 35 Lam, Kenrick van Asten, Suzanne A. V. Tea Nguyen La Fontaine, Javier Lavery, Lawrence A. Osiris; MacroCure; Integra; GlaxoSmithKline; KCI; Cardinal L. A. L. has served as a consultant for Aplion Medical Users, Harbor MedTech, Podometrics, and HyperMed; has received grant funding from Osiris, MacroCure, Integra, GlaxoSmithKline, KCI, and Cardinal; and is a member of the speaker's bureaus for Osiris, Integra, and Smith & Nephew. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. 1 OXFORD UNIV PRESS INC CARY CLIN INFECT DIS",
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Diagnostic Accuracy of Probe to Bone to Detect Osteomyelitis in the Diabetic Foot: A Systematic Review : Clinical Infectious Diseases. / Lam, K.; van Asten, S. A. V.; Nguyen, Hang T. T.; La Fontaine, J; Lavery, Lawrence A.

In: Clinical Infectious Diseases, Vol. 63, 2016, p. 944-948.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Diagnostic Accuracy of Probe to Bone to Detect Osteomyelitis in the Diabetic Foot: A Systematic Review

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AU - Lam, K.

AU - van Asten, S. A. V.

AU - Nguyen, Hang T. T.

AU - La Fontaine, J

AU - Lavery, Lawrence A

N1 - M1 - 7 ISI Document Delivery No.: DZ7JL Times Cited: 1 Cited Reference Count: 35 Lam, Kenrick van Asten, Suzanne A. V. Tea Nguyen La Fontaine, Javier Lavery, Lawrence A. Osiris; MacroCure; Integra; GlaxoSmithKline; KCI; Cardinal L. A. L. has served as a consultant for Aplion Medical Users, Harbor MedTech, Podometrics, and HyperMed; has received grant funding from Osiris, MacroCure, Integra, GlaxoSmithKline, KCI, and Cardinal; and is a member of the speaker's bureaus for Osiris, Integra, and Smith & Nephew. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. 1 OXFORD UNIV PRESS INC CARY CLIN INFECT DIS

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N2 - We aimed to identify the diagnostic accuracy of the probe-to-bone test to diagnose diabetic foot osteomyelitis through a meta-analysis of the published literature. Our findings support the use of probe to bone as outlined by current guidelines.The probe-to-bone (PTB) test is a commonly used clinical test for osteomyelitis (OM), but its utility has been questioned in clinical settings where the prevalence of OM is low. This article aims to systematically review the accuracy of the PTB test to diagnose diabetic foot OM. We searched Ovid Medline and Scopus databases for studies using the keywords "probe to bone," "osteomyelitis," and "diabetic foot" from 1946 to May 2015. We summarized characteristics of the included studies and pooled the accuracy numbers using a bivariate random-effects model. Seven studies met our inclusion criteria. Pooled sensitivity and specificity for the PTB test was 0.87 (95% confidence interval [CI], .75-.93) and 0.83 (95% CI, .65-.93), respectively. We conclude that the PTB test can accurately rule in diabetic foot OM in the high-risk patients and rule out OM in low-risk patients.

AB - We aimed to identify the diagnostic accuracy of the probe-to-bone test to diagnose diabetic foot osteomyelitis through a meta-analysis of the published literature. Our findings support the use of probe to bone as outlined by current guidelines.The probe-to-bone (PTB) test is a commonly used clinical test for osteomyelitis (OM), but its utility has been questioned in clinical settings where the prevalence of OM is low. This article aims to systematically review the accuracy of the PTB test to diagnose diabetic foot OM. We searched Ovid Medline and Scopus databases for studies using the keywords "probe to bone," "osteomyelitis," and "diabetic foot" from 1946 to May 2015. We summarized characteristics of the included studies and pooled the accuracy numbers using a bivariate random-effects model. Seven studies met our inclusion criteria. Pooled sensitivity and specificity for the PTB test was 0.87 (95% confidence interval [CI], .75-.93) and 0.83 (95% CI, .65-.93), respectively. We conclude that the PTB test can accurately rule in diabetic foot OM in the high-risk patients and rule out OM in low-risk patients.

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M3 - Article

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SP - 944

EP - 948

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

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