Diagnostisch dilemma: trombotische microangiopathie tijdens de behandeling voor acute lymfatische leukemie

Translated title of the contribution: Diagnostic challenge: trombotic microangiopathy during the treatment of acute lymphatic leukemia

Research output: Contribution to journalArticleProfessional


A 38 year-old patient with T-cell acute lymphatic
leukemia (T-ALL) for which she was treated with
chemotherapy according to the HOVON 100A schedule,
presented with fever and edema of the eye lids.
During the hospitalization thrombotic micro-angiopathy
(TMA) developed, which was attributed to
either secondary TMA or atypical hemolytic uremic
syndrome (aHUS). Treatment with plasma therapy
was started, but because of insufficient clinical
improvement after five days of plasma therapy treatment
with the complement inhibitor eculizumab
was started, to which she responded well. This case
illustrates the complex differential diagnosis in
patients presenting with TMA and the complicated
considerations for selecting the appropriate treatment.
Original languageDutch
Pages (from-to)382-389
JournalNederlands Tijdschrift voor Hematologie
Issue number14
Publication statusPublished - 2017

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