Diagnostic challenge: trombotic microangiopathy during the treatment of acute lymphatic leukemia

Research output: Contribution to journalArticleProfessional

Abstract

A 38 year-old patient with T-cell acute lymphatic
leukemia (T-ALL) for which she was treated with
chemotherapy according to the HOVON 100A schedule,
presented with fever and edema of the eye lids.
During the hospitalization thrombotic micro-angiopathy
(TMA) developed, which was attributed to
either secondary TMA or atypical hemolytic uremic
syndrome (aHUS). Treatment with plasma therapy
was started, but because of insufficient clinical
improvement after five days of plasma therapy treatment
with the complement inhibitor eculizumab
was started, to which she responded well. This case
illustrates the complex differential diagnosis in
patients presenting with TMA and the complicated
considerations for selecting the appropriate treatment.
Translated title of the contributionDiagnostic challenge: trombotic microangiopathy during the treatment of acute lymphatic leukemia
Original languageDutch
Pages (from-to)382-389
JournalNederlands Tijdschrift voor Hematologie
Volume2017
Issue number14
Publication statusPublished - 2017

Cite this

@article{1fad23324ea845b8b7ef750c03f53e4c,
title = "Diagnostisch dilemma: trombotische microangiopathie tijdens de behandeling voor acute lymfatische leukemie",
abstract = "A 38 year-old patient with T-cell acute lymphaticleukemia (T-ALL) for which she was treated withchemotherapy according to the HOVON 100A schedule,presented with fever and edema of the eye lids.During the hospitalization thrombotic micro-angiopathy(TMA) developed, which was attributed toeither secondary TMA or atypical hemolytic uremicsyndrome (aHUS). Treatment with plasma therapywas started, but because of insufficient clinicalimprovement after five days of plasma therapy treatmentwith the complement inhibitor eculizumabwas started, to which she responded well. This caseillustrates the complex differential diagnosis inpatients presenting with TMA and the complicatedconsiderations for selecting the appropriate treatment.",
author = "LC Hamming and {van der Heijden}, JW and MJ Wondergem and MD Hazenberg and S Zweegman",
year = "2017",
language = "Dutch",
volume = "2017",
pages = "382--389",
journal = "Nederlands Tijdschrift voor Hematologie",
issn = "1572-1590",
number = "14",

}

TY - JOUR

T1 - Diagnostisch dilemma

T2 - trombotische microangiopathie tijdens de behandeling voor acute lymfatische leukemie

AU - Hamming, LC

AU - van der Heijden, JW

AU - Wondergem, MJ

AU - Hazenberg, MD

AU - Zweegman, S

PY - 2017

Y1 - 2017

N2 - A 38 year-old patient with T-cell acute lymphaticleukemia (T-ALL) for which she was treated withchemotherapy according to the HOVON 100A schedule,presented with fever and edema of the eye lids.During the hospitalization thrombotic micro-angiopathy(TMA) developed, which was attributed toeither secondary TMA or atypical hemolytic uremicsyndrome (aHUS). Treatment with plasma therapywas started, but because of insufficient clinicalimprovement after five days of plasma therapy treatmentwith the complement inhibitor eculizumabwas started, to which she responded well. This caseillustrates the complex differential diagnosis inpatients presenting with TMA and the complicatedconsiderations for selecting the appropriate treatment.

AB - A 38 year-old patient with T-cell acute lymphaticleukemia (T-ALL) for which she was treated withchemotherapy according to the HOVON 100A schedule,presented with fever and edema of the eye lids.During the hospitalization thrombotic micro-angiopathy(TMA) developed, which was attributed toeither secondary TMA or atypical hemolytic uremicsyndrome (aHUS). Treatment with plasma therapywas started, but because of insufficient clinicalimprovement after five days of plasma therapy treatmentwith the complement inhibitor eculizumabwas started, to which she responded well. This caseillustrates the complex differential diagnosis inpatients presenting with TMA and the complicatedconsiderations for selecting the appropriate treatment.

M3 - Article

VL - 2017

SP - 382

EP - 389

JO - Nederlands Tijdschrift voor Hematologie

JF - Nederlands Tijdschrift voor Hematologie

SN - 1572-1590

IS - 14

ER -