Diaphragm Muscle Trophicity: The Long and Short of Titin Mechanosensing

Robbert Jan van der Pijl

Research output: PhD ThesisPhd-Thesis - Research and graduation internal


The diaphragm is the primary muscle of ventilation. Pathology involving the diaphragm is severely detrimental for the quality of life. Gaining insight into the mechanisms underlying changes in diaphragm trophicity is vital for understanding muscle plasticity. One of these mechanisms involves titin mechanosensing, a mechanism that may be harnessed to counter adverse changes in diaphragm pathology. The aims of this dissertation were to gain insight into the relation of titin-mechanosensing and diaphragm trophicity, and how this relates to the pathomechanism of diaphragm weakness following mechanical ventilation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Vrije Universiteit Amsterdam
  • Ottenheijm, Coen, Supervisor
  • Granzier, Henk, Supervisor, External person
Award date5 Jul 2021
Print ISBNs9789464165968
Publication statusPublished - 6 Jul 2021

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