Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes

Joline W.J. Beulens, Daphne L. Van Der A, Diederick E. Grobbee, Ivonne Sluijs, Annemieke M.W. Spijkerman, Yvonne T. Van Der Schouw

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE- To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS- We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records. RESULTS- During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-μg increment in the multivariate model. CONCLUSIONS- This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.

Original languageEnglish
Pages (from-to)1699-1705
Number of pages7
JournalDiabetes Care
Volume33
Issue number8
DOIs
Publication statusPublished - 1 Aug 2010

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