Differences between hereditary and sporadic ovarian cancer

R P Zweemer, R H Verheijen, F H Menko, J J Gille, P J van Diest, J W Coebergh, P A Shaw, I J Jacobs, P Kenemans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.

Original languageEnglish
Pages (from-to)151-3
Number of pages3
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume82
Issue number2
Publication statusPublished - Feb 1999

Cite this

Zweemer, R. P., Verheijen, R. H., Menko, F. H., Gille, J. J., van Diest, P. J., Coebergh, J. W., ... Kenemans, P. (1999). Differences between hereditary and sporadic ovarian cancer. European Journal of Obstetrics and Gynecology and Reproductive Biology, 82(2), 151-3.
Zweemer, R P ; Verheijen, R H ; Menko, F H ; Gille, J J ; van Diest, P J ; Coebergh, J W ; Shaw, P A ; Jacobs, I J ; Kenemans, P. / Differences between hereditary and sporadic ovarian cancer. In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 1999 ; Vol. 82, No. 2. pp. 151-3.
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title = "Differences between hereditary and sporadic ovarian cancer",
abstract = "Approximately 5{\%} of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.",
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Zweemer, RP, Verheijen, RH, Menko, FH, Gille, JJ, van Diest, PJ, Coebergh, JW, Shaw, PA, Jacobs, IJ & Kenemans, P 1999, 'Differences between hereditary and sporadic ovarian cancer' European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 82, no. 2, pp. 151-3.

Differences between hereditary and sporadic ovarian cancer. / Zweemer, R P; Verheijen, R H; Menko, F H; Gille, J J; van Diest, P J; Coebergh, J W; Shaw, P A; Jacobs, I J; Kenemans, P.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 82, No. 2, 02.1999, p. 151-3.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Differences between hereditary and sporadic ovarian cancer

AU - Zweemer, R P

AU - Verheijen, R H

AU - Menko, F H

AU - Gille, J J

AU - van Diest, P J

AU - Coebergh, J W

AU - Shaw, P A

AU - Jacobs, I J

AU - Kenemans, P

PY - 1999/2

Y1 - 1999/2

N2 - Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.

AB - Approximately 5% of ovarian cancer cases can be attributed to an autosomal dominant inheritance factor. The majority of these cases are due to germline mutations in the BRCA1 or BRCA2 tumoursupressor genes. Patients with hereditary disease do not exhibit pathognomonic features that would allow distinction from non-hereditary (sporadic) cases of ovarian cancer. Our studies are aimed at identifying clinical, histopathological as well as molecular genetic differences between hereditary and sporadic ovarian cancer. Clinical studies of the ovarian cancer cases in 31 families revealed differences regarding age at onset and stage as well as in survival compared with cancer registry controls. The molecular studies of hereditary ovarian cancer are still underway and some preliminary data is discussed.

KW - Age Factors

KW - BRCA2 Protein

KW - Female

KW - Genes, BRCA1/genetics

KW - Genes, p53/genetics

KW - Humans

KW - Mutation

KW - Neoplasm Proteins/genetics

KW - Neoplasm Staging

KW - Ovarian Neoplasms/epidemiology

KW - Registries

KW - Survival Rate

KW - Transcription Factors/genetics

M3 - Article

VL - 82

SP - 151

EP - 153

JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

SN - 0301-2115

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Zweemer RP, Verheijen RH, Menko FH, Gille JJ, van Diest PJ, Coebergh JW et al. Differences between hereditary and sporadic ovarian cancer. European Journal of Obstetrics and Gynecology and Reproductive Biology. 1999 Feb;82(2):151-3.