Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease. Methods: A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed. Results: Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91%) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61%). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases. Conclusion: Metastatic ACC is not always an indolent disease.

Original languageEnglish
Pages (from-to)456-463
Number of pages8
JournalHead and Neck
Volume39
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Cite this

@article{92db55435d9e45dd97a9c54fd9940ca2,
title = "Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck",
abstract = "Background: We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease. Methods: A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed. Results: Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91{\%}) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61{\%}). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases. Conclusion: Metastatic ACC is not always an indolent disease.",
keywords = "adenoid cystic carcinoma, distant metastases, head and neck, patterns of survival, solid type histology",
author = "{van Weert}, Stijn and Rinze Reinhard and Elisabeth Bloemena and Jan Buter and Witte, {Birgit I.} and Vergeer, {Marije R.} and Leemans, {C. Ren{\'e}}",
year = "2017",
month = "3",
day = "1",
doi = "10.1002/hed.24613",
language = "English",
volume = "39",
pages = "456--463",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "Wiley Subscription Services, Inc., A Wiley Company Hoboken",
number = "3",

}

Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck. / van Weert, Stijn; Reinhard, Rinze; Bloemena, Elisabeth; Buter, Jan; Witte, Birgit I.; Vergeer, Marije R.; Leemans, C. René.

In: Head and Neck, Vol. 39, No. 3, 01.03.2017, p. 456-463.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck

AU - van Weert, Stijn

AU - Reinhard, Rinze

AU - Bloemena, Elisabeth

AU - Buter, Jan

AU - Witte, Birgit I.

AU - Vergeer, Marije R.

AU - Leemans, C. René

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease. Methods: A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed. Results: Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91%) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61%). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases. Conclusion: Metastatic ACC is not always an indolent disease.

AB - Background: We examined the assumption in conventional teaching about metastatic adenoid cystic carcinoma (ACC) being an indolent type of disease. Methods: A single center analysis of 105 cases of ACC was performed. Radiographs were reviewed and tumor response to chemotherapy was measured. Distant disease-free survival (DDFS) and time to death since distant metastases diagnosis were analyzed. Results: Forty-two percent of the patients were diagnosed with distant metastases. DDFS showed significant negative associations with advanced T classification, N+ classification, solid type tumor, and positive surgical margins. Distant metastases (91%) developed in the first 5 years after presentation. Median distant metastatic survival was 13.8 months. The most frequent organ sited was the lung. Solid type ACC showed a preponderance for multiorgan metastases (17/28; 61%). Distant metastases seemed not to occur in case of clear surgical margins. Solid type ACC had a significant poorer survival after development of distant metastases. Conclusion: Metastatic ACC is not always an indolent disease.

KW - adenoid cystic carcinoma

KW - distant metastases

KW - head and neck

KW - patterns of survival

KW - solid type histology

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