Different EEG frequency band synchronization during nocturnal frontal lobe seizures

Raffaele Ferri, Cornelis J Stam, Bartolo Lanuzza, Filomena I I Cosentino, Maurizio Elia, Sebastiano A Musumeci, Giovanni Pennisi

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: In this article we describe the course of synchronization between different EEG channels during nocturnal seizures in one patient with nocturnal frontal lobe epilepsy (NFLE).

METHODS: The functional interactions between the different EEG channels during the nocturnal seizures were analyzed by means of the so-called synchronization likelihood (SL). SL is a measure of the dynamical interdependencies between a time series (EEG channel) and one or more other time series. In contrast to coherence, SL measures linear as well as non-linear interdependencies and it can do so as a function of time, making it suitable for non-stationary time series.

RESULTS: The main result of our single-patient study is the demonstration of a significant hyper-synchronization during NFLE seizures in the 8-12 Hz band which seems to be stopped by an increase in synchronization in the 0.5-4 Hz band, towards the end of each ictal episode.

CONCLUSIONS: We suggest that a self-inhibiting complex mechanism might be responsible for the termination of ictal episodes which might take place at the level of the cortical layers and might involve mainly pyramidal neurons.

SIGNIFICANCE: This study shows that advanced EEG analysis methods can help the current understanding of ictal manifestations of NFLE.

Original languageEnglish
Pages (from-to)1202-11
Number of pages10
JournalClinical Neurophysiology
Volume115
Issue number5
DOIs
Publication statusPublished - May 2004

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