Differentiation Between Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease Based on Fecal Scent: Proof of Principle Study

Sofie Bosch, Nora van Gaal, Roy P. Zuurbier, James A. Covington, Alfian N. Wicaksono, Maarten H. Biezeveld, Marc A. Benninga, Chris J. Mulder, Nanne K. H. de Boer, Tim G. J. de Meij

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs). The object of the study was to evaluate whether pediatric IBS/FAP-NOS could be discriminated from IBD and healthy controls by fecal VOC analysis.
LanguageEnglish
Pages2468-2475
JournalInflammatory Bowel Diseases
Volume24
Issue number11
DOIs
Publication statusPublished - 2018

Cite this

Bosch, Sofie ; van Gaal, Nora ; Zuurbier, Roy P. ; Covington, James A. ; Wicaksono, Alfian N. ; Biezeveld, Maarten H. ; Benninga, Marc A. ; Mulder, Chris J. ; de Boer, Nanne K. H. ; de Meij, Tim G. J. / Differentiation Between Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease Based on Fecal Scent: Proof of Principle Study. In: Inflammatory Bowel Diseases. 2018 ; Vol. 24, No. 11. pp. 2468-2475.
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abstract = "Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs). The object of the study was to evaluate whether pediatric IBS/FAP-NOS could be discriminated from IBD and healthy controls by fecal VOC analysis.",
author = "Sofie Bosch and {van Gaal}, Nora and Zuurbier, {Roy P.} and Covington, {James A.} and Wicaksono, {Alfian N.} and Biezeveld, {Maarten H.} and Benninga, {Marc A.} and Mulder, {Chris J.} and {de Boer}, {Nanne K. H.} and {de Meij}, {Tim G. J.}",
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Differentiation Between Pediatric Irritable Bowel Syndrome and Inflammatory Bowel Disease Based on Fecal Scent: Proof of Principle Study. / Bosch, Sofie; van Gaal, Nora; Zuurbier, Roy P.; Covington, James A.; Wicaksono, Alfian N.; Biezeveld, Maarten H.; Benninga, Marc A.; Mulder, Chris J.; de Boer, Nanne K. H.; de Meij, Tim G. J.

In: Inflammatory Bowel Diseases, Vol. 24, No. 11, 2018, p. 2468-2475.

Research output: Contribution to journalArticleAcademicpeer-review

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