Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

Elisabeth Bergers*, Joost C.J. Bot, Paul van der Valk, Jonas A. Castelijns, Geert J.Lycklama A. Nijeholt, Wouter Kamphorst, Chris H. Polman, Erwin L.A. Blezer, Klaas Nicolay, Rivka Ravid, Frederik Barkhof

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.

Original languageEnglish
Pages (from-to)652-656
Number of pages5
JournalAnnals of Neurology
Issue number5
Publication statusPublished - 6 May 2002

Cite this