Diffusiegewogen MRI bij neonatale Bacillus cereus meningo-encefalitis

Translated title of the contribution: Diffusion weighted MRI of neonates with meningoencephalitis caused by Bacillus cereus

R. J. Vermeulen*, R. M. Van Elburg, W. C. Van Der Zwet, A. M. Van Furth, J. I.M.L. Verbeke, F. Barkhof, M. S. Van Der Knaap

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


T1 and T2 weighted MR images of the brain are very suitable to demonstrate the integrity of the infant's brain. Diffusion weighted MRI is a new promising technique which is sensitive to conditions with restricted water diffusion, e.g. cytotoxic edema in infection and ischaemia. The value of this new MRI technique will be discussed in relation to two patients with severe neurological problems. Two premature infants developed a Bacillus cereus infection of the central nervous system. T1 weighted MR1 showed a hyperintense signal in the entire cerebral cortex and white matter; some of these areas were hypointense on T2 weighted MR1, suggestive of hemorrhage. On T2 weighted MRI part of the cortex was abnormal whereas the basal nuclei appeared normal. DW1 showed increased signal in basal nuclei and cortex, probably due to cytotoxic edema. Conclusion: Bacillus cereus infection of the central nervous system can lead to a severe hemorrhagic meningo-encephalitis. MR1 is an excellent technique to investigate the extent of lesions in the brain. Diffusion weighted MR1 has an additional value in detecting extra lesions most probably due to cytotoxic edema.

Original languageDutch
Pages (from-to)45-49
Number of pages5
JournalTijdschrift voor Kindergeneeskunde
Issue number2
Publication statusPublished - 1 Apr 2003

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