TY - JOUR
T1 - Diphtheria tetanus pertussis poliomyelitis vaccination and reported atopic disorders in 8-12-year-old children
AU - Bernsen, Roos M D
AU - de Jongste, Johan C
AU - Koes, Bart W
AU - Aardoom, Harry A
AU - van der Wouden, Johannes C
PY - 2006/3/15
Y1 - 2006/3/15
N2 - BACKGROUND: Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and atopic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication.STUDY OBJECTIVE: To assess the relationship between diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination (DTP-IPV) in the first year of life and reported atopic disorders at primary school age.METHOD: 1875 children attending Orthodox Reformed (Protestant) primary schools in the Netherlands returned questionnaires with data on vaccination status, atopic symptoms and lifetime atopic disorders (asthma, hay fever, eczema and food allergy), and possible confounders.RESULTS: The adjusted odds ratio of any atopic disorder (vaccinated/unvaccinated) was 1.00 (CI95%: 0.80-1.24). For asthma, hay fever, eczema and food allergy the results were respectively: 1.04 (CI95%: 0.76-1.42), 0.79 (CI95%: 0.55-1.12), 0.87 (CI95%: 0.66-1.14) and 1.13 (CI95%: 0.71-1.81).CONCLUSION: The DTP-IPV vaccination was not related to reported atopic disorders at primary school age.
AB - BACKGROUND: Evidence for the relationship between the diphtheria tetanus pertussis (DTP) vaccination and atopic disorders is inconclusive, because the available studies that constitute the evidence are liable to confounding by indication.STUDY OBJECTIVE: To assess the relationship between diphtheria-tetanus-pertussis-(inactivated) poliomyelitis vaccination (DTP-IPV) in the first year of life and reported atopic disorders at primary school age.METHOD: 1875 children attending Orthodox Reformed (Protestant) primary schools in the Netherlands returned questionnaires with data on vaccination status, atopic symptoms and lifetime atopic disorders (asthma, hay fever, eczema and food allergy), and possible confounders.RESULTS: The adjusted odds ratio of any atopic disorder (vaccinated/unvaccinated) was 1.00 (CI95%: 0.80-1.24). For asthma, hay fever, eczema and food allergy the results were respectively: 1.04 (CI95%: 0.76-1.42), 0.79 (CI95%: 0.55-1.12), 0.87 (CI95%: 0.66-1.14) and 1.13 (CI95%: 0.71-1.81).CONCLUSION: The DTP-IPV vaccination was not related to reported atopic disorders at primary school age.
KW - Child
KW - Cross-Sectional Studies
KW - Diphtheria-Tetanus-Pertussis Vaccine/administration & dosage
KW - Humans
KW - Hypersensitivity, Immediate/epidemiology
KW - Poliovirus Vaccine, Inactivated/administration & dosage
KW - Risk Factors
KW - Vaccination/adverse effects
KW - Vaccines, Combined/adverse effects
U2 - 10.1016/j.vaccine.2005.10.056
DO - 10.1016/j.vaccine.2005.10.056
M3 - Article
C2 - 16368169
SN - 0264-410X
VL - 24
SP - 2035
EP - 2042
JO - Vaccine
JF - Vaccine
IS - 12
ER -