Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: Rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic

Gideon B. Valstar, Sophie H. Bots, Floor Groepenhoff, Aisha Gohar, Frans H. Rutten, Tim Leiner, Maarten Jan Maria Cramer, Arco J. Teske, Leonardo P. Suciadi, Roxana Menken, Gerard Pasterkamp, Folkert W. Asselbergs, Leonard Hofstra, Michael L. Bots, Hester M. den Ruijter

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often in women than in men. Both LVDD and HFpEF often go unrecognised, necessitating the discovery of biomarkers that aid both the identification of individuals with LVDD at risk of developing HF and identification of individuals most likely to benefit from treatment. Methods and analysis HELPFul is an ongoing case-cohort study at a Dutch cardiology outpatient clinic enrolling patients aged 45 years and older without history of cardiovascular disease, who were referred by the general practitioner for cardiac evaluation. We included a random sample of patients and enriched the cohort with cases (defined as an E/e' ≥8 measured with echocardiography). Information about medical history, cardiovascular risk factors, electrocardiography, echocardiography, exercise test performance, common carotid intima-media thickness measurement and standard cardiovascular biomarkers was obtained from the routine care data collected by the cardiology outpatient clinic. Study procedure consists of extensive venous blood collection for biobanking and additional standardised questionnaires. Follow-up will consist of standardised questionnaires by mail and linkage to regional and national registries. We will perform cardiac magnetic resonance imaging and coronary CT angiography in a subgroup of patients to investigate the extent of macrovascular and microvascular coronary disease. Ethics and dissemination The study protocol was approved by the Institutional Review Board of the University Medical Center Utrecht. Results will be disseminated through national and international conferences and in peer-reviewed journals in cardiovascular disease. Trial registration NTR6016;Pre-results.
Original languageEnglish
Article numbere028408
JournalBMJ Open
Volume9
Issue number6
DOIs
Publication statusPublished - 2019

Cite this

Valstar, Gideon B. ; Bots, Sophie H. ; Groepenhoff, Floor ; Gohar, Aisha ; Rutten, Frans H. ; Leiner, Tim ; Cramer, Maarten Jan Maria ; Teske, Arco J. ; Suciadi, Leonardo P. ; Menken, Roxana ; Pasterkamp, Gerard ; Asselbergs, Folkert W. ; Hofstra, Leonard ; Bots, Michael L. ; den Ruijter, Hester M. / Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: Rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic. In: BMJ Open. 2019 ; Vol. 9, No. 6.
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title = "Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: Rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic",
abstract = "Introduction Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often in women than in men. Both LVDD and HFpEF often go unrecognised, necessitating the discovery of biomarkers that aid both the identification of individuals with LVDD at risk of developing HF and identification of individuals most likely to benefit from treatment. Methods and analysis HELPFul is an ongoing case-cohort study at a Dutch cardiology outpatient clinic enrolling patients aged 45 years and older without history of cardiovascular disease, who were referred by the general practitioner for cardiac evaluation. We included a random sample of patients and enriched the cohort with cases (defined as an E/e' ≥8 measured with echocardiography). Information about medical history, cardiovascular risk factors, electrocardiography, echocardiography, exercise test performance, common carotid intima-media thickness measurement and standard cardiovascular biomarkers was obtained from the routine care data collected by the cardiology outpatient clinic. Study procedure consists of extensive venous blood collection for biobanking and additional standardised questionnaires. Follow-up will consist of standardised questionnaires by mail and linkage to regional and national registries. We will perform cardiac magnetic resonance imaging and coronary CT angiography in a subgroup of patients to investigate the extent of macrovascular and microvascular coronary disease. Ethics and dissemination The study protocol was approved by the Institutional Review Board of the University Medical Center Utrecht. Results will be disseminated through national and international conferences and in peer-reviewed journals in cardiovascular disease. Trial registration NTR6016;Pre-results.",
author = "Valstar, {Gideon B.} and Bots, {Sophie H.} and Floor Groepenhoff and Aisha Gohar and Rutten, {Frans H.} and Tim Leiner and Cramer, {Maarten Jan Maria} and Teske, {Arco J.} and Suciadi, {Leonardo P.} and Roxana Menken and Gerard Pasterkamp and Asselbergs, {Folkert W.} and Leonard Hofstra and Bots, {Michael L.} and {den Ruijter}, {Hester M.}",
year = "2019",
doi = "10.1136/bmjopen-2018-028408",
language = "English",
volume = "9",
journal = "BMJ Open",
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Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: Rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic. / Valstar, Gideon B.; Bots, Sophie H.; Groepenhoff, Floor; Gohar, Aisha; Rutten, Frans H.; Leiner, Tim; Cramer, Maarten Jan Maria; Teske, Arco J.; Suciadi, Leonardo P.; Menken, Roxana; Pasterkamp, Gerard; Asselbergs, Folkert W.; Hofstra, Leonard; Bots, Michael L.; den Ruijter, Hester M.

In: BMJ Open, Vol. 9, No. 6, e028408, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: Rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic

AU - Valstar, Gideon B.

AU - Bots, Sophie H.

AU - Groepenhoff, Floor

AU - Gohar, Aisha

AU - Rutten, Frans H.

AU - Leiner, Tim

AU - Cramer, Maarten Jan Maria

AU - Teske, Arco J.

AU - Suciadi, Leonardo P.

AU - Menken, Roxana

AU - Pasterkamp, Gerard

AU - Asselbergs, Folkert W.

AU - Hofstra, Leonard

AU - Bots, Michael L.

AU - den Ruijter, Hester M.

PY - 2019

Y1 - 2019

N2 - Introduction Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often in women than in men. Both LVDD and HFpEF often go unrecognised, necessitating the discovery of biomarkers that aid both the identification of individuals with LVDD at risk of developing HF and identification of individuals most likely to benefit from treatment. Methods and analysis HELPFul is an ongoing case-cohort study at a Dutch cardiology outpatient clinic enrolling patients aged 45 years and older without history of cardiovascular disease, who were referred by the general practitioner for cardiac evaluation. We included a random sample of patients and enriched the cohort with cases (defined as an E/e' ≥8 measured with echocardiography). Information about medical history, cardiovascular risk factors, electrocardiography, echocardiography, exercise test performance, common carotid intima-media thickness measurement and standard cardiovascular biomarkers was obtained from the routine care data collected by the cardiology outpatient clinic. Study procedure consists of extensive venous blood collection for biobanking and additional standardised questionnaires. Follow-up will consist of standardised questionnaires by mail and linkage to regional and national registries. We will perform cardiac magnetic resonance imaging and coronary CT angiography in a subgroup of patients to investigate the extent of macrovascular and microvascular coronary disease. Ethics and dissemination The study protocol was approved by the Institutional Review Board of the University Medical Center Utrecht. Results will be disseminated through national and international conferences and in peer-reviewed journals in cardiovascular disease. Trial registration NTR6016;Pre-results.

AB - Introduction Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often in women than in men. Both LVDD and HFpEF often go unrecognised, necessitating the discovery of biomarkers that aid both the identification of individuals with LVDD at risk of developing HF and identification of individuals most likely to benefit from treatment. Methods and analysis HELPFul is an ongoing case-cohort study at a Dutch cardiology outpatient clinic enrolling patients aged 45 years and older without history of cardiovascular disease, who were referred by the general practitioner for cardiac evaluation. We included a random sample of patients and enriched the cohort with cases (defined as an E/e' ≥8 measured with echocardiography). Information about medical history, cardiovascular risk factors, electrocardiography, echocardiography, exercise test performance, common carotid intima-media thickness measurement and standard cardiovascular biomarkers was obtained from the routine care data collected by the cardiology outpatient clinic. Study procedure consists of extensive venous blood collection for biobanking and additional standardised questionnaires. Follow-up will consist of standardised questionnaires by mail and linkage to regional and national registries. We will perform cardiac magnetic resonance imaging and coronary CT angiography in a subgroup of patients to investigate the extent of macrovascular and microvascular coronary disease. Ethics and dissemination The study protocol was approved by the Institutional Review Board of the University Medical Center Utrecht. Results will be disseminated through national and international conferences and in peer-reviewed journals in cardiovascular disease. Trial registration NTR6016;Pre-results.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/31171553

U2 - 10.1136/bmjopen-2018-028408

DO - 10.1136/bmjopen-2018-028408

M3 - Article

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 6

M1 - e028408

ER -