Dissociable effects of cocaine and yohimbine on impulsive action and relapse to cocaine seeking

Nienke Broos, Yvar van Mourik, Dustin Schetters, Taco J De Vries, Tommy Pattij

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

RATIONALE: A strong association has been demonstrated between various forms of impulsivity and addiction-like behavior in both humans and rats.

OBJECTIVES: In this study, we investigated how impulsive action, as measured in the 5-choice serial reaction time task (5-CSRTT), is affected during various stages of cocaine taking and seeking and by relapse-provoking stimuli in animals that were trained both in an intravenous cocaine self-administration paradigm and in the 5-CSRTT.

METHODS: Rats were concurrently trained in the 5-CSRTT and cocaine self-administration protocol, and subsequently, the effects of cocaine (7.5 mg/kg) and the pharmacological stressor yohimbine (1.25 mg/kg) were tested in both paradigms.

RESULTS: Cocaine self-administration (5 h/day) transiently altered impulsive action and increased errors of omission in the 5-CSRTT. Pharmacological challenges with cocaine and yohimbine induced increments in impulsive action and reinstated cocaine-seeking responses within the same animals. Further analyses revealed that the effects of cocaine and yohimbine on impulsive action did not correlate with their effects on reinstatement of cocaine seeking.

CONCLUSIONS: These data suggest that although impulsive action and relapse can be pharmacologically modulated in the same direction within individuals, these effects appear not to be directly coupled.

Original languageEnglish
Pages (from-to)3343-3351
Number of pages9
JournalPsychopharmacology
Volume234
Issue number22
DOIs
Publication statusPublished - Nov 2017

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