Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking

Gabrielle D. Gibson, Asheeta A. Prasad, Philip Jean-Richard-dit-Bressel, Joanna O.Y. Yau, E. Zayra Millan, Yu Liu, Erin J. Campbell, Jun Lim, Nathan J. Marchant, John M. Power, Simon Killcross, Andrew J. Lawrence, Gavan P. McNally*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of context. However, the specific cell types, and projections, by which AcbSh serves these dual roles are unknown. Here, we show that contextual control over relapse and abstinence is embedded within distinct output circuits of dopamine 1 receptor (Drd1) expressing AcbSh neurons. We report anatomical and functional segregation of Drd1 AcbSh output pathways during context-induced reinstatement and extinction of alcohol seeking. The AcbSh→ventral tegmental area (VTA) pathway promotes relapse via projections to VTA Gad1 neurons. The AcbSh→lateral hypothalamus (LH) pathway promotes extinction via projections to LH Gad1 neurons. Targeting these opposing AcbSh circuit contributions may reduce propensity to relapse to, and promote abstinence from, drug use. Dopamine 1 receptor expressing neurons projecting from the accumbens shell to lateral hypothalamus and ventral tegmental area promote extinction versus reinstatement of reward seeking, respectively.

Original languageEnglish
Pages (from-to)512-520.e6
JournalNeuron
Volume98
Issue number3
DOIs
Publication statusPublished - 2 May 2018

Cite this

Gibson, G. D., Prasad, A. A., Jean-Richard-dit-Bressel, P., Yau, J. O. Y., Millan, E. Z., Liu, Y., ... McNally, G. P. (2018). Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking. Neuron, 98(3), 512-520.e6. https://doi.org/10.1016/j.neuron.2018.03.033