Pluriforme expressie van multipele endocriene neoplasie type I

Translated title of the contribution: Diversity in clinical outcome of multiple endocrine neoplasia type I

K. M.A. Dreijerink, J. F.M. Roijers, J. M. Jansen-Schillhorn van Veen, J. P. Neijt, Th J.M.V. Van Vroonhoven, C. J.M. Lips

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

MEN-I is an autosomal dominantly inherited disorder, characterised by the occurrence of multiple tumours, particularly in the parathyroid glands, the pancreatic islets, the pituitary gland and the adrenal glands, as well as by neuroendocrine carcinoid tumours. Various clinical manifestations are presented by description of three patients harbouring a MENI gene germline mutation. A 44-year-old man had symptoms of hyperparathyroidism and in addition to parathyroid adenomas proved to have tumours in the thymus, adrenal and pituitary glands. A 48-year-old woman from a family with MEN-I had suffered since her 40th year from headache and heartburn; she appeared to have adenomas in the parathyroid glands and gastrinomas in the pancreas, leading to a Zollinger-Ellison syndrome. One of her relatives, a man aged 29, had suffered from childhood from convulsions due to attacks of hypoglycaemia, and an insulinoma was assessed. In all patients, surgical and/or medical treatment alleviated symptoms. Clearly, the position or nature of the mutations in the MENI gene do not correlate with the clinical expression of the disease. Family investigation, DNA analysis and periodic examination improve quality of life and the life expectancy.

Original languageDutch
Pages (from-to)2437-2442
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Volume144
Issue number51
Publication statusPublished - 16 Dec 2000

Cite this

Dreijerink, K. M. A., Roijers, J. F. M., Jansen-Schillhorn van Veen, J. M., Neijt, J. P., Van Vroonhoven, T. J. M. V., & Lips, C. J. M. (2000). Pluriforme expressie van multipele endocriene neoplasie type I. Nederlands Tijdschrift voor Geneeskunde, 144(51), 2437-2442.