Do sex differences in CEOAEs and 2D: 4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked otoacoustic emissions show sex differences that are thought to reflect differences in early androgen exposure. Women with complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of XY-chromosomes, enabled us to study the effect of complete androgen inaction. The main goal was to investigate a possible link between click-evoked otoacoustic emissions and effective androgen exposure and, thus, whether this can be used as a biomarker. In addition, we aimed to replicate the only previous 2nd vs 4th digit-ratio study in women with CAIS, because despite the widely expressed criticisms of the validity of this measure as a biomarker for prenatal androgen exposure, it still is used for this purpose. Methods: Click-evoked otoacoustic emissions and digit ratios from women with CAIS were compared to those from control men and women. Results: The typical sex differences in click-evoked otoacoustic emissions and digit ratios were replicated in the control groups. Women with CAIS showed a tendency towards feminine, i.e., larger, click-evoked otoacoustic emission amplitudes in the right ear, and a significant female-typical, i.e., larger, digit ratio in the right hand. Although these results are consistent with androgen-dependent development of male-typical click-evoked otoacoustic emission amplitude and 2nd to 4th digit ratios, the within-group variability of these two measures was not reduced in women with CAIS compared with control women. Conclusions: In line with previous studies, our findings in CAIS women suggest that additional, non-androgenic, factors mediate male-typical sexual differentiation of digit ratios and click-evoked otoacoustic emissions. Consequently, use of these measures in adults as retrospective markers of early androgen exposure is not recommended.

Original languageEnglish
Article number11
JournalBiology of Sex Differences
Volume8
Issue number1
DOIs
Publication statusPublished - 12 Apr 2017

Cite this

@article{c73e5dc64e9c48dbbf7c929bdecce6fd,
title = "Do sex differences in CEOAEs and 2D: 4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome",
abstract = "Background: Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked otoacoustic emissions show sex differences that are thought to reflect differences in early androgen exposure. Women with complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of XY-chromosomes, enabled us to study the effect of complete androgen inaction. The main goal was to investigate a possible link between click-evoked otoacoustic emissions and effective androgen exposure and, thus, whether this can be used as a biomarker. In addition, we aimed to replicate the only previous 2nd vs 4th digit-ratio study in women with CAIS, because despite the widely expressed criticisms of the validity of this measure as a biomarker for prenatal androgen exposure, it still is used for this purpose. Methods: Click-evoked otoacoustic emissions and digit ratios from women with CAIS were compared to those from control men and women. Results: The typical sex differences in click-evoked otoacoustic emissions and digit ratios were replicated in the control groups. Women with CAIS showed a tendency towards feminine, i.e., larger, click-evoked otoacoustic emission amplitudes in the right ear, and a significant female-typical, i.e., larger, digit ratio in the right hand. Although these results are consistent with androgen-dependent development of male-typical click-evoked otoacoustic emission amplitude and 2nd to 4th digit ratios, the within-group variability of these two measures was not reduced in women with CAIS compared with control women. Conclusions: In line with previous studies, our findings in CAIS women suggest that additional, non-androgenic, factors mediate male-typical sexual differentiation of digit ratios and click-evoked otoacoustic emissions. Consequently, use of these measures in adults as retrospective markers of early androgen exposure is not recommended.",
keywords = "2D:4D, Androgens, CAIS, Complete androgen insensitivity syndrome, Digit ratios, Otoacoustic emissions, Sex chromosomes, Sex hormones, Sexual differentiation, Testosterone",
author = "{Van Hemmen}, Judy and Cohen-Kettenis, {Peggy T.} and Steensma, {Thomas D.} and Veltman, {Dick J.} and Julie Bakker",
year = "2017",
month = "4",
day = "12",
doi = "10.1186/s13293-017-0132-z",
language = "English",
volume = "8",
journal = "Biology of Sex Differences",
issn = "2042-6410",
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Do sex differences in CEOAEs and 2D : 4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome. / Van Hemmen, Judy; Cohen-Kettenis, Peggy T.; Steensma, Thomas D.; Veltman, Dick J.; Bakker, Julie.

In: Biology of Sex Differences, Vol. 8, No. 1, 11, 12.04.2017.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Do sex differences in CEOAEs and 2D

T2 - 4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome

AU - Van Hemmen, Judy

AU - Cohen-Kettenis, Peggy T.

AU - Steensma, Thomas D.

AU - Veltman, Dick J.

AU - Bakker, Julie

PY - 2017/4/12

Y1 - 2017/4/12

N2 - Background: Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked otoacoustic emissions show sex differences that are thought to reflect differences in early androgen exposure. Women with complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of XY-chromosomes, enabled us to study the effect of complete androgen inaction. The main goal was to investigate a possible link between click-evoked otoacoustic emissions and effective androgen exposure and, thus, whether this can be used as a biomarker. In addition, we aimed to replicate the only previous 2nd vs 4th digit-ratio study in women with CAIS, because despite the widely expressed criticisms of the validity of this measure as a biomarker for prenatal androgen exposure, it still is used for this purpose. Methods: Click-evoked otoacoustic emissions and digit ratios from women with CAIS were compared to those from control men and women. Results: The typical sex differences in click-evoked otoacoustic emissions and digit ratios were replicated in the control groups. Women with CAIS showed a tendency towards feminine, i.e., larger, click-evoked otoacoustic emission amplitudes in the right ear, and a significant female-typical, i.e., larger, digit ratio in the right hand. Although these results are consistent with androgen-dependent development of male-typical click-evoked otoacoustic emission amplitude and 2nd to 4th digit ratios, the within-group variability of these two measures was not reduced in women with CAIS compared with control women. Conclusions: In line with previous studies, our findings in CAIS women suggest that additional, non-androgenic, factors mediate male-typical sexual differentiation of digit ratios and click-evoked otoacoustic emissions. Consequently, use of these measures in adults as retrospective markers of early androgen exposure is not recommended.

AB - Background: Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked otoacoustic emissions show sex differences that are thought to reflect differences in early androgen exposure. Women with complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of XY-chromosomes, enabled us to study the effect of complete androgen inaction. The main goal was to investigate a possible link between click-evoked otoacoustic emissions and effective androgen exposure and, thus, whether this can be used as a biomarker. In addition, we aimed to replicate the only previous 2nd vs 4th digit-ratio study in women with CAIS, because despite the widely expressed criticisms of the validity of this measure as a biomarker for prenatal androgen exposure, it still is used for this purpose. Methods: Click-evoked otoacoustic emissions and digit ratios from women with CAIS were compared to those from control men and women. Results: The typical sex differences in click-evoked otoacoustic emissions and digit ratios were replicated in the control groups. Women with CAIS showed a tendency towards feminine, i.e., larger, click-evoked otoacoustic emission amplitudes in the right ear, and a significant female-typical, i.e., larger, digit ratio in the right hand. Although these results are consistent with androgen-dependent development of male-typical click-evoked otoacoustic emission amplitude and 2nd to 4th digit ratios, the within-group variability of these two measures was not reduced in women with CAIS compared with control women. Conclusions: In line with previous studies, our findings in CAIS women suggest that additional, non-androgenic, factors mediate male-typical sexual differentiation of digit ratios and click-evoked otoacoustic emissions. Consequently, use of these measures in adults as retrospective markers of early androgen exposure is not recommended.

KW - 2D:4D

KW - Androgens

KW - CAIS

KW - Complete androgen insensitivity syndrome

KW - Digit ratios

KW - Otoacoustic emissions

KW - Sex chromosomes

KW - Sex hormones

KW - Sexual differentiation

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85018492470&partnerID=8YFLogxK

U2 - 10.1186/s13293-017-0132-z

DO - 10.1186/s13293-017-0132-z

M3 - Article

VL - 8

JO - Biology of Sex Differences

JF - Biology of Sex Differences

SN - 2042-6410

IS - 1

M1 - 11

ER -