Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD?

A. Marije Boonstra, J. J. Sandra Kooij, Jaap Oosterlaan, Joseph A. Sergeant, Jan K. Buitelaar

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

We examined the effect of methylphenidate (Mph) on inhibition and several other cognitive abilities in 43 adults with Attention Deficit Hyperactivity Disorder (ADHD) by use of Conners' Continuous Performance Test (CPT) and the Change Task (ChT), an extension of the Stop Signal Test (SST). In a double blind, cross-over, placebo controlled study with Mph, tests were administered during the third week of individuall titrated treatment with Mph (maximum dose 1 mg/kg/day) and during the third week of treatment with placebo. We established large medication effects for commission errors, standard error of mean reaction time, and attentiveness on the CPT, as well as moderate medication effects for mean reaction time on the CPT and response re-engagement speed on the ChT. For Stop Signal Reaction Time (SSRT) on the ChT, we also established large effects of Mph, but only in a group of participants who showed slow SSRTs on placebo. Mph indeed ameliorates inhibition, which is the core problem of ADHD, and certain other cognitive abilities in adults with ADHD.
Original languageEnglish
Pages (from-to)278-298
JournalJournal of Clinical and Experimental Neuropsychology
Volume27
Issue number3
DOIs
Publication statusPublished - 2005
Externally publishedYes

Cite this

@article{27bf21d785554881b0330080ba5aeb45,
title = "Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD?",
abstract = "We examined the effect of methylphenidate (Mph) on inhibition and several other cognitive abilities in 43 adults with Attention Deficit Hyperactivity Disorder (ADHD) by use of Conners' Continuous Performance Test (CPT) and the Change Task (ChT), an extension of the Stop Signal Test (SST). In a double blind, cross-over, placebo controlled study with Mph, tests were administered during the third week of individuall titrated treatment with Mph (maximum dose 1 mg/kg/day) and during the third week of treatment with placebo. We established large medication effects for commission errors, standard error of mean reaction time, and attentiveness on the CPT, as well as moderate medication effects for mean reaction time on the CPT and response re-engagement speed on the ChT. For Stop Signal Reaction Time (SSRT) on the ChT, we also established large effects of Mph, but only in a group of participants who showed slow SSRTs on placebo. Mph indeed ameliorates inhibition, which is the core problem of ADHD, and certain other cognitive abilities in adults with ADHD.",
author = "Boonstra, {A. Marije} and Kooij, {J. J. Sandra} and Jaap Oosterlaan and Sergeant, {Joseph A.} and Buitelaar, {Jan K.}",
year = "2005",
doi = "10.1080/13803390490515757",
language = "English",
volume = "27",
pages = "278--298",
journal = "Journal of Clinical and Experimental Neuropsychology",
issn = "1380-3395",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD? / Boonstra, A. Marije; Kooij, J. J. Sandra; Oosterlaan, Jaap; Sergeant, Joseph A.; Buitelaar, Jan K.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 27, No. 3, 2005, p. 278-298.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD?

AU - Boonstra, A. Marije

AU - Kooij, J. J. Sandra

AU - Oosterlaan, Jaap

AU - Sergeant, Joseph A.

AU - Buitelaar, Jan K.

PY - 2005

Y1 - 2005

N2 - We examined the effect of methylphenidate (Mph) on inhibition and several other cognitive abilities in 43 adults with Attention Deficit Hyperactivity Disorder (ADHD) by use of Conners' Continuous Performance Test (CPT) and the Change Task (ChT), an extension of the Stop Signal Test (SST). In a double blind, cross-over, placebo controlled study with Mph, tests were administered during the third week of individuall titrated treatment with Mph (maximum dose 1 mg/kg/day) and during the third week of treatment with placebo. We established large medication effects for commission errors, standard error of mean reaction time, and attentiveness on the CPT, as well as moderate medication effects for mean reaction time on the CPT and response re-engagement speed on the ChT. For Stop Signal Reaction Time (SSRT) on the ChT, we also established large effects of Mph, but only in a group of participants who showed slow SSRTs on placebo. Mph indeed ameliorates inhibition, which is the core problem of ADHD, and certain other cognitive abilities in adults with ADHD.

AB - We examined the effect of methylphenidate (Mph) on inhibition and several other cognitive abilities in 43 adults with Attention Deficit Hyperactivity Disorder (ADHD) by use of Conners' Continuous Performance Test (CPT) and the Change Task (ChT), an extension of the Stop Signal Test (SST). In a double blind, cross-over, placebo controlled study with Mph, tests were administered during the third week of individuall titrated treatment with Mph (maximum dose 1 mg/kg/day) and during the third week of treatment with placebo. We established large medication effects for commission errors, standard error of mean reaction time, and attentiveness on the CPT, as well as moderate medication effects for mean reaction time on the CPT and response re-engagement speed on the ChT. For Stop Signal Reaction Time (SSRT) on the ChT, we also established large effects of Mph, but only in a group of participants who showed slow SSRTs on placebo. Mph indeed ameliorates inhibition, which is the core problem of ADHD, and certain other cognitive abilities in adults with ADHD.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=17144427289&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/15969353

U2 - 10.1080/13803390490515757

DO - 10.1080/13803390490515757

M3 - Article

VL - 27

SP - 278

EP - 298

JO - Journal of Clinical and Experimental Neuropsychology

JF - Journal of Clinical and Experimental Neuropsychology

SN - 1380-3395

IS - 3

ER -