Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis

S.M. van der Kooij, Y.P. Goekoop-Ruiterman, J.K. Bouwstra, M. Guler-Yuksel, A.H. Zwinderman, P.J.S.M. Kerstens, P.A.H.M. van der Lubbe, W.M. de Beus, B.A.M. Grillet, H.K. Ronday, T.W. Huizinga, F.C. Breedveld, B.A.C. Dijkmans, C.F. Allaart

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Abstract

Objectives: To compare the occurrence of drug-free remission, functional ability and radiological damage after 4 years of response-driven treatment according to four different treatment strategies for rheumatoid arthritis (RA). Methods: Patients with recent-onset, active RA (n = 508) were randomly assigned to four different treatment strategies: (1) sequential monotherapy; (2) step-up combination therapy; (3) initial combination therapy with prednisone and (4) initial combination therapy with infliximab. Treatment was adjusted based on 3-monthly disease activity score (DAS) assessments, aiming at a DAS (2.4. From the third year, patients with a sustained DAS,
Original languageEnglish
Pages (from-to)914-921
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume68
Issue number6
DOIs
Publication statusPublished - 2009

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