Drug transport to the brain: in vitro versus in vivo approaches

A. G. de Boer; H. E. de Vries; E. C.M. de Lange; M. Danhof; J. Kuiper; D. D. Breimer

doi:10.1016/0168-3659(94)90173-2

Drug transport to the brain: in vitro versus in vivo approaches

A. G. de Boer^*, H. E. de Vries, E. C.M. de Lange, M. Danhof, J. Kuiper, D. D. Breimer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This paper summarizes the applicability of in vitro and in vivo methods to assess drug transport to the brain. In vitro methods: culture of confluent monolayers of bovine brain endothelial cells which represent the blood-brain barrier (BBB) and confocal laser scanning microscopy. In vivo methods: BBB-clearance model and microdialysis in rats. Ascertaining selectivity in BBB-transport in disease states is emphasized.

Original language	English
Pages (from-to)	259-263
Number of pages	5
Journal	Journal of Controlled Release
Volume	28
Issue number	1-3
DOIs	https://doi.org/10.1016/0168-3659(94)90173-2
Publication status	Published - Jan 1994

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10.1016/0168-3659(94)90173-2

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title = "Drug transport to the brain: in vitro versus in vivo approaches",

abstract = "This paper summarizes the applicability of in vitro and in vivo methods to assess drug transport to the brain. In vitro methods: culture of confluent monolayers of bovine brain endothelial cells which represent the blood-brain barrier (BBB) and confocal laser scanning microscopy. In vivo methods: BBB-clearance model and microdialysis in rats. Ascertaining selectivity in BBB-transport in disease states is emphasized.",

keywords = "BBB-clearance model, Blood-brain barrier, Bovine brain endothelial cell, Confocal laser scanning microscopy, In vitro/in vivo method, Microdialysis",

author = "{de Boer}, {A. G.} and {de Vries}, {H. E.} and {de Lange}, {E. C.M.} and M. Danhof and J. Kuiper and Breimer, {D. D.}",

year = "1994",

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doi = "10.1016/0168-3659(94)90173-2",

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T2 - in vitro versus in vivo approaches

AU - de Boer, A. G.

AU - de Vries, H. E.

AU - de Lange, E. C.M.

AU - Danhof, M.

AU - Kuiper, J.

AU - Breimer, D. D.

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AB - This paper summarizes the applicability of in vitro and in vivo methods to assess drug transport to the brain. In vitro methods: culture of confluent monolayers of bovine brain endothelial cells which represent the blood-brain barrier (BBB) and confocal laser scanning microscopy. In vivo methods: BBB-clearance model and microdialysis in rats. Ascertaining selectivity in BBB-transport in disease states is emphasized.

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KW - Blood-brain barrier

KW - Bovine brain endothelial cell

KW - Confocal laser scanning microscopy

KW - In vitro/in vivo method

KW - Microdialysis

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VL - 28

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 1-3

ER -

Drug transport to the brain: in vitro versus in vivo approaches

Abstract

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