Durable coexistence of donor and recipient strains after fecal microbiota transplantation

Simone S Li, Ana Zhu, Vladimir Benes, Paul I Costea, Rajna Hercog, Falk Hildebrand, Jaime Huerta-Cepas, Max Nieuwdorp, Jarkko Salojärvi, Anita Y Voigt, Georg Zeller, Shinichi Sunagawa, Willem M de Vos, Peer Bork

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Fecal microbiota transplantation (FMT) has shown efficacy in treating recurrent Clostridium difficile infection and is increasingly being applied to other gastrointestinal disorders, yet the fate of native and introduced microbial strains remains largely unknown. To quantify the extent of donor microbiota colonization, we monitored strain populations in fecal samples from a recent FMT study on metabolic syndrome patients using single-nucleotide variants in metagenomes. We found extensive coexistence of donor and recipient strains, persisting 3 months after treatment. Colonization success was greater for conspecific strains than for new species, the latter falling within fluctuation levels observed in healthy individuals over a similar time frame. Furthermore, same-donor recipients displayed varying degrees of microbiota transfer, indicating individual patterns of microbiome resistance and donor-recipient compatibilities.

Original languageEnglish
Pages (from-to)586-9
Number of pages4
JournalScience
Volume352
Issue number6285
DOIs
Publication statusPublished - 29 Apr 2016

Cite this

Li, S. S., Zhu, A., Benes, V., Costea, P. I., Hercog, R., Hildebrand, F., ... Bork, P. (2016). Durable coexistence of donor and recipient strains after fecal microbiota transplantation. Science, 352(6285), 586-9. https://doi.org/10.1126/science.aad8852