Duration of fever and serious bacterial infections in children: a systematic review

Gijs Elshout, Miriam Monteny, Johannes C van der Wouden, Bart W Koes, Marjolein Y Berger

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

BACKGROUND: Parents of febrile children frequently contact primary care. Longer duration of fever has been related to increased risk for serious bacterial infections (SBI). However, the evidence for this association remains controversial. We assessed the predictive value of duration of fever for SBI.

METHODS: Studies from MEDLINE, Embase and Cochrane databases (from January 1991 to December 2009) were retrieved. We included studies describing children aged 2 months to 6 years in countries with high Haemophilus influenzae type b vaccination coverage. Duration of fever had to be studied as a predictor for serious bacterial infections.

RESULTS: Seven studies assessed the association between duration of fever and serious bacterial infections; three of these found a relationship.

CONCLUSION: The predictive value of duration of fever for identifying serious bacterial infections in children remains inconclusive. None of these seven studies was performed in primary care. Studies evaluating the duration of fever and its predictive value in children in primary care are required.

Original languageEnglish
Pages (from-to)33
JournalBMC Family Practice
Volume12
DOIs
Publication statusPublished - 16 May 2011

Cite this

Elshout, Gijs ; Monteny, Miriam ; van der Wouden, Johannes C ; Koes, Bart W ; Berger, Marjolein Y. / Duration of fever and serious bacterial infections in children : a systematic review. In: BMC Family Practice. 2011 ; Vol. 12. pp. 33.
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Duration of fever and serious bacterial infections in children : a systematic review. / Elshout, Gijs; Monteny, Miriam; van der Wouden, Johannes C; Koes, Bart W; Berger, Marjolein Y.

In: BMC Family Practice, Vol. 12, 16.05.2011, p. 33.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Duration of fever and serious bacterial infections in children

T2 - a systematic review

AU - Elshout, Gijs

AU - Monteny, Miriam

AU - van der Wouden, Johannes C

AU - Koes, Bart W

AU - Berger, Marjolein Y

PY - 2011/5/16

Y1 - 2011/5/16

N2 - BACKGROUND: Parents of febrile children frequently contact primary care. Longer duration of fever has been related to increased risk for serious bacterial infections (SBI). However, the evidence for this association remains controversial. We assessed the predictive value of duration of fever for SBI.METHODS: Studies from MEDLINE, Embase and Cochrane databases (from January 1991 to December 2009) were retrieved. We included studies describing children aged 2 months to 6 years in countries with high Haemophilus influenzae type b vaccination coverage. Duration of fever had to be studied as a predictor for serious bacterial infections.RESULTS: Seven studies assessed the association between duration of fever and serious bacterial infections; three of these found a relationship.CONCLUSION: The predictive value of duration of fever for identifying serious bacterial infections in children remains inconclusive. None of these seven studies was performed in primary care. Studies evaluating the duration of fever and its predictive value in children in primary care are required.

AB - BACKGROUND: Parents of febrile children frequently contact primary care. Longer duration of fever has been related to increased risk for serious bacterial infections (SBI). However, the evidence for this association remains controversial. We assessed the predictive value of duration of fever for SBI.METHODS: Studies from MEDLINE, Embase and Cochrane databases (from January 1991 to December 2009) were retrieved. We included studies describing children aged 2 months to 6 years in countries with high Haemophilus influenzae type b vaccination coverage. Duration of fever had to be studied as a predictor for serious bacterial infections.RESULTS: Seven studies assessed the association between duration of fever and serious bacterial infections; three of these found a relationship.CONCLUSION: The predictive value of duration of fever for identifying serious bacterial infections in children remains inconclusive. None of these seven studies was performed in primary care. Studies evaluating the duration of fever and its predictive value in children in primary care are required.

KW - Bacterial Infections/diagnosis

KW - Child

KW - Child, Preschool

KW - Fever/microbiology

KW - Humans

KW - Infant

KW - Predictive Value of Tests

KW - Time Factors

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DO - 10.1186/1471-2296-12-33

M3 - Review article

VL - 12

SP - 33

JO - BMC Family Practice

JF - BMC Family Practice

SN - 1471-2296

ER -