EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

EANO Executive Board and ESMO Guidelines Committee

doi:10.1016/j.annonc.2021.07.016

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

EANO Executive Board and ESMO Guidelines Committee

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Journal	Annals of Oncology
Early online date	2021
DOIs	https://doi.org/10.1016/j.annonc.2021.07.016
Publication status	E-pub ahead of print - 2021

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10.1016/j.annonc.2021.07.016

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@article{f4b2ecedbfd24728a45bb154d2939e43,

title = "EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours",

keywords = "central nervous system, cerebral, clinical practice, guideline, neurological, recommendations",

author = "{le Rhun}, E. and M. Guckenberger and M. Smits and R. Dummer and T. Bachelot and F. Sahm and N. Galldiks and {de Azambuja}, E. and Berghoff, {A. S.} and P. Metellus and S. Peters and Hong, {Y. K.} and F. Winkler and D. Schadendorf and {van den Bent}, M. and J. Seoane and R. Stahel and G. Minniti and {EANO Executive Board and ESMO Guidelines Committee} and P. Wesseling and M. Weller and M. Preusser",

note = "Funding Information: Manuscript editing support was provided by Sarah Escuin, Richard Lutz, Jennifer Lamarre and Catherine Evans (ESMO Guidelines staff). No external funding has been received for the preparation of these guidelines. Production costs have been covered by ESMO from central funds. ELR has received honoraria for lectures or advisory board from AbbVie, Adastra, Daiichi Sankyo, LEO Pharma, Seagen and Tocagen. MG has received honoraria for lectures or advisory board from AstraZeneca and has received research support from AstraZeneca and Varian. MS received honoraria for lectures from GE Healthcare and for trial imaging review from Parexel Ltd. RD has intermittent, project-focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dohme, Bristol-Myers Squibb, Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, CatalYm, Second Genome, Regeneron and Alligator. TB has received personal fees and non-financial support from Roche; grants, personal fees and non-financial support from Novartis, AstraZeneca and Pfizer; and grant and personal fees from Seattle Genetics. ASB has research support from Daiichi Sankyo and Roche and honoraria for lectures, consultation or advisory board participation from Roche, Bristol-Meyers Squibb, Merck and Daiichi Sankyo as well as travel support from Roche, Amgen and AbbVie. EdA has received honoraria and/or advisory board from Roche/GNE, Novartis, Seattle Genetics, Zodiac, Libbs, Lilly and Pierre Fabre; travel grants from Roche/GNE and GSK/Novartis; and research grants to her institution from Roche/GNE, AstraZeneca, GSK/Novartis and Servier. SP has received education grants, provided consultation, attended advisory boards, provided lectures for and received honoraria from AbbVie, Amgen, AstraZeneca, Bayer, Biocartis, Bioinvent, Blueprint Medicines, Boehringer-Ingelheim, Bristol-Myers Squibb, Clovis, Daiichi Sankyo, Debiopharm, Eli Lilly, F. Hoffmann-La Roche, Foundation Medicine, Illumina, Janssen, Merck Sharp & Dohme, Merck Serono, Merrimack, Novartis, PharmaMar, Pfizer, Regeneron, Sanofi, Seattle Genetics, Takeda and Vaccibody. FS has received advisory board for AbbVie, travel support from Agilent and Illumina and speaker's bureau from Agilent and Medac. DS reported consulting or advisory role for Roche/Genentech, Novartis, Bristol-Myers Squibb, MSD, Merck Serono, Amgen, Immunocore, Incyte, InFlarX, 4SC, Pierre Fabre, Mologen, Nektar and Sanofi/Regeneron; honoraria from Roche/Genentech, Novartis, MSD, Bristol-Myers Squibb, Merck Serono, Amgen, Immunocore, Incyte, 4SC, Pierre Fabre, Array BioPharma, Pfizer, Philogen and Regeneron; travel, accommodation and expenses from Roche/Genentech, Novartis, Bristol-Myers Squibb, Merck Serono, Amgen and Merck; speakers? bureau for Novartis, Bristol-Myers Squibb, MSD, Pierre Fabre and Roche; research funding from Novartis and Bristol-Myers Squibb; and steering committee member for Novartis, MSD and Bristol-Myers Squibb. JS is a co-founder of Mosaic Biomedicals and board member of Northern Biologics; he received grant/research support from Mosaic Biomedicals, Northern Biologics, Roche/Glycart, Isarna and Ridgeline. RS has received honoraria for lectures or advisory board from boards from MSD, Roche, Merck Serono, Celldex Therapeutics, Novartis, Mundipharma and Puma Technologies. MvdB has received honoraria for consultation from AbbVie, Agios, Carthera, Celgene, Bayer, Nerviano, Karyopharm and Boehringer. FW has received research grants from Roche, Genentech, Boehringer and Divide & Conquer Ltd. and honoraria from Divide & Conquer Ltd. MW has received research grants from AbbVie, Adastra, Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD) and Novocure and honoraria for lectures or advisory board participation or consulting from AbbVie, Basilea, Bristol Meyer Squibb (BMS), Celgene, Medac, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, Orbus, Roche and Tocagen. MP has received honoraria for lectures, consultation or advisory board participation from Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, AstraZeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome and Tocagen and reported clinical trials and contracted research (paid to his institution) from B?hringer-Ingelheim, Bristol-Myers Squibb, Roche, Daiichi Sankyo, Merck Sharp & Dohme, Novocure, GlaxoSmithKline and AbbVie. The remaining authors have declared no conflicts of interest. Funding Information: ELR has received honoraria for lectures or advisory board from AbbVie, Adastra, Daiichi Sankyo, LEO Pharma, Seagen and Tocagen. MG has received honoraria for lectures or advisory board from AstraZeneca and has received research support from AstraZeneca and Varian. MS received honoraria for lectures from GE Healthcare and for trial imaging review from Parexel Ltd. RD has intermittent, project-focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dohme, Bristol-Myers Squibb, Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, CatalYm, Second Genome, Regeneron and Alligator. TB has received personal fees and non-financial support from Roche; grants, personal fees and non-financial support from Novartis, AstraZeneca and Pfizer; and grant and personal fees from Seattle Genetics. ASB has research support from Daiichi Sankyo and Roche and honoraria for lectures, consultation or advisory board participation from Roche, Bristol-Meyers Squibb, Merck and Daiichi Sankyo as well as travel support from Roche, Amgen and AbbVie. EdA has received honoraria and/or advisory board from Roche/GNE, Novartis, Seattle Genetics, Zodiac, Libbs, Lilly and Pierre Fabre; travel grants from Roche/GNE and GSK/Novartis; and research grants to her institution from Roche/GNE, AstraZeneca, GSK/Novartis and Servier. SP has received education grants, provided consultation, attended advisory boards, provided lectures for and received honoraria from AbbVie, Amgen, AstraZeneca, Bayer, Biocartis, Bioinvent, Blueprint Medicines, Boehringer-Ingelheim, Bristol-Myers Squibb, Clovis, Daiichi Sankyo, Debiopharm, Eli Lilly, F. Hoffmann-La Roche, Foundation Medicine, Illumina, Janssen, Merck Sharp & Dohme, Merck Serono, Merrimack, Novartis, PharmaMar, Pfizer, Regeneron, Sanofi, Seattle Genetics, Takeda and Vaccibody. FS has received advisory board for AbbVie, travel support from Agilent and Illumina and speaker{\textquoteright}s bureau from Agilent and Medac. DS reported consulting or advisory role for Roche/Genentech, Novartis, Bristol-Myers Squibb, MSD, Merck Serono, Amgen, Immunocore, Incyte, InFlarX, 4SC, Pierre Fabre, Mologen, Nektar and Sanofi/Regeneron; honoraria from Roche/Genentech, Novartis, MSD, Bristol-Myers Squibb, Merck Serono, Amgen, Immunocore, Incyte, 4SC, Pierre Fabre, Array BioPharma, Pfizer, Philogen and Regeneron; travel, accommodation and expenses from Roche/Genentech, Novartis, Bristol-Myers Squibb, Merck Serono, Amgen and Merck; speakers{\textquoteright} bureau for Novartis, Bristol-Myers Squibb, MSD, Pierre Fabre and Roche; research funding from Novartis and Bristol-Myers Squibb; and steering committee member for Novartis, MSD and Bristol-Myers Squibb. JS is a co-founder of Mosaic Biomedicals and board member of Northern Biologics; he received grant/research support from Mosaic Biomedicals, Northern Biologics, Roche/Glycart, Isarna and Ridgeline. RS has received honoraria for lectures or advisory board from boards from MSD, Roche, Merck Serono, Celldex Therapeutics, Novartis, Mundipharma and Puma Technologies. MvdB has received honoraria for consultation from AbbVie, Agios, Carthera, Celgene, Bayer, Nerviano, Karyopharm and Boehringer. FW has received research grants from Roche, Genentech, Boehringer and Divide & Conquer Ltd. and honoraria from Divide & Conquer Ltd. MW has received research grants from AbbVie, Adastra, Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD) and Novocure and honoraria for lectures or advisory board participation or consulting from AbbVie, Basilea, Bristol Meyer Squibb (BMS), Celgene, Medac, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, Orbus, Roche and Tocagen. MP has received honoraria for lectures, consultation or advisory board participation from Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, AstraZeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome and Tocagen and reported clinical trials and contracted research (paid to his institution) from B{\"o}hringer-Ingelheim, Bristol-Myers Squibb, Roche, Daiichi Sankyo, Merck Sharp & Dohme, Novocure, GlaxoSmithKline and AbbVie. The remaining authors have declared no conflicts of interest. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

doi = "10.1016/j.annonc.2021.07.016",

language = "English",

journal = "Annals of Oncology",

issn = "0923-7534",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

AU - le Rhun, E.

AU - Guckenberger, M.

AU - Smits, M.

AU - Dummer, R.

AU - Bachelot, T.

AU - Sahm, F.

AU - Galldiks, N.

AU - de Azambuja, E.

AU - Berghoff, A. S.

AU - Metellus, P.

AU - Peters, S.

AU - Hong, Y. K.

AU - Winkler, F.

AU - Schadendorf, D.

AU - van den Bent, M.

AU - Seoane, J.

AU - Stahel, R.

AU - Minniti, G.

AU - EANO Executive Board and ESMO Guidelines Committee

AU - Wesseling, P.

AU - Weller, M.

AU - Preusser, M.

N1 - Funding Information: Manuscript editing support was provided by Sarah Escuin, Richard Lutz, Jennifer Lamarre and Catherine Evans (ESMO Guidelines staff). No external funding has been received for the preparation of these guidelines. Production costs have been covered by ESMO from central funds. ELR has received honoraria for lectures or advisory board from AbbVie, Adastra, Daiichi Sankyo, LEO Pharma, Seagen and Tocagen. MG has received honoraria for lectures or advisory board from AstraZeneca and has received research support from AstraZeneca and Varian. MS received honoraria for lectures from GE Healthcare and for trial imaging review from Parexel Ltd. RD has intermittent, project-focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dohme, Bristol-Myers Squibb, Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, CatalYm, Second Genome, Regeneron and Alligator. TB has received personal fees and non-financial support from Roche; grants, personal fees and non-financial support from Novartis, AstraZeneca and Pfizer; and grant and personal fees from Seattle Genetics. ASB has research support from Daiichi Sankyo and Roche and honoraria for lectures, consultation or advisory board participation from Roche, Bristol-Meyers Squibb, Merck and Daiichi Sankyo as well as travel support from Roche, Amgen and AbbVie. EdA has received honoraria and/or advisory board from Roche/GNE, Novartis, Seattle Genetics, Zodiac, Libbs, Lilly and Pierre Fabre; travel grants from Roche/GNE and GSK/Novartis; and research grants to her institution from Roche/GNE, AstraZeneca, GSK/Novartis and Servier. SP has received education grants, provided consultation, attended advisory boards, provided lectures for and received honoraria from AbbVie, Amgen, AstraZeneca, Bayer, Biocartis, Bioinvent, Blueprint Medicines, Boehringer-Ingelheim, Bristol-Myers Squibb, Clovis, Daiichi Sankyo, Debiopharm, Eli Lilly, F. Hoffmann-La Roche, Foundation Medicine, Illumina, Janssen, Merck Sharp & Dohme, Merck Serono, Merrimack, Novartis, PharmaMar, Pfizer, Regeneron, Sanofi, Seattle Genetics, Takeda and Vaccibody. FS has received advisory board for AbbVie, travel support from Agilent and Illumina and speaker's bureau from Agilent and Medac. DS reported consulting or advisory role for Roche/Genentech, Novartis, Bristol-Myers Squibb, MSD, Merck Serono, Amgen, Immunocore, Incyte, InFlarX, 4SC, Pierre Fabre, Mologen, Nektar and Sanofi/Regeneron; honoraria from Roche/Genentech, Novartis, MSD, Bristol-Myers Squibb, Merck Serono, Amgen, Immunocore, Incyte, 4SC, Pierre Fabre, Array BioPharma, Pfizer, Philogen and Regeneron; travel, accommodation and expenses from Roche/Genentech, Novartis, Bristol-Myers Squibb, Merck Serono, Amgen and Merck; speakers? bureau for Novartis, Bristol-Myers Squibb, MSD, Pierre Fabre and Roche; research funding from Novartis and Bristol-Myers Squibb; and steering committee member for Novartis, MSD and Bristol-Myers Squibb. JS is a co-founder of Mosaic Biomedicals and board member of Northern Biologics; he received grant/research support from Mosaic Biomedicals, Northern Biologics, Roche/Glycart, Isarna and Ridgeline. RS has received honoraria for lectures or advisory board from boards from MSD, Roche, Merck Serono, Celldex Therapeutics, Novartis, Mundipharma and Puma Technologies. MvdB has received honoraria for consultation from AbbVie, Agios, Carthera, Celgene, Bayer, Nerviano, Karyopharm and Boehringer. FW has received research grants from Roche, Genentech, Boehringer and Divide & Conquer Ltd. and honoraria from Divide & Conquer Ltd. MW has received research grants from AbbVie, Adastra, Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD) and Novocure and honoraria for lectures or advisory board participation or consulting from AbbVie, Basilea, Bristol Meyer Squibb (BMS), Celgene, Medac, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, Orbus, Roche and Tocagen. MP has received honoraria for lectures, consultation or advisory board participation from Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, AstraZeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome and Tocagen and reported clinical trials and contracted research (paid to his institution) from B?hringer-Ingelheim, Bristol-Myers Squibb, Roche, Daiichi Sankyo, Merck Sharp & Dohme, Novocure, GlaxoSmithKline and AbbVie. The remaining authors have declared no conflicts of interest. Funding Information: ELR has received honoraria for lectures or advisory board from AbbVie, Adastra, Daiichi Sankyo, LEO Pharma, Seagen and Tocagen. MG has received honoraria for lectures or advisory board from AstraZeneca and has received research support from AstraZeneca and Varian. MS received honoraria for lectures from GE Healthcare and for trial imaging review from Parexel Ltd. RD has intermittent, project-focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dohme, Bristol-Myers Squibb, Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, CatalYm, Second Genome, Regeneron and Alligator. TB has received personal fees and non-financial support from Roche; grants, personal fees and non-financial support from Novartis, AstraZeneca and Pfizer; and grant and personal fees from Seattle Genetics. ASB has research support from Daiichi Sankyo and Roche and honoraria for lectures, consultation or advisory board participation from Roche, Bristol-Meyers Squibb, Merck and Daiichi Sankyo as well as travel support from Roche, Amgen and AbbVie. EdA has received honoraria and/or advisory board from Roche/GNE, Novartis, Seattle Genetics, Zodiac, Libbs, Lilly and Pierre Fabre; travel grants from Roche/GNE and GSK/Novartis; and research grants to her institution from Roche/GNE, AstraZeneca, GSK/Novartis and Servier. SP has received education grants, provided consultation, attended advisory boards, provided lectures for and received honoraria from AbbVie, Amgen, AstraZeneca, Bayer, Biocartis, Bioinvent, Blueprint Medicines, Boehringer-Ingelheim, Bristol-Myers Squibb, Clovis, Daiichi Sankyo, Debiopharm, Eli Lilly, F. Hoffmann-La Roche, Foundation Medicine, Illumina, Janssen, Merck Sharp & Dohme, Merck Serono, Merrimack, Novartis, PharmaMar, Pfizer, Regeneron, Sanofi, Seattle Genetics, Takeda and Vaccibody. FS has received advisory board for AbbVie, travel support from Agilent and Illumina and speaker’s bureau from Agilent and Medac. DS reported consulting or advisory role for Roche/Genentech, Novartis, Bristol-Myers Squibb, MSD, Merck Serono, Amgen, Immunocore, Incyte, InFlarX, 4SC, Pierre Fabre, Mologen, Nektar and Sanofi/Regeneron; honoraria from Roche/Genentech, Novartis, MSD, Bristol-Myers Squibb, Merck Serono, Amgen, Immunocore, Incyte, 4SC, Pierre Fabre, Array BioPharma, Pfizer, Philogen and Regeneron; travel, accommodation and expenses from Roche/Genentech, Novartis, Bristol-Myers Squibb, Merck Serono, Amgen and Merck; speakers’ bureau for Novartis, Bristol-Myers Squibb, MSD, Pierre Fabre and Roche; research funding from Novartis and Bristol-Myers Squibb; and steering committee member for Novartis, MSD and Bristol-Myers Squibb. JS is a co-founder of Mosaic Biomedicals and board member of Northern Biologics; he received grant/research support from Mosaic Biomedicals, Northern Biologics, Roche/Glycart, Isarna and Ridgeline. RS has received honoraria for lectures or advisory board from boards from MSD, Roche, Merck Serono, Celldex Therapeutics, Novartis, Mundipharma and Puma Technologies. MvdB has received honoraria for consultation from AbbVie, Agios, Carthera, Celgene, Bayer, Nerviano, Karyopharm and Boehringer. FW has received research grants from Roche, Genentech, Boehringer and Divide & Conquer Ltd. and honoraria from Divide & Conquer Ltd. MW has received research grants from AbbVie, Adastra, Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD) and Novocure and honoraria for lectures or advisory board participation or consulting from AbbVie, Basilea, Bristol Meyer Squibb (BMS), Celgene, Medac, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, Orbus, Roche and Tocagen. MP has received honoraria for lectures, consultation or advisory board participation from Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, AstraZeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome and Tocagen and reported clinical trials and contracted research (paid to his institution) from Böhringer-Ingelheim, Bristol-Myers Squibb, Roche, Daiichi Sankyo, Merck Sharp & Dohme, Novocure, GlaxoSmithKline and AbbVie. The remaining authors have declared no conflicts of interest. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

KW - central nervous system

KW - cerebral

KW - clinical practice

KW - guideline

KW - neurological

KW - recommendations

UR - http://www.scopus.com/inward/record.url?scp=85114662933&partnerID=8YFLogxK

U2 - 10.1016/j.annonc.2021.07.016

DO - 10.1016/j.annonc.2021.07.016

M3 - Article

C2 - 34364998

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

ER -

EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours

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