We determined the aneuploidy detection rate achievable by early pregnancy screening with pregnancy associated plasma protein (PAPP)-A, free β human chorionic gonadotrophin (hCG) and ultrasound nuchal translucency (NT) measurement. Women having prenatal diagnosis were scanned, and a blood sample was taken and stored. Stored samples were tested and a total of 37 were found to have Down syndrome, 8 to have Edwards syndrome and 255 were controls. Results were expressed in multiples of the gestation-specific median (MOM) value in the controls after regression and, for the serum markers, maternal weight adjustment. In Down syndrome the medians were for PAPP-A 0.63 MOM (95 per cent confidence interval (CI) 0.45-0.87); free β-hCG 1.88 MOM (1.33-2.66); and NT 2.34 MOM (1.70-3.22). Using these parameters the expected detection rate for a 5 per cent false-positive rate for different marker combinations were: 55.3 per cent for PAPP-A and free β-hCG, 68.4 per cent for NT alone; and 84.6 per cent for PAPP-A, free β-hCG and NT. The median values for Edwards syndrome were: 0.17 MOM for PAPP-A; 0.18 MOM for free β-hCG; and 2.64 MOM for NT. Early pregnancy screening with the combined measurement of maternal serum PAPP-A and free β-hCG and fetal nuchal translucency could achieve a high Down syndrome detection rate.
|Publication status||Published - 1999|
de Graaf, I. M., Pajkrt, E., Bilardo, C. M., Leschot, N. J., Cuckle, H. S., & van Lith, J. M. M. (1999). Early pregnancy screening for fetal aneuploidy with serum markers and nuchal translucency. Prenatal Diagnosis, 19(5), 458-462. https://doi.org/10.1002/(SICI)1097-0223(199905)19:5<458::AID-PD569>3.0.CO;2-A