Early switching of antibiotic therapy from intravenous to oral using a combination of education, pocket-sized cards and switch advice: A practical intervention resulting in a reduction in length of hospital stay

Anne-Marie A Mouwen, Jacob A Dijkstra, Eefje Jong, Patricia C A M Buijtels, Pieternel C M Pasker-de Jong, J Elsbeth Nagtegaal

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVES: To assess the effectiveness of a combined intervention on the moment and rate of switching from intravenous (IV) to oral antibiotic therapy.

MATERIALS AND METHODS: The study used a historically controlled prospective intervention design. Interventions consisted of educating physicians, handing out pocket-sized cards and providing switch advice in the electronic patient record. All patients hospitalized at the surgery department who were treated with IV antibiotics for 24 hours or longer and fulfilled the switch criteria within 72 hours of IV treatment were included. Outcomes before and during the intervention were compared.

RESULTS: An early IV to oral switch took place in 35.4% (35/99) of the antibiotic courses in the baseline period and in 67.7% (42/62) of the antibiotic courses in the intervention period (odds ratio 3.84, 95% confidence interval 1.96 - 7.53). Duration of IV therapy was significantly reduced from 5 to 3 days (p<0.01). Length of hospitalization was reduced from 6 to 5 days (p<0.05).

CONCLUSIONS: The intervention methods were effective in promoting an early IV to oral antibiotic switch by shortening the length of IV therapy and hospital stay.

Original languageEnglish
JournalInternational Journal of Antimicrobial Agents
DOIs
Publication statusE-pub ahead of print - 27 Jul 2019

Cite this

@article{01500abbfda3405e8380a43ac29db78b,
title = "Early switching of antibiotic therapy from intravenous to oral using a combination of education, pocket-sized cards and switch advice: A practical intervention resulting in a reduction in length of hospital stay",
abstract = "OBJECTIVES: To assess the effectiveness of a combined intervention on the moment and rate of switching from intravenous (IV) to oral antibiotic therapy.MATERIALS AND METHODS: The study used a historically controlled prospective intervention design. Interventions consisted of educating physicians, handing out pocket-sized cards and providing switch advice in the electronic patient record. All patients hospitalized at the surgery department who were treated with IV antibiotics for 24 hours or longer and fulfilled the switch criteria within 72 hours of IV treatment were included. Outcomes before and during the intervention were compared.RESULTS: An early IV to oral switch took place in 35.4{\%} (35/99) of the antibiotic courses in the baseline period and in 67.7{\%} (42/62) of the antibiotic courses in the intervention period (odds ratio 3.84, 95{\%} confidence interval 1.96 - 7.53). Duration of IV therapy was significantly reduced from 5 to 3 days (p<0.01). Length of hospitalization was reduced from 6 to 5 days (p<0.05).CONCLUSIONS: The intervention methods were effective in promoting an early IV to oral antibiotic switch by shortening the length of IV therapy and hospital stay.",
author = "Mouwen, {Anne-Marie A} and Dijkstra, {Jacob A} and Eefje Jong and Buijtels, {Patricia C A M} and {Pasker-de Jong}, {Pieternel C M} and Nagtegaal, {J Elsbeth}",
note = "Copyright {\circledC} 2019. Published by Elsevier B.V.",
year = "2019",
month = "7",
day = "27",
doi = "10.1016/j.ijantimicag.2019.07.020",
language = "English",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier",

}

Early switching of antibiotic therapy from intravenous to oral using a combination of education, pocket-sized cards and switch advice : A practical intervention resulting in a reduction in length of hospital stay. / Mouwen, Anne-Marie A; Dijkstra, Jacob A; Jong, Eefje; Buijtels, Patricia C A M; Pasker-de Jong, Pieternel C M; Nagtegaal, J Elsbeth.

In: International Journal of Antimicrobial Agents, 27.07.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Early switching of antibiotic therapy from intravenous to oral using a combination of education, pocket-sized cards and switch advice

T2 - A practical intervention resulting in a reduction in length of hospital stay

AU - Mouwen, Anne-Marie A

AU - Dijkstra, Jacob A

AU - Jong, Eefje

AU - Buijtels, Patricia C A M

AU - Pasker-de Jong, Pieternel C M

AU - Nagtegaal, J Elsbeth

N1 - Copyright © 2019. Published by Elsevier B.V.

PY - 2019/7/27

Y1 - 2019/7/27

N2 - OBJECTIVES: To assess the effectiveness of a combined intervention on the moment and rate of switching from intravenous (IV) to oral antibiotic therapy.MATERIALS AND METHODS: The study used a historically controlled prospective intervention design. Interventions consisted of educating physicians, handing out pocket-sized cards and providing switch advice in the electronic patient record. All patients hospitalized at the surgery department who were treated with IV antibiotics for 24 hours or longer and fulfilled the switch criteria within 72 hours of IV treatment were included. Outcomes before and during the intervention were compared.RESULTS: An early IV to oral switch took place in 35.4% (35/99) of the antibiotic courses in the baseline period and in 67.7% (42/62) of the antibiotic courses in the intervention period (odds ratio 3.84, 95% confidence interval 1.96 - 7.53). Duration of IV therapy was significantly reduced from 5 to 3 days (p<0.01). Length of hospitalization was reduced from 6 to 5 days (p<0.05).CONCLUSIONS: The intervention methods were effective in promoting an early IV to oral antibiotic switch by shortening the length of IV therapy and hospital stay.

AB - OBJECTIVES: To assess the effectiveness of a combined intervention on the moment and rate of switching from intravenous (IV) to oral antibiotic therapy.MATERIALS AND METHODS: The study used a historically controlled prospective intervention design. Interventions consisted of educating physicians, handing out pocket-sized cards and providing switch advice in the electronic patient record. All patients hospitalized at the surgery department who were treated with IV antibiotics for 24 hours or longer and fulfilled the switch criteria within 72 hours of IV treatment were included. Outcomes before and during the intervention were compared.RESULTS: An early IV to oral switch took place in 35.4% (35/99) of the antibiotic courses in the baseline period and in 67.7% (42/62) of the antibiotic courses in the intervention period (odds ratio 3.84, 95% confidence interval 1.96 - 7.53). Duration of IV therapy was significantly reduced from 5 to 3 days (p<0.01). Length of hospitalization was reduced from 6 to 5 days (p<0.05).CONCLUSIONS: The intervention methods were effective in promoting an early IV to oral antibiotic switch by shortening the length of IV therapy and hospital stay.

U2 - 10.1016/j.ijantimicag.2019.07.020

DO - 10.1016/j.ijantimicag.2019.07.020

M3 - Article

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

ER -