Early warning indicators for population-based monitoring of HIV drug resistance in 6 African countries

Kim C.E. Sigaloff*, Raph L. Hamers, Jack Menke, Moheb Labib, Margaret Siwale, Prudence Ive, Mariette E. Botes, Cissy Kityo, Kishor Mandaliya, Maureen Wellington, Akin Osibogun, Ronald B. Geskus, Wendy S. Stevens, Michle Van Vugt, Tobias F.Rinke De Wit

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Human immunodeficiency virus (HIV) RNA testing and HIV drug resistance (HIVDR) testing are not routinely available for therapeutic monitoring of patients receiving antiretroviral therapy (ART) in resource-limited settings. World Health Organization HIVDR early warning indicators (EWIs) assess ART site factors known to favor the emergence of HIVDR. HIV drug resistance EWI monitoring was performed within the PharmAccess African Studies to Evaluate Resistance Monitoring (PASER-M) study, comprising 13 ART sites in 6 African countries. Early warning indicator assessment in the PASER network identified vulnerable aspects of ART programs and triggered interventions aimed at minimizing HIVDR emergence. Additionally, data suggest an advantage of medication possession ratio over on-time antiretroviral drug pickup in identifying patients at risk for HIVDR development.

Original languageEnglish
JournalClinical Infectious Diseases
Volume54
Issue numberSUPPL. 4
DOIs
Publication statusPublished - 15 May 2012

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