Abstract
Objective. To study whether an algorithm that includes additional diagnostic information could increase the specificity of the 14-3-3 protein testing in patients suspected to suffer from Creutzfeldt-Jakob disease (CJD). Design. The development of a diagnostic algorithm. Method. The 14-3-3 protein was tested in the cerebrospinal fluid from 69 consecutive patients suspected of having CJD. On the basis of a former study and literature research, a diagnostic algorithm was constructed, which restricted the indication for performing the 14-3-3 protein test. Results. By taking into consideration the findings of neuroimaging and routine cerebrospinal fluid examination prior to 14-3-3 testing, the specificity increased to 97% (95%-Cl: 85.5-99.9) thus changing the prior probability of having CJD of 35% to a posterior probability of 75-100%, in the case of a positive test result. Conclusion. Determining the presence of 14-3-3 protein is a highly sensitive and specific marker for sporadic CJD when used in combination with imaging and cerebrospinal fluid examination.
| Translated title of the contribution | A clinical algorithm for the use of the cerebrospinal fluid test on 14-3-3 protein for diagnostic investigation of Creutzfeldt-Jakob disease |
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| Original language | Dutch |
| Pages (from-to) | 1467-1471 |
| Number of pages | 5 |
| Journal | Nederlands Tijdschrift voor Geneeskunde |
| Volume | 145 |
| Issue number | 30 |
| Publication status | Published - 28 Jul 2001 |
| Externally published | Yes |