Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor

G van der Werf; F H Menko; J J Gille; P J van Diest; C J van Groeningen

Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor

Translated title of the contribution: Patient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor

G van der Werf, F H Menko, J J Gille, P J van Diest, C J van Groeningen

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

Translated title of the contribution	Patient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor
Original language	Dutch
Pages (from-to)	667-70
Number of pages	4
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	144
Issue number	14
Publication status	Published - 1 Apr 2000

Cite this

@article{c0e7c9264aee400fa8202c5af6223792,

title = "Een pati{\"e}nt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor",

abstract = "In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.",

keywords = "Adenocarcinoma/etiology, Adult, Genetic Predisposition to Disease, Hamartoma/etiology, Humans, Intestinal Neoplasms/etiology, Liver Neoplasms/etiology, Male, Neoplasms, Unknown Primary/genetics, Peutz-Jeghers Syndrome/complications, Thrombophlebitis/etiology",

author = "{van der Werf}, G and Menko, {F H} and Gille, {J J} and {van Diest}, {P J} and {van Groeningen}, {C J}",

year = "2000",

month = apr,

day = "1",

language = "Dutch",

volume = "144",

pages = "667--70",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu van Loghum",

number = "14",

}

TY - JOUR

T1 - Een patiënt met het Peutz-Jeghers-syndroom en levermetastasen van een onbekende primaire tumor

AU - van der Werf, G

AU - Menko, F H

AU - Gille, J J

AU - van Diest, P J

AU - van Groeningen, C J

PY - 2000/4/1

Y1 - 2000/4/1

N2 - In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

AB - In a 35-year old man with deep venous thrombosis liver metastases of an adenocarcinoma were observed. The primary tumour was not found. The patient had pigmentations on the lips and hamartomatous polyposis of the intestine. These findings indicate Peutz-Jeghers syndrome. In this syndrome there is an increased risk of, notably, gastrointestinal malignancy at an early age. Recent investigations have shown that Peutz-Jeghers syndrome is associated with a mutation in the STK11 gene on chromosome 19.

KW - Adenocarcinoma/etiology

KW - Adult

KW - Genetic Predisposition to Disease

KW - Hamartoma/etiology

KW - Humans

KW - Intestinal Neoplasms/etiology

KW - Liver Neoplasms/etiology

KW - Male

KW - Neoplasms, Unknown Primary/genetics

KW - Peutz-Jeghers Syndrome/complications

KW - Thrombophlebitis/etiology

M3 - Review article

C2 - 10774296

VL - 144

SP - 667

EP - 670

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

SN - 0028-2162

IS - 14

ER -