Effect of a pharmacological intervention on quality of life in patients with obsessive-compulsive disorder

Nienke H. Tenney*, Damiaan A.J.P. Denys, Harold J.G.M. Van Megen, Gerrit Glas, Herman G.M. Westenberg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Patients with obsessive-compulsive disorder (OCD) not only suffer from obsessive-compulsive symptoms, but also the disorder is associated with aberrant social functioning and a diminished quality of life (QoL). Although studies concerning the effect of treatment interventions on symptoms are common, studies with regard to the effect of treatment interventions on QoL are scarce. We examined the effect of a pharmacological intervention on QoL in 150 patients with OCD. Furthermore, we studied whether two different drugs, venlafaxine and paroxetine, differed in their effect on QoL. Finally, we examined whether any found improvement in QoL was related to improvement in symptoms and/or the baseline self-directedness score, which is one of the character dimensions of the psychobiological model of Cloninger. We demonstrated that QoL, as assessed with the Lancashire Quality of Life Profile, improved following pharmacological intervention, for which paroxetine and venlafaxine appeared to be equally effective. Furthermore, neither improvement in symptoms, nor baseline self-directedness, was associated with the improvement in QoL.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalInternational Clinical Psychopharmacology
Issue number1
Publication statusPublished - 1 Jan 2003

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