Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome

Arja Suzanne Vink, Sally-Ann B. Clur, Arthur A. M. Wilde, Nico A. Blom

Research output: Contribution to journalReview articleAcademicpeer-review


Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.
Original languageEnglish
Pages (from-to)64-75
JournalTrends in cardiovascular medicine
Issue number1
Publication statusPublished - 2018
Externally publishedYes

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