TY - JOUR
T1 - Effect of chronic somatic diseases on the course of late-life depression
AU - Hegeman, Johanna M.
AU - van Fenema, Esther M.
AU - Comijs, Hannie C.
AU - Kok, Rob M.
AU - van der Mast, Roos C.
AU - de Waal, Margot W.M.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Objective: To examine the influence of specific chronic somatic diseases and overall somatic diseases burden on the course of depression in older persons. Methods: This was a prospective cohort study with a 2-year follow-up. Participants were depressed persons (n = 285) from the Netherlands Study of Depression in Older Persons. The presence of chronic somatic diseases was based on self-report. Diagnosis of depression was assessed with the Composite International Diagnostic Interview, and severity of depression was measured with the Inventory of Depressive Symptomatology Self-report. Results: Cardiovascular diseases (odds ratio [OR] = 1.67, 95% confidence interval [CI] = 1.02–2.72, p = 0.041), musculoskeletal diseases (OR = 1.71, 95% CI = 1.04–2.80, p = 0.034), and the number of chronic somatic diseases (OR = 1.37, 95% CI = 1.16–1.63, p < 0.001) were associated with having a depressive disorder at 2-year follow-up. Furthermore, chronic non-specific lung diseases, cardiovascular diseases, musculoskeletal diseases, cancer, or cumulative somatic disease burden were associated with a chronic course of depression. Conclusions: Somatic disease burden is associated with a poor course of late-life depression. The course of late-life depression is particularly unfavorable in the presence of chronic non-specific lung diseases, cardiovascular diseases, musculoskeletal diseases, and cancer.
AB - Objective: To examine the influence of specific chronic somatic diseases and overall somatic diseases burden on the course of depression in older persons. Methods: This was a prospective cohort study with a 2-year follow-up. Participants were depressed persons (n = 285) from the Netherlands Study of Depression in Older Persons. The presence of chronic somatic diseases was based on self-report. Diagnosis of depression was assessed with the Composite International Diagnostic Interview, and severity of depression was measured with the Inventory of Depressive Symptomatology Self-report. Results: Cardiovascular diseases (odds ratio [OR] = 1.67, 95% confidence interval [CI] = 1.02–2.72, p = 0.041), musculoskeletal diseases (OR = 1.71, 95% CI = 1.04–2.80, p = 0.034), and the number of chronic somatic diseases (OR = 1.37, 95% CI = 1.16–1.63, p < 0.001) were associated with having a depressive disorder at 2-year follow-up. Furthermore, chronic non-specific lung diseases, cardiovascular diseases, musculoskeletal diseases, cancer, or cumulative somatic disease burden were associated with a chronic course of depression. Conclusions: Somatic disease burden is associated with a poor course of late-life depression. The course of late-life depression is particularly unfavorable in the presence of chronic non-specific lung diseases, cardiovascular diseases, musculoskeletal diseases, and cancer.
KW - chronic somatic diseases
KW - chronicity
KW - course
KW - depression
KW - late-life
UR - http://www.scopus.com/inward/record.url?scp=84977085528&partnerID=8YFLogxK
U2 - 10.1002/gps.4523
DO - 10.1002/gps.4523
M3 - Article
C2 - 27273023
AN - SCOPUS:84977085528
VL - 32
SP - 779
EP - 787
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 7
ER -