Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies

Luc Dirix; Helen Swaisland; Henk M. W. Verheul; Sylvie Rottey; Karin Leunen; Guy Jerusalem; Christian Rolfo; Dorte Nielsen; L. Rhoda Molife; Rebecca Kristeleit; Judith de Vos-Geelen; Morten Mau-Sorensen; Patricia Soetekouw; Carla van Herpen; Anitra Fielding; Karen So; Wendy Bannister; Ruth Plummer

doi:10.1016/j.clinthera.2016.08.010

Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies

Luc Dirix, Helen Swaisland, Henk M. W. Verheul, Sylvie Rottey, Karin Leunen, Guy Jerusalem, Christian Rolfo, Dorte Nielsen, L. Rhoda Molife, Rebecca Kristeleit, Judith de Vos-Geelen, Morten Mau-Sorensen, Patricia Soetekouw, Carla van Herpen, Anitra Fielding, Karen So, Wendy Bannister, Ruth Plummer

Medical oncology

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	2286-2299
Journal	Clinical Therapeutics
Volume	38
Issue number	10
DOIs	https://doi.org/10.1016/j.clinthera.2016.08.010
Publication status	Published - Oct 2016

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10.1016/j.clinthera.2016.08.010

Cite this

Dirix, L., Swaisland, H., Verheul, H. M. W., Rottey, S., Leunen, K., Jerusalem, G., Rolfo, C., Nielsen, D., Molife, L. R., Kristeleit, R., de Vos-Geelen, J., Mau-Sorensen, M., Soetekouw, P., van Herpen, C., Fielding, A., So, K., Bannister, W., & Plummer, R. (2016). Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies. Clinical Therapeutics, 38(10), 2286-2299. https://doi.org/10.1016/j.clinthera.2016.08.010

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title = "Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies",

keywords = "CYP3A4, itraconazole, olaparib, pharmacokinetic, rifampin",

author = "Luc Dirix and Helen Swaisland and Verheul, {Henk M. W.} and Sylvie Rottey and Karin Leunen and Guy Jerusalem and Christian Rolfo and Dorte Nielsen and Molife, {L. Rhoda} and Rebecca Kristeleit and {de Vos-Geelen}, Judith and Morten Mau-Sorensen and Patricia Soetekouw and {van Herpen}, Carla and Anitra Fielding and Karen So and Wendy Bannister and Ruth Plummer",

year = "2016",

month = oct,

doi = "10.1016/j.clinthera.2016.08.010",

language = "English",

volume = "38",

pages = "2286--2299",

journal = "Clinical Therapeutics",

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Dirix, L, Swaisland, H, Verheul, HMW, Rottey, S, Leunen, K, Jerusalem, G, Rolfo, C, Nielsen, D, Molife, LR, Kristeleit, R, de Vos-Geelen, J, Mau-Sorensen, M, Soetekouw, P, van Herpen, C, Fielding, A, So, K, Bannister, W & Plummer, R 2016, 'Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies', Clinical Therapeutics, vol. 38, no. 10, pp. 2286-2299. https://doi.org/10.1016/j.clinthera.2016.08.010

TY - JOUR

T1 - Effect of Itraconazole and Rifampin on the Pharmacokinetics of Olaparib in Patients With Advanced Solid Tumors: Results of Two Phase I Open-label Studies

AU - Dirix, Luc

AU - Swaisland, Helen

AU - Verheul, Henk M. W.

AU - Rottey, Sylvie

AU - Leunen, Karin

AU - Jerusalem, Guy

AU - Rolfo, Christian

AU - Nielsen, Dorte

AU - Molife, L. Rhoda

AU - Kristeleit, Rebecca

AU - de Vos-Geelen, Judith

AU - Mau-Sorensen, Morten

AU - Soetekouw, Patricia

AU - van Herpen, Carla

AU - Fielding, Anitra

AU - So, Karen

AU - Bannister, Wendy

AU - Plummer, Ruth

PY - 2016/10

Y1 - 2016/10

KW - CYP3A4

KW - itraconazole

KW - olaparib

KW - pharmacokinetic

KW - rifampin

U2 - 10.1016/j.clinthera.2016.08.010

DO - 10.1016/j.clinthera.2016.08.010

M3 - Article

C2 - 27745744

SN - 0149-2918

VL - 38

SP - 2286

EP - 2299

JO - Clinical Therapeutics

JF - Clinical Therapeutics

IS - 10

ER -