Effect of stent implantation on blood pressure control in adults with coarctation of the aorta

Jennifer J. van der Burg, Evangeline G. Warmerdam, Gregor J. Krings, Folkert J. Meijboom, Arie P. van Dijk, M. C. Post, Gerrit Veen, Michiel Voskuil, Gertjan Tj. Sieswerda

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Stenting of coarctation of the aorta (CoA) generally results in good angiographic results and a decrease in transcoarctation pressure gradient. However, effect on blood pressure control is less clear. The goal of the current retrospective analysis was to investigate the effects of CoA stenting on blood pressure control. Methods: A retrospective analysis was conducted in consecutive adult patients with a CoA who underwent a percutaneous intervention at one of the three participating hospitals. Measurements included office blood pressure, invasive peak-to-peak systolic pressure over the CoA, diameter of the intima lumen at the narrowest part of the CoA and use of medication. The follow-up data were obtained, based on the most recent examination date. Results: There were 26 native CoA and 17 recurrent CoAs (total n = 43). Seven of them underwent two procedures. Mean peak-to-peak gradient decreased from 27 mmHg to 3 mmHg (p < 0.001), and minimal diameter increased from a mean of 11 mm to 18 mm (p < 0.001). Mean systolic blood pressure decreased from 151 ± 18 mmHg to 135 ± 19 mmHg at first follow-up of 3.8 ± 1.9 months and 137 ± 22 mmHg at latest follow-up of 19.5 ± 10.9 months (p = 0.001 and p = 0.009, compared to baseline, respectively). The total number of hypertensive patients decreased from 74% to 27% at latest follow-up. No significant change in antihypertensive medication was observed. Conclusion: A clinically significant decrease in systolic blood pressure of approximately 16 mmHg was shown after (re)intervention in CoA patients, which sustained at follow-up. This sustained decrease of blood pressure can be expected to lead to less future adverse cardiovascular events.
Original languageEnglish
Pages (from-to)944-950
Number of pages7
JournalCardiovasc. Revascularization Med.
Volume19
Issue number8
Early online date2018
DOIs
Publication statusPublished - 1 Dec 2018

Cite this

van der Burg, J. J., Warmerdam, E. G., Krings, G. J., Meijboom, F. J., van Dijk, A. P., Post, M. C., ... Sieswerda, G. T. (2018). Effect of stent implantation on blood pressure control in adults with coarctation of the aorta. Cardiovasc. Revascularization Med., 19(8), 944-950. https://doi.org/10.1016/j.carrev.2018.03.018
van der Burg, Jennifer J. ; Warmerdam, Evangeline G. ; Krings, Gregor J. ; Meijboom, Folkert J. ; van Dijk, Arie P. ; Post, M. C. ; Veen, Gerrit ; Voskuil, Michiel ; Sieswerda, Gertjan Tj. / Effect of stent implantation on blood pressure control in adults with coarctation of the aorta. In: Cardiovasc. Revascularization Med. 2018 ; Vol. 19, No. 8. pp. 944-950.
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title = "Effect of stent implantation on blood pressure control in adults with coarctation of the aorta",
abstract = "Background: Stenting of coarctation of the aorta (CoA) generally results in good angiographic results and a decrease in transcoarctation pressure gradient. However, effect on blood pressure control is less clear. The goal of the current retrospective analysis was to investigate the effects of CoA stenting on blood pressure control. Methods: A retrospective analysis was conducted in consecutive adult patients with a CoA who underwent a percutaneous intervention at one of the three participating hospitals. Measurements included office blood pressure, invasive peak-to-peak systolic pressure over the CoA, diameter of the intima lumen at the narrowest part of the CoA and use of medication. The follow-up data were obtained, based on the most recent examination date. Results: There were 26 native CoA and 17 recurrent CoAs (total n = 43). Seven of them underwent two procedures. Mean peak-to-peak gradient decreased from 27 mmHg to 3 mmHg (p < 0.001), and minimal diameter increased from a mean of 11 mm to 18 mm (p < 0.001). Mean systolic blood pressure decreased from 151 ± 18 mmHg to 135 ± 19 mmHg at first follow-up of 3.8 ± 1.9 months and 137 ± 22 mmHg at latest follow-up of 19.5 ± 10.9 months (p = 0.001 and p = 0.009, compared to baseline, respectively). The total number of hypertensive patients decreased from 74{\%} to 27{\%} at latest follow-up. No significant change in antihypertensive medication was observed. Conclusion: A clinically significant decrease in systolic blood pressure of approximately 16 mmHg was shown after (re)intervention in CoA patients, which sustained at follow-up. This sustained decrease of blood pressure can be expected to lead to less future adverse cardiovascular events.",
author = "{van der Burg}, {Jennifer J.} and Warmerdam, {Evangeline G.} and Krings, {Gregor J.} and Meijboom, {Folkert J.} and {van Dijk}, {Arie P.} and Post, {M. C.} and Gerrit Veen and Michiel Voskuil and Sieswerda, {Gertjan Tj.}",
year = "2018",
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van der Burg, JJ, Warmerdam, EG, Krings, GJ, Meijboom, FJ, van Dijk, AP, Post, MC, Veen, G, Voskuil, M & Sieswerda, GT 2018, 'Effect of stent implantation on blood pressure control in adults with coarctation of the aorta' Cardiovasc. Revascularization Med., vol. 19, no. 8, pp. 944-950. https://doi.org/10.1016/j.carrev.2018.03.018

Effect of stent implantation on blood pressure control in adults with coarctation of the aorta. / van der Burg, Jennifer J.; Warmerdam, Evangeline G.; Krings, Gregor J.; Meijboom, Folkert J.; van Dijk, Arie P.; Post, M. C.; Veen, Gerrit; Voskuil, Michiel; Sieswerda, Gertjan Tj.

In: Cardiovasc. Revascularization Med., Vol. 19, No. 8, 01.12.2018, p. 944-950.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effect of stent implantation on blood pressure control in adults with coarctation of the aorta

AU - van der Burg, Jennifer J.

AU - Warmerdam, Evangeline G.

AU - Krings, Gregor J.

AU - Meijboom, Folkert J.

AU - van Dijk, Arie P.

AU - Post, M. C.

AU - Veen, Gerrit

AU - Voskuil, Michiel

AU - Sieswerda, Gertjan Tj.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Stenting of coarctation of the aorta (CoA) generally results in good angiographic results and a decrease in transcoarctation pressure gradient. However, effect on blood pressure control is less clear. The goal of the current retrospective analysis was to investigate the effects of CoA stenting on blood pressure control. Methods: A retrospective analysis was conducted in consecutive adult patients with a CoA who underwent a percutaneous intervention at one of the three participating hospitals. Measurements included office blood pressure, invasive peak-to-peak systolic pressure over the CoA, diameter of the intima lumen at the narrowest part of the CoA and use of medication. The follow-up data were obtained, based on the most recent examination date. Results: There were 26 native CoA and 17 recurrent CoAs (total n = 43). Seven of them underwent two procedures. Mean peak-to-peak gradient decreased from 27 mmHg to 3 mmHg (p < 0.001), and minimal diameter increased from a mean of 11 mm to 18 mm (p < 0.001). Mean systolic blood pressure decreased from 151 ± 18 mmHg to 135 ± 19 mmHg at first follow-up of 3.8 ± 1.9 months and 137 ± 22 mmHg at latest follow-up of 19.5 ± 10.9 months (p = 0.001 and p = 0.009, compared to baseline, respectively). The total number of hypertensive patients decreased from 74% to 27% at latest follow-up. No significant change in antihypertensive medication was observed. Conclusion: A clinically significant decrease in systolic blood pressure of approximately 16 mmHg was shown after (re)intervention in CoA patients, which sustained at follow-up. This sustained decrease of blood pressure can be expected to lead to less future adverse cardiovascular events.

AB - Background: Stenting of coarctation of the aorta (CoA) generally results in good angiographic results and a decrease in transcoarctation pressure gradient. However, effect on blood pressure control is less clear. The goal of the current retrospective analysis was to investigate the effects of CoA stenting on blood pressure control. Methods: A retrospective analysis was conducted in consecutive adult patients with a CoA who underwent a percutaneous intervention at one of the three participating hospitals. Measurements included office blood pressure, invasive peak-to-peak systolic pressure over the CoA, diameter of the intima lumen at the narrowest part of the CoA and use of medication. The follow-up data were obtained, based on the most recent examination date. Results: There were 26 native CoA and 17 recurrent CoAs (total n = 43). Seven of them underwent two procedures. Mean peak-to-peak gradient decreased from 27 mmHg to 3 mmHg (p < 0.001), and minimal diameter increased from a mean of 11 mm to 18 mm (p < 0.001). Mean systolic blood pressure decreased from 151 ± 18 mmHg to 135 ± 19 mmHg at first follow-up of 3.8 ± 1.9 months and 137 ± 22 mmHg at latest follow-up of 19.5 ± 10.9 months (p = 0.001 and p = 0.009, compared to baseline, respectively). The total number of hypertensive patients decreased from 74% to 27% at latest follow-up. No significant change in antihypertensive medication was observed. Conclusion: A clinically significant decrease in systolic blood pressure of approximately 16 mmHg was shown after (re)intervention in CoA patients, which sustained at follow-up. This sustained decrease of blood pressure can be expected to lead to less future adverse cardiovascular events.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/29752138

U2 - 10.1016/j.carrev.2018.03.018

DO - 10.1016/j.carrev.2018.03.018

M3 - Article

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SP - 944

EP - 950

JO - Cardiovasc. Revascularization Med.

JF - Cardiovasc. Revascularization Med.

SN - 1553-8389

IS - 8

ER -