Effective Treatment for Rapid Improvement of Both Disease Activity and Self-Reported Physical Activity in Early Rheumatoid Arthritis

Nicole P. C. Konijn, Lilian H. D. van Tuyl, Maarten Boers, Debby den Uyl, Marieke M. ter Wee, Pit Kerstens, AE Voskuyl, Michael Nurmohamed, Dirkjan van Schaardenburg, Willem F. Lems

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: To investigate the longitudinal relationship between disease activity and self-reported physical activity (PA) in patients with early rheumatoid arthritis during the first year of treatment with combination therapy.

METHODS: PA was measured with the Short Questionnaire to Assess Health-Enhancing Physical Activity at baseline, 13 weeks, 26 weeks, and 52 weeks after start of treatment in the context of the Combinatietherapie Bij Reumatoïde Artritis-Light trial. The reported PA classified patients as meeting or not meeting the World Health Organization (WHO) PA guideline (cutoff: 150 minutes of moderate-to-intense activity per week). Other measurements included the Disease Activity Score (DAS). Since both treatment arms showed equal treatment effect, these were analyzed as 1 group with simple before-after analyses and generalized estimating equations (GEE).

RESULTS: In these analyses, 140 patients (86% of the trial population, 66% women, mean age 52 years) with complete data were included. At entry, 69% of the patients met the WHO PA guideline, increasing to 90% at week 13, and remaining stable at 89% after 1 year (P < 0.001). Mean DAS improved from 4.0 to 1.8 during the first year of treatment (P < 0.001). In GEE analyses, DAS decreases were significantly associated with PA increases (P = 0.008). Patients with clinically relevant responses (expressed as DAS remission, European League Against Rheumatism good response or American College of Rheumatology criteria for 70% improvement response) showed higher PA levels compared to nonresponders, regardless of the definition of response, for both the WHO and Dutch PA guideline.

CONCLUSION: Early rheumatoid arthritis patients using combination therapy improved both disease activity and PA, a beneficial effect persisting for at least 1 year.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalArthritis Care & Research
Volume68
Issue number2
DOIs
Publication statusPublished - Feb 2016

Cite this

@article{3e7514be636148a794d77f0efd1c24a8,
title = "Effective Treatment for Rapid Improvement of Both Disease Activity and Self-Reported Physical Activity in Early Rheumatoid Arthritis",
abstract = "OBJECTIVE: To investigate the longitudinal relationship between disease activity and self-reported physical activity (PA) in patients with early rheumatoid arthritis during the first year of treatment with combination therapy.METHODS: PA was measured with the Short Questionnaire to Assess Health-Enhancing Physical Activity at baseline, 13 weeks, 26 weeks, and 52 weeks after start of treatment in the context of the Combinatietherapie Bij Reumato{\"i}de Artritis-Light trial. The reported PA classified patients as meeting or not meeting the World Health Organization (WHO) PA guideline (cutoff: 150 minutes of moderate-to-intense activity per week). Other measurements included the Disease Activity Score (DAS). Since both treatment arms showed equal treatment effect, these were analyzed as 1 group with simple before-after analyses and generalized estimating equations (GEE).RESULTS: In these analyses, 140 patients (86{\%} of the trial population, 66{\%} women, mean age 52 years) with complete data were included. At entry, 69{\%} of the patients met the WHO PA guideline, increasing to 90{\%} at week 13, and remaining stable at 89{\%} after 1 year (P < 0.001). Mean DAS improved from 4.0 to 1.8 during the first year of treatment (P < 0.001). In GEE analyses, DAS decreases were significantly associated with PA increases (P = 0.008). Patients with clinically relevant responses (expressed as DAS remission, European League Against Rheumatism good response or American College of Rheumatology criteria for 70{\%} improvement response) showed higher PA levels compared to nonresponders, regardless of the definition of response, for both the WHO and Dutch PA guideline.CONCLUSION: Early rheumatoid arthritis patients using combination therapy improved both disease activity and PA, a beneficial effect persisting for at least 1 year.",
keywords = "Adult, Aged, Aged, 80 and over, Antirheumatic Agents/therapeutic use, Arthritis, Rheumatoid/therapy, Combined Modality Therapy, Exercise, Female, Humans, Male, Middle Aged, Phototherapy, Self Report, Young Adult",
author = "Konijn, {Nicole P. C.} and {van Tuyl}, {Lilian H. D.} and Maarten Boers and {den Uyl}, Debby and {ter Wee}, {Marieke M.} and Pit Kerstens and AE Voskuyl and Michael Nurmohamed and {van Schaardenburg}, Dirkjan and Lems, {Willem F.}",
note = "{\circledC} 2016, American College of Rheumatology.",
year = "2016",
month = "2",
doi = "10.1002/acr.22668",
language = "English",
volume = "68",
pages = "280--284",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

Effective Treatment for Rapid Improvement of Both Disease Activity and Self-Reported Physical Activity in Early Rheumatoid Arthritis. / Konijn, Nicole P. C.; van Tuyl, Lilian H. D.; Boers, Maarten; den Uyl, Debby; ter Wee, Marieke M.; Kerstens, Pit; Voskuyl, AE; Nurmohamed, Michael; van Schaardenburg, Dirkjan; Lems, Willem F.

In: Arthritis Care & Research, Vol. 68, No. 2, 02.2016, p. 280-284.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effective Treatment for Rapid Improvement of Both Disease Activity and Self-Reported Physical Activity in Early Rheumatoid Arthritis

AU - Konijn, Nicole P. C.

AU - van Tuyl, Lilian H. D.

AU - Boers, Maarten

AU - den Uyl, Debby

AU - ter Wee, Marieke M.

AU - Kerstens, Pit

AU - Voskuyl, AE

AU - Nurmohamed, Michael

AU - van Schaardenburg, Dirkjan

AU - Lems, Willem F.

N1 - © 2016, American College of Rheumatology.

PY - 2016/2

Y1 - 2016/2

N2 - OBJECTIVE: To investigate the longitudinal relationship between disease activity and self-reported physical activity (PA) in patients with early rheumatoid arthritis during the first year of treatment with combination therapy.METHODS: PA was measured with the Short Questionnaire to Assess Health-Enhancing Physical Activity at baseline, 13 weeks, 26 weeks, and 52 weeks after start of treatment in the context of the Combinatietherapie Bij Reumatoïde Artritis-Light trial. The reported PA classified patients as meeting or not meeting the World Health Organization (WHO) PA guideline (cutoff: 150 minutes of moderate-to-intense activity per week). Other measurements included the Disease Activity Score (DAS). Since both treatment arms showed equal treatment effect, these were analyzed as 1 group with simple before-after analyses and generalized estimating equations (GEE).RESULTS: In these analyses, 140 patients (86% of the trial population, 66% women, mean age 52 years) with complete data were included. At entry, 69% of the patients met the WHO PA guideline, increasing to 90% at week 13, and remaining stable at 89% after 1 year (P < 0.001). Mean DAS improved from 4.0 to 1.8 during the first year of treatment (P < 0.001). In GEE analyses, DAS decreases were significantly associated with PA increases (P = 0.008). Patients with clinically relevant responses (expressed as DAS remission, European League Against Rheumatism good response or American College of Rheumatology criteria for 70% improvement response) showed higher PA levels compared to nonresponders, regardless of the definition of response, for both the WHO and Dutch PA guideline.CONCLUSION: Early rheumatoid arthritis patients using combination therapy improved both disease activity and PA, a beneficial effect persisting for at least 1 year.

AB - OBJECTIVE: To investigate the longitudinal relationship between disease activity and self-reported physical activity (PA) in patients with early rheumatoid arthritis during the first year of treatment with combination therapy.METHODS: PA was measured with the Short Questionnaire to Assess Health-Enhancing Physical Activity at baseline, 13 weeks, 26 weeks, and 52 weeks after start of treatment in the context of the Combinatietherapie Bij Reumatoïde Artritis-Light trial. The reported PA classified patients as meeting or not meeting the World Health Organization (WHO) PA guideline (cutoff: 150 minutes of moderate-to-intense activity per week). Other measurements included the Disease Activity Score (DAS). Since both treatment arms showed equal treatment effect, these were analyzed as 1 group with simple before-after analyses and generalized estimating equations (GEE).RESULTS: In these analyses, 140 patients (86% of the trial population, 66% women, mean age 52 years) with complete data were included. At entry, 69% of the patients met the WHO PA guideline, increasing to 90% at week 13, and remaining stable at 89% after 1 year (P < 0.001). Mean DAS improved from 4.0 to 1.8 during the first year of treatment (P < 0.001). In GEE analyses, DAS decreases were significantly associated with PA increases (P = 0.008). Patients with clinically relevant responses (expressed as DAS remission, European League Against Rheumatism good response or American College of Rheumatology criteria for 70% improvement response) showed higher PA levels compared to nonresponders, regardless of the definition of response, for both the WHO and Dutch PA guideline.CONCLUSION: Early rheumatoid arthritis patients using combination therapy improved both disease activity and PA, a beneficial effect persisting for at least 1 year.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antirheumatic Agents/therapeutic use

KW - Arthritis, Rheumatoid/therapy

KW - Combined Modality Therapy

KW - Exercise

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Phototherapy

KW - Self Report

KW - Young Adult

U2 - 10.1002/acr.22668

DO - 10.1002/acr.22668

M3 - Article

VL - 68

SP - 280

EP - 284

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 2

ER -