Effectiviteit van een gestandaardiseerd oraal vitamine D-doseringsregime bij somatische en psychogeriatrische verpleeghuisbewoners

Translated title of the contribution: Effectiveness of a standardised oral Vitamin D dosing regimen for somatic and psychogeriatric nursing home residents

M. L. Toren-Wielema*, R. B. Veenhuizen, J. W. Kappelle, N. J.G.M. Veeger, E. N. Van Roon

*Corresponding author for this work

Research output: Contribution to journalArticleProfessional

Abstract

BACKGROUND The prevalence of Vitamin D deficiency in nursing home residents (NHR) ranges from 79 to 98%. OBJECTIVE To determine the efficacy of a standardised oral Vitamin D dosing regimen (VDDRI consisting of a loading dose (ID) of 200,000 IU followed by a maintenance dose (MD) of 100.000 IU every 13 weeks in obtaining and maintaining an adequate and safe serum Vitamin D trough level (VDTL) in somatic and psychogeriatric NHR. DESIGN Cross-sectional observational study. METHODS Blood samples of NHR who had received the LD followed by at least one MD were analysed for VDTL. calcium, parathyroid hormone and creatinine. Data on age. sex. race, body weight, length, co-morbidity, co-medication, number of MDS. calcium supplementation, smoking and use of alcohol were obtained from patient charts. The primary outcome for the efficacy of the VDDR was defined as the percentage of NHR with a VDTL 75-220 nmol/L. A percentage of 75.31% was considered to be non-inferior to the aimed percentage of 85% la 0.05; p 0.0881). Secondary outcomes were analysed as dichotomous variables using binary logistic regression. RESULTS In 91 of 156 included NHR (58%) a VDTL of 75-220 nmol/L was measured (average 81, standard deviation 28, range 13-150). Data were abstracted from the charts of 138 NHR (88%). The only variable found to be a significant predictor for obtaining a VDTL i 75 nmol/L was a larger number of MDS Ut 4 versus < A; odds ratio 2.69; 95% confidence interval 1.36-5.33). CONCLUSION The VDDR was not efficacious in obtaining and maintaining an adequate VDTL in NHR.

Translated title of the contributionEffectiveness of a standardised oral Vitamin D dosing regimen for somatic and psychogeriatric nursing home residents
Original languageFrench
Pages (from-to)27-31
Number of pages5
JournalPharmaceutisch Weekblad
Volume152
Issue number37
Publication statusPublished - 15 Sep 2017

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