Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

P. Bernard, J. Savard, K. Steindorf, M. G. Sweegers, K. S. Courneya, R. U. Newton, N. K. Aaronson, P. B. Jacobsen, A. M. May, D. A. Galvao, M. J. Chinapaw, M. M. Stuiver, K. A. Griffith, I. Mesters, H. Knoop, M. M. Goedendorp, M. Bohus, L. Thorsen, M. E. Schmidt, C. M. Ulrich & 13 others G. S. Sonke, W. van Harten, K. M. Winters-Stone, M. J. Velthuis, D. R. Taaffe, W. van Mechelen, M. J. Kersten, F. Nollet, J. Wenzel, J. Wiskemann, I. M. Verdonck-de Leeuw, J. Brug, L. M. Buffart

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Objectives: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. Methods: Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age = 54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics. Results: For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g = −0.09, 95% CI [−0.16; −0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances. Conclusions: This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.
Original languageEnglish
Article number109746
JournalJournal of Psychosomatic Research
Volume124
DOIs
Publication statusPublished - 1 Sep 2019

Cite this

Bernard, P. ; Savard, J. ; Steindorf, K. ; Sweegers, M. G. ; Courneya, K. S. ; Newton, R. U. ; Aaronson, N. K. ; Jacobsen, P. B. ; May, A. M. ; Galvao, D. A. ; Chinapaw, M. J. ; Stuiver, M. M. ; Griffith, K. A. ; Mesters, I. ; Knoop, H. ; Goedendorp, M. M. ; Bohus, M. ; Thorsen, L. ; Schmidt, M. E. ; Ulrich, C. M. ; Sonke, G. S. ; van Harten, W. ; Winters-Stone, K. M. ; Velthuis, M. J. ; Taaffe, D. R. ; van Mechelen, W. ; Kersten, M. J. ; Nollet, F. ; Wenzel, J. ; Wiskemann, J. ; Verdonck-de Leeuw, I. M. ; Brug, J. ; Buffart, L. M. / Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses. In: Journal of Psychosomatic Research. 2019 ; Vol. 124.
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title = "Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses",
abstract = "Objectives: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. Methods: Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age = 54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics. Results: For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g = −0.09, 95{\%} CI [−0.16; −0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances. Conclusions: This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.",
author = "P. Bernard and J. Savard and K. Steindorf and Sweegers, {M. G.} and Courneya, {K. S.} and Newton, {R. U.} and Aaronson, {N. K.} and Jacobsen, {P. B.} and May, {A. M.} and Galvao, {D. A.} and Chinapaw, {M. J.} and Stuiver, {M. M.} and Griffith, {K. A.} and I. Mesters and H. Knoop and Goedendorp, {M. M.} and M. Bohus and L. Thorsen and Schmidt, {M. E.} and Ulrich, {C. M.} and Sonke, {G. S.} and {van Harten}, W. and Winters-Stone, {K. M.} and Velthuis, {M. J.} and Taaffe, {D. R.} and {van Mechelen}, W. and Kersten, {M. J.} and F. Nollet and J. Wenzel and J. Wiskemann and {Verdonck-de Leeuw}, {I. M.} and J. Brug and Buffart, {L. M.}",
year = "2019",
month = "9",
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doi = "10.1016/j.jpsychores.2019.109746",
language = "English",
volume = "124",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier Inc.",

}

Bernard, P, Savard, J, Steindorf, K, Sweegers, MG, Courneya, KS, Newton, RU, Aaronson, NK, Jacobsen, PB, May, AM, Galvao, DA, Chinapaw, MJ, Stuiver, MM, Griffith, KA, Mesters, I, Knoop, H, Goedendorp, MM, Bohus, M, Thorsen, L, Schmidt, ME, Ulrich, CM, Sonke, GS, van Harten, W, Winters-Stone, KM, Velthuis, MJ, Taaffe, DR, van Mechelen, W, Kersten, MJ, Nollet, F, Wenzel, J, Wiskemann, J, Verdonck-de Leeuw, IM, Brug, J & Buffart, LM 2019, 'Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses' Journal of Psychosomatic Research, vol. 124, 109746. https://doi.org/10.1016/j.jpsychores.2019.109746

Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses. / Bernard, P.; Savard, J.; Steindorf, K.; Sweegers, M. G.; Courneya, K. S.; Newton, R. U.; Aaronson, N. K.; Jacobsen, P. B.; May, A. M.; Galvao, D. A.; Chinapaw, M. J.; Stuiver, M. M.; Griffith, K. A.; Mesters, I.; Knoop, H.; Goedendorp, M. M.; Bohus, M.; Thorsen, L.; Schmidt, M. E.; Ulrich, C. M.; Sonke, G. S.; van Harten, W.; Winters-Stone, K. M.; Velthuis, M. J.; Taaffe, D. R.; van Mechelen, W.; Kersten, M. J.; Nollet, F.; Wenzel, J.; Wiskemann, J.; Verdonck-de Leeuw, I. M.; Brug, J.; Buffart, L. M.

In: Journal of Psychosomatic Research, Vol. 124, 109746, 01.09.2019.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses

AU - Bernard, P.

AU - Savard, J.

AU - Steindorf, K.

AU - Sweegers, M. G.

AU - Courneya, K. S.

AU - Newton, R. U.

AU - Aaronson, N. K.

AU - Jacobsen, P. B.

AU - May, A. M.

AU - Galvao, D. A.

AU - Chinapaw, M. J.

AU - Stuiver, M. M.

AU - Griffith, K. A.

AU - Mesters, I.

AU - Knoop, H.

AU - Goedendorp, M. M.

AU - Bohus, M.

AU - Thorsen, L.

AU - Schmidt, M. E.

AU - Ulrich, C. M.

AU - Sonke, G. S.

AU - van Harten, W.

AU - Winters-Stone, K. M.

AU - Velthuis, M. J.

AU - Taaffe, D. R.

AU - van Mechelen, W.

AU - Kersten, M. J.

AU - Nollet, F.

AU - Wenzel, J.

AU - Wiskemann, J.

AU - Verdonck-de Leeuw, I. M.

AU - Brug, J.

AU - Buffart, L. M.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objectives: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. Methods: Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age = 54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics. Results: For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g = −0.09, 95% CI [−0.16; −0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances. Conclusions: This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.

AB - Objectives: To evaluate the effects of exercise interventions on sleep disturbances and sleep quality in patients with mixed cancer diagnoses, and identify demographic, clinical, and intervention-related moderators of these effects. Methods: Individual patient data (IPD) and aggregated meta-analyses of randomized controlled trials (RCTs). Using data from the Predicting OptimaL cAncer RehabIlitation and Supportive care project, IPD of 2173 adults (mean age = 54.8) with cancer from 17 RCTs were analyzed. A complementary systematic search was conducted (until November 2018) to study the overall effects and test the representativeness of analyzed IPD. Effect sizes of exercise effects on self-reported sleep outcomes were calculated for all included RCTs. Linear mixed-effect models were used to evaluate the effects of exercise on post-intervention outcome values, adjusting for baseline values. Moderator effects were studied by testing interactions for demographic, clinical and intervention-related characteristics. Results: For all 27 eligible RCTs from the updated search, exercise interventions significantly decreased sleep disturbances in adults with cancer (g = −0.09, 95% CI [−0.16; −0.02]). No significant effect was obtained for sleep quality. RCTs included in IPD analyses constituted a representative sample of the published literature. The intervention effects on sleep disturbances were not significantly moderated by any demographic, clinical, or intervention-related factor, nor by sleep disturbances. Conclusions: This meta-analysis provides some evidence that, compared to control conditions, exercise interventions may improve sleep disturbances, but not sleep quality, in cancer patients, although this effect is of a small magnitude. Among the investigated variables, none was found to significantly moderate the effect of exercise interventions on sleep disturbances.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/31443811

U2 - 10.1016/j.jpsychores.2019.109746

DO - 10.1016/j.jpsychores.2019.109746

M3 - Review article

VL - 124

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

M1 - 109746

ER -