Effects of a Multidisciplinary Intervention on the Presence of Neuropsychiatric Symptoms and Psychotropic Drug Use in Nursing Home Residents WithYoung-Onset Dementia: Behavior and Evolution of Young-Onset Dementia Part 2 (BEYOND-II) Study

Britt Appelhof, Christian Bakker, Marjolein E. de Vugt, Jeannette C. L. van Duinen-van den IJssel, Sandra A. Zwijsen, Martin Smalbrugge, Steven Teerenstra, Frans R. J. Verhey, Sytse U. Zuidema, Raymond T. C. M. Koopmans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: The effect of an intervention on neuropsychiatric symptoms (NPS), particularly agitation and aggression, and psychotropic drug use (PDU) in institutionalized people with young-onset dementia (YOD) was evaluated. Methods: A randomized controlled trial was conducted using a stepped wedge design. Thirteen YOD special care units were randomly assigned to three groups, which received the intervention at different time points. Four assessments took place every 6 months during a period of 18 months. Two hundred seventy-four people with YOD who resided in YOD special care units participated, of whom 131 took part in all assessments. The intervention consisted of an educational program combined with a care program, which structured the multidisciplinary process of managing NPS. The care program included the following five steps: evaluation of psychotropic drug prescription, detection, analysis, treatment, and evaluation of treatment of NPS. The Cohen-Mansfield Agitation Inventory and the Neuropsychiatric Inventory-Nursing Home version were used to assess NPS. Data on PDU were retrieved from residents’ medical files. Multilevel models were used to evaluate the effect of the intervention, which accounted for clustering of measurements in clients within units. Results: No significant differences were found in agitation, aggression, other NPS, or PDU after crossing over to the intervention condition. Conclusion: We found no evidence that the intervention for management of NPS in nursing home residents with YOD was more effective in reducing agitation, aggression, other NPS, or PDU compared with care as usual.
Original languageEnglish
JournalAmerican Journal of Geriatric Psychiatry
DOIs
Publication statusPublished - 2019

Cite this

@article{f9191e1573904ffa976290259857c714,
title = "Effects of a Multidisciplinary Intervention on the Presence of Neuropsychiatric Symptoms and Psychotropic Drug Use in Nursing Home Residents WithYoung-Onset Dementia: Behavior and Evolution of Young-Onset Dementia Part 2 (BEYOND-II) Study",
abstract = "Objective: The effect of an intervention on neuropsychiatric symptoms (NPS), particularly agitation and aggression, and psychotropic drug use (PDU) in institutionalized people with young-onset dementia (YOD) was evaluated. Methods: A randomized controlled trial was conducted using a stepped wedge design. Thirteen YOD special care units were randomly assigned to three groups, which received the intervention at different time points. Four assessments took place every 6 months during a period of 18 months. Two hundred seventy-four people with YOD who resided in YOD special care units participated, of whom 131 took part in all assessments. The intervention consisted of an educational program combined with a care program, which structured the multidisciplinary process of managing NPS. The care program included the following five steps: evaluation of psychotropic drug prescription, detection, analysis, treatment, and evaluation of treatment of NPS. The Cohen-Mansfield Agitation Inventory and the Neuropsychiatric Inventory-Nursing Home version were used to assess NPS. Data on PDU were retrieved from residents’ medical files. Multilevel models were used to evaluate the effect of the intervention, which accounted for clustering of measurements in clients within units. Results: No significant differences were found in agitation, aggression, other NPS, or PDU after crossing over to the intervention condition. Conclusion: We found no evidence that the intervention for management of NPS in nursing home residents with YOD was more effective in reducing agitation, aggression, other NPS, or PDU compared with care as usual.",
author = "Britt Appelhof and Christian Bakker and {de Vugt}, {Marjolein E.} and {van Duinen-van den IJssel}, {Jeannette C. L.} and Zwijsen, {Sandra A.} and Martin Smalbrugge and Steven Teerenstra and Verhey, {Frans R. J.} and Zuidema, {Sytse U.} and Koopmans, {Raymond T. C. M.}",
year = "2019",
doi = "10.1016/j.jagp.2018.12.032",
language = "English",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Lippincott Williams and Wilkins",

}

Effects of a Multidisciplinary Intervention on the Presence of Neuropsychiatric Symptoms and Psychotropic Drug Use in Nursing Home Residents WithYoung-Onset Dementia: Behavior and Evolution of Young-Onset Dementia Part 2 (BEYOND-II) Study. / Appelhof, Britt; Bakker, Christian; de Vugt, Marjolein E.; van Duinen-van den IJssel, Jeannette C. L.; Zwijsen, Sandra A.; Smalbrugge, Martin; Teerenstra, Steven; Verhey, Frans R. J.; Zuidema, Sytse U.; Koopmans, Raymond T. C. M.

In: American Journal of Geriatric Psychiatry, 2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of a Multidisciplinary Intervention on the Presence of Neuropsychiatric Symptoms and Psychotropic Drug Use in Nursing Home Residents WithYoung-Onset Dementia: Behavior and Evolution of Young-Onset Dementia Part 2 (BEYOND-II) Study

AU - Appelhof, Britt

AU - Bakker, Christian

AU - de Vugt, Marjolein E.

AU - van Duinen-van den IJssel, Jeannette C. L.

AU - Zwijsen, Sandra A.

AU - Smalbrugge, Martin

AU - Teerenstra, Steven

AU - Verhey, Frans R. J.

AU - Zuidema, Sytse U.

AU - Koopmans, Raymond T. C. M.

PY - 2019

Y1 - 2019

N2 - Objective: The effect of an intervention on neuropsychiatric symptoms (NPS), particularly agitation and aggression, and psychotropic drug use (PDU) in institutionalized people with young-onset dementia (YOD) was evaluated. Methods: A randomized controlled trial was conducted using a stepped wedge design. Thirteen YOD special care units were randomly assigned to three groups, which received the intervention at different time points. Four assessments took place every 6 months during a period of 18 months. Two hundred seventy-four people with YOD who resided in YOD special care units participated, of whom 131 took part in all assessments. The intervention consisted of an educational program combined with a care program, which structured the multidisciplinary process of managing NPS. The care program included the following five steps: evaluation of psychotropic drug prescription, detection, analysis, treatment, and evaluation of treatment of NPS. The Cohen-Mansfield Agitation Inventory and the Neuropsychiatric Inventory-Nursing Home version were used to assess NPS. Data on PDU were retrieved from residents’ medical files. Multilevel models were used to evaluate the effect of the intervention, which accounted for clustering of measurements in clients within units. Results: No significant differences were found in agitation, aggression, other NPS, or PDU after crossing over to the intervention condition. Conclusion: We found no evidence that the intervention for management of NPS in nursing home residents with YOD was more effective in reducing agitation, aggression, other NPS, or PDU compared with care as usual.

AB - Objective: The effect of an intervention on neuropsychiatric symptoms (NPS), particularly agitation and aggression, and psychotropic drug use (PDU) in institutionalized people with young-onset dementia (YOD) was evaluated. Methods: A randomized controlled trial was conducted using a stepped wedge design. Thirteen YOD special care units were randomly assigned to three groups, which received the intervention at different time points. Four assessments took place every 6 months during a period of 18 months. Two hundred seventy-four people with YOD who resided in YOD special care units participated, of whom 131 took part in all assessments. The intervention consisted of an educational program combined with a care program, which structured the multidisciplinary process of managing NPS. The care program included the following five steps: evaluation of psychotropic drug prescription, detection, analysis, treatment, and evaluation of treatment of NPS. The Cohen-Mansfield Agitation Inventory and the Neuropsychiatric Inventory-Nursing Home version were used to assess NPS. Data on PDU were retrieved from residents’ medical files. Multilevel models were used to evaluate the effect of the intervention, which accounted for clustering of measurements in clients within units. Results: No significant differences were found in agitation, aggression, other NPS, or PDU after crossing over to the intervention condition. Conclusion: We found no evidence that the intervention for management of NPS in nursing home residents with YOD was more effective in reducing agitation, aggression, other NPS, or PDU compared with care as usual.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061801057&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30799167

U2 - 10.1016/j.jagp.2018.12.032

DO - 10.1016/j.jagp.2018.12.032

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JO - American Journal of Geriatric Psychiatry

JF - American Journal of Geriatric Psychiatry

SN - 1064-7481

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