Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; A secondary analysis of a randomized controlled trial

Tessa M. van Elteni, Matty D. A. Karsten, Anouk Geelen, Anne M. van Oers, Mireille N. M. van Poppel, Henk Groen, Reinoud J. B. J. Gemke, Ben Willem Mol, Meike A. Q. Mutsaerts, Tessa J. Roseboom, Annemieke Hoek

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background Lifestyle changes are notoriously difficult. Since women who intend to become pregnant are more susceptible to lifestyle advice, interventions during this time window might be more effective than interventions during any other period in life. We here report the effects of the first large preconception lifestyle intervention RCT on diet and physical activity in obese infertile women. Methods In total, 577 women were randomized between a six-month lifestyle intervention program (intervention group; N = 290) or prompt infertility treatment (control group; N = 287). Self-reported dietary behaviors and physical activity were assessed at baseline, three, six and twelve months after randomization. Mixed models were used to analyze differences between groups. Results Compared to the control group, the intervention group reduced their intake of sugary drinks at three months (-0.5 glasses/day [95% C.I. = -0.9;-0.2]), of savory snacks at three (-2.4 handful/week [-3.4;-1.4]) and at six months (-1.4 handful/week [-2.6;-0.2]), and of sweet snacks at three (-2.2 portion/week [-3.3;-1.0]) and twelve months after randomization (-1.9 portion/week [-3.5;-0.4]). Also, the intervention group was more moderate to vigorous physically active at three months after randomization compared to the control group (169.0 minutes/ week [6.0; 332.1]). Conclusion Our study showed that obese infertile women who followed a six-month preconception lifestyle intervention program decreased their intake of high caloric snacks and beverages, and increased their physical activity. These changes in lifestyle may not only improve women's health but their offspring's health too.
Original languageEnglish
Article numbere0206888
JournalPLoS ONE
Volume13
Issue number11
DOIs
Publication statusPublished - 2018

Cite this

van Elteni, Tessa M. ; Karsten, Matty D. A. ; Geelen, Anouk ; van Oers, Anne M. ; van Poppel, Mireille N. M. ; Groen, Henk ; Gemke, Reinoud J. B. J. ; Mol, Ben Willem ; Mutsaerts, Meike A. Q. ; Roseboom, Tessa J. ; Hoek, Annemieke. / Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; A secondary analysis of a randomized controlled trial. In: PLoS ONE. 2018 ; Vol. 13, No. 11.
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title = "Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; A secondary analysis of a randomized controlled trial",
abstract = "Background Lifestyle changes are notoriously difficult. Since women who intend to become pregnant are more susceptible to lifestyle advice, interventions during this time window might be more effective than interventions during any other period in life. We here report the effects of the first large preconception lifestyle intervention RCT on diet and physical activity in obese infertile women. Methods In total, 577 women were randomized between a six-month lifestyle intervention program (intervention group; N = 290) or prompt infertility treatment (control group; N = 287). Self-reported dietary behaviors and physical activity were assessed at baseline, three, six and twelve months after randomization. Mixed models were used to analyze differences between groups. Results Compared to the control group, the intervention group reduced their intake of sugary drinks at three months (-0.5 glasses/day [95{\%} C.I. = -0.9;-0.2]), of savory snacks at three (-2.4 handful/week [-3.4;-1.4]) and at six months (-1.4 handful/week [-2.6;-0.2]), and of sweet snacks at three (-2.2 portion/week [-3.3;-1.0]) and twelve months after randomization (-1.9 portion/week [-3.5;-0.4]). Also, the intervention group was more moderate to vigorous physically active at three months after randomization compared to the control group (169.0 minutes/ week [6.0; 332.1]). Conclusion Our study showed that obese infertile women who followed a six-month preconception lifestyle intervention program decreased their intake of high caloric snacks and beverages, and increased their physical activity. These changes in lifestyle may not only improve women's health but their offspring's health too.",
author = "{van Elteni}, {Tessa M.} and Karsten, {Matty D. A.} and Anouk Geelen and {van Oers}, {Anne M.} and {van Poppel}, {Mireille N. M.} and Henk Groen and Gemke, {Reinoud J. B. J.} and Mol, {Ben Willem} and Mutsaerts, {Meike A. Q.} and Roseboom, {Tessa J.} and Annemieke Hoek",
year = "2018",
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language = "English",
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Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; A secondary analysis of a randomized controlled trial. / van Elteni, Tessa M.; Karsten, Matty D. A.; Geelen, Anouk; van Oers, Anne M.; van Poppel, Mireille N. M.; Groen, Henk; Gemke, Reinoud J. B. J.; Mol, Ben Willem; Mutsaerts, Meike A. Q.; Roseboom, Tessa J.; Hoek, Annemieke.

In: PLoS ONE, Vol. 13, No. 11, e0206888, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; A secondary analysis of a randomized controlled trial

AU - van Elteni, Tessa M.

AU - Karsten, Matty D. A.

AU - Geelen, Anouk

AU - van Oers, Anne M.

AU - van Poppel, Mireille N. M.

AU - Groen, Henk

AU - Gemke, Reinoud J. B. J.

AU - Mol, Ben Willem

AU - Mutsaerts, Meike A. Q.

AU - Roseboom, Tessa J.

AU - Hoek, Annemieke

PY - 2018

Y1 - 2018

N2 - Background Lifestyle changes are notoriously difficult. Since women who intend to become pregnant are more susceptible to lifestyle advice, interventions during this time window might be more effective than interventions during any other period in life. We here report the effects of the first large preconception lifestyle intervention RCT on diet and physical activity in obese infertile women. Methods In total, 577 women were randomized between a six-month lifestyle intervention program (intervention group; N = 290) or prompt infertility treatment (control group; N = 287). Self-reported dietary behaviors and physical activity were assessed at baseline, three, six and twelve months after randomization. Mixed models were used to analyze differences between groups. Results Compared to the control group, the intervention group reduced their intake of sugary drinks at three months (-0.5 glasses/day [95% C.I. = -0.9;-0.2]), of savory snacks at three (-2.4 handful/week [-3.4;-1.4]) and at six months (-1.4 handful/week [-2.6;-0.2]), and of sweet snacks at three (-2.2 portion/week [-3.3;-1.0]) and twelve months after randomization (-1.9 portion/week [-3.5;-0.4]). Also, the intervention group was more moderate to vigorous physically active at three months after randomization compared to the control group (169.0 minutes/ week [6.0; 332.1]). Conclusion Our study showed that obese infertile women who followed a six-month preconception lifestyle intervention program decreased their intake of high caloric snacks and beverages, and increased their physical activity. These changes in lifestyle may not only improve women's health but their offspring's health too.

AB - Background Lifestyle changes are notoriously difficult. Since women who intend to become pregnant are more susceptible to lifestyle advice, interventions during this time window might be more effective than interventions during any other period in life. We here report the effects of the first large preconception lifestyle intervention RCT on diet and physical activity in obese infertile women. Methods In total, 577 women were randomized between a six-month lifestyle intervention program (intervention group; N = 290) or prompt infertility treatment (control group; N = 287). Self-reported dietary behaviors and physical activity were assessed at baseline, three, six and twelve months after randomization. Mixed models were used to analyze differences between groups. Results Compared to the control group, the intervention group reduced their intake of sugary drinks at three months (-0.5 glasses/day [95% C.I. = -0.9;-0.2]), of savory snacks at three (-2.4 handful/week [-3.4;-1.4]) and at six months (-1.4 handful/week [-2.6;-0.2]), and of sweet snacks at three (-2.2 portion/week [-3.3;-1.0]) and twelve months after randomization (-1.9 portion/week [-3.5;-0.4]). Also, the intervention group was more moderate to vigorous physically active at three months after randomization compared to the control group (169.0 minutes/ week [6.0; 332.1]). Conclusion Our study showed that obese infertile women who followed a six-month preconception lifestyle intervention program decreased their intake of high caloric snacks and beverages, and increased their physical activity. These changes in lifestyle may not only improve women's health but their offspring's health too.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30403756

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DO - 10.1371/journal.pone.0206888

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