Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans

Linda Yi-Chieh Poon, Hussein Antar, Edem Tsikata, Rong Guo, Georgia Papadogeorgou, Madeline Freeman, Ziad Khoueir, Ramon Lee, Eric Shieh, Huseyin Simavli, Christian John Que, Johannes F. de Boer, Teresa C. Chen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area. Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3%, 2.0%, 1.7%, 3.3%, and 4.3% per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity. Conclusions: All of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. Translational Relevance: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.
LanguageEnglish
Article number12
JournalTranslational Vision Science and Technology
Volume7
Issue number6
DOIs
Publication statusPublished - 2018

Cite this

Poon, Linda Yi-Chieh ; Antar, Hussein ; Tsikata, Edem ; Guo, Rong ; Papadogeorgou, Georgia ; Freeman, Madeline ; Khoueir, Ziad ; Lee, Ramon ; Shieh, Eric ; Simavli, Huseyin ; Que, Christian John ; de Boer, Johannes F. ; Chen, Teresa C. / Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans. In: Translational Vision Science and Technology. 2018 ; Vol. 7, No. 6.
@article{a318b31cc26f43dda5f7a600ee9805b0,
title = "Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans",
abstract = "Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area. Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3{\%}, 2.0{\%}, 1.7{\%}, 3.3{\%}, and 4.3{\%} per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity. Conclusions: All of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. Translational Relevance: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.",
author = "Poon, {Linda Yi-Chieh} and Hussein Antar and Edem Tsikata and Rong Guo and Georgia Papadogeorgou and Madeline Freeman and Ziad Khoueir and Ramon Lee and Eric Shieh and Huseyin Simavli and Que, {Christian John} and {de Boer}, {Johannes F.} and Chen, {Teresa C.}",
year = "2018",
doi = "10.1167/tvst.7.6.12",
language = "English",
volume = "7",
journal = "Translational Vision Science and Technology",
issn = "2164-2591",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "6",

}

Poon, LY-C, Antar, H, Tsikata, E, Guo, R, Papadogeorgou, G, Freeman, M, Khoueir, Z, Lee, R, Shieh, E, Simavli, H, Que, CJ, de Boer, JF & Chen, TC 2018, 'Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans', Translational Vision Science and Technology, vol. 7, no. 6, 12. https://doi.org/10.1167/tvst.7.6.12

Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans. / Poon, Linda Yi-Chieh; Antar, Hussein; Tsikata, Edem; Guo, Rong; Papadogeorgou, Georgia; Freeman, Madeline; Khoueir, Ziad; Lee, Ramon; Shieh, Eric; Simavli, Huseyin; Que, Christian John; de Boer, Johannes F.; Chen, Teresa C.

In: Translational Vision Science and Technology, Vol. 7, No. 6, 12, 2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of age, race, and ethnicity on the optic nerve and peripapillary region using spectral-domain OCT 3d volume scans

AU - Poon, Linda Yi-Chieh

AU - Antar, Hussein

AU - Tsikata, Edem

AU - Guo, Rong

AU - Papadogeorgou, Georgia

AU - Freeman, Madeline

AU - Khoueir, Ziad

AU - Lee, Ramon

AU - Shieh, Eric

AU - Simavli, Huseyin

AU - Que, Christian John

AU - de Boer, Johannes F.

AU - Chen, Teresa C.

PY - 2018

Y1 - 2018

N2 - Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area. Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3%, 2.0%, 1.7%, 3.3%, and 4.3% per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity. Conclusions: All of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. Translational Relevance: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.

AB - Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects. Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area. Results: There were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3%, 2.0%, 1.7%, 3.3%, and 4.3% per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity. Conclusions: All of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. Translational Relevance: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059254410&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30510856

U2 - 10.1167/tvst.7.6.12

DO - 10.1167/tvst.7.6.12

M3 - Article

VL - 7

JO - Translational Vision Science and Technology

T2 - Translational Vision Science and Technology

JF - Translational Vision Science and Technology

SN - 2164-2591

IS - 6

M1 - 12

ER -