Effects of exercise training in patients with idiopathic pulmonary arterial hypertension

F.S. de Man, M.L. Handoko, H. Groepenhoff, A.J. van 't Hul, J. Abbink, R.J.H. Koppers, H.P. Grotjohan, J.W.R. Twisk, H.J. Bogaard, A. Boonstra, P.E. Postmus, N. Westerhof, W.J. van der Laarse, A. Vonk Noordegraaf

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We determined the physiological effects of exercise training on exercise capacity and quadriceps muscle function in patients with idiopathic pulmonary arterial hypertension (iPAH). In total, 19 clinically stable iPAH patients (New York Heart Association II-III) underwent a supervised exercise training programme for the duration of 12 weeks. Maximal capacity, endurance capacity and quadriceps function were assessed at baseline and after 12 weeks. In 12 patients, serial quadriceps muscle biopsies were obtained. 6-min walk distance and peak exercise capacity did not change after training. However, endurance capacity improved significantly after training, demonstrated by a shift of the anaerobic threshold to a higher workload (from 32 +/- 5 to 46 +/- 6 W; p=0.003) together with an increase in exercise endurance time (p
Original languageUndefined/Unknown
Pages (from-to)669-675
JournalEuropean Respiratory Journal
Issue number3
Publication statusPublished - 2009

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