Effects of exercise training in patients with idiopathic pulmonary arterial hypertension

F.S. de Man; M.L. Handoko; H. Groepenhoff; A.J. van 't Hul; J. Abbink; R.J.H. Koppers; H.P. Grotjohan; J.W.R. Twisk; H.J. Bogaard; A. Boonstra; P.E. Postmus; N. Westerhof; W.J. van der Laarse; A. Vonk Noordegraaf

doi:10.1183/09031936.00027909

Effects of exercise training in patients with idiopathic pulmonary arterial hypertension

F.S. de Man, M.L. Handoko, H. Groepenhoff, A.J. van 't Hul, J. Abbink, R.J.H. Koppers, H.P. Grotjohan, J.W.R. Twisk, H.J. Bogaard, A. Boonstra, P.E. Postmus, N. Westerhof, W.J. van der Laarse, A. Vonk Noordegraaf

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We determined the physiological effects of exercise training on exercise capacity and quadriceps muscle function in patients with idiopathic pulmonary arterial hypertension (iPAH). In total, 19 clinically stable iPAH patients (New York Heart Association II-III) underwent a supervised exercise training programme for the duration of 12 weeks. Maximal capacity, endurance capacity and quadriceps function were assessed at baseline and after 12 weeks. In 12 patients, serial quadriceps muscle biopsies were obtained. 6-min walk distance and peak exercise capacity did not change after training. However, endurance capacity improved significantly after training, demonstrated by a shift of the anaerobic threshold to a higher workload (from 32 +/- 5 to 46 +/- 6 W; p=0.003) together with an increase in exercise endurance time (p

Original language	Undefined/Unknown
Pages (from-to)	669-675
Journal	European Respiratory Journal
Volume	34
Issue number	3
DOIs	https://doi.org/10.1183/09031936.00027909
Publication status	Published - 2009

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10.1183/09031936.00027909

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de Man, F. S., Handoko, M. L., Groepenhoff, H., van 't Hul, A. J., Abbink, J., Koppers, R. J. H., Grotjohan, H. P., Twisk, J. W. R., Bogaard, H. J., Boonstra, A., Postmus, P. E., Westerhof, N., van der Laarse, W. J., & Vonk Noordegraaf, A. (2009). Effects of exercise training in patients with idiopathic pulmonary arterial hypertension. European Respiratory Journal, 34(3), 669-675. https://doi.org/10.1183/09031936.00027909

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title = "Effects of exercise training in patients with idiopathic pulmonary arterial hypertension",

abstract = "We determined the physiological effects of exercise training on exercise capacity and quadriceps muscle function in patients with idiopathic pulmonary arterial hypertension (iPAH). In total, 19 clinically stable iPAH patients (New York Heart Association II-III) underwent a supervised exercise training programme for the duration of 12 weeks. Maximal capacity, endurance capacity and quadriceps function were assessed at baseline and after 12 weeks. In 12 patients, serial quadriceps muscle biopsies were obtained. 6-min walk distance and peak exercise capacity did not change after training. However, endurance capacity improved significantly after training, demonstrated by a shift of the anaerobic threshold to a higher workload (from 32 +/- 5 to 46 +/- 6 W; p=0.003) together with an increase in exercise endurance time (p",

author = "{de Man}, F.S. and M.L. Handoko and H. Groepenhoff and {van 't Hul}, A.J. and J. Abbink and R.J.H. Koppers and H.P. Grotjohan and J.W.R. Twisk and H.J. Bogaard and A. Boonstra and P.E. Postmus and N. Westerhof and {van der Laarse}, W.J. and {Vonk Noordegraaf}, A.",

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de Man, FS , Handoko, ML, Groepenhoff, H, van 't Hul, AJ, Abbink, J, Koppers, RJH, Grotjohan, HP, Twisk, JWR , Bogaard, HJ , Boonstra, A, Postmus, PE, Westerhof, N, van der Laarse, WJ & Vonk Noordegraaf, A 2009, 'Effects of exercise training in patients with idiopathic pulmonary arterial hypertension', European Respiratory Journal, vol. 34, no. 3, pp. 669-675. https://doi.org/10.1183/09031936.00027909

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T1 - Effects of exercise training in patients with idiopathic pulmonary arterial hypertension

AU - de Man, F.S.

AU - Handoko, M.L.

AU - Groepenhoff, H.

AU - van 't Hul, A.J.

AU - Abbink, J.

AU - Koppers, R.J.H.

AU - Grotjohan, H.P.

AU - Twisk, J.W.R.

AU - Bogaard, H.J.

AU - Boonstra, A.

AU - Postmus, P.E.

AU - Westerhof, N.

AU - van der Laarse, W.J.

AU - Vonk Noordegraaf, A.

PY - 2009

Y1 - 2009

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AB - We determined the physiological effects of exercise training on exercise capacity and quadriceps muscle function in patients with idiopathic pulmonary arterial hypertension (iPAH). In total, 19 clinically stable iPAH patients (New York Heart Association II-III) underwent a supervised exercise training programme for the duration of 12 weeks. Maximal capacity, endurance capacity and quadriceps function were assessed at baseline and after 12 weeks. In 12 patients, serial quadriceps muscle biopsies were obtained. 6-min walk distance and peak exercise capacity did not change after training. However, endurance capacity improved significantly after training, demonstrated by a shift of the anaerobic threshold to a higher workload (from 32 +/- 5 to 46 +/- 6 W; p=0.003) together with an increase in exercise endurance time (p

U2 - 10.1183/09031936.00027909

DO - 10.1183/09031936.00027909

M3 - Article

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SN - 0903-1936

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