Effects of local hyperthermia on the motor function of the rat sciatic nerve

J Wondergem, J Haveman, V Rusman, P Sminia, J D Van Dijk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The effect of local heat treatment of the sciatic nerve was assessed using the toe-spreading test, which mainly assesses the motor function of the sciatic nerve. A 5 mm long segment of the nerve was heated at temperatures from 42.0 to 45.0 degrees C in vivo using a brass thermode. Hyperthermia led to a decrease in spreading of the toes. Recovery from functional loss took place in all cases, and this recovery was completed in 4 weeks. A 50 per cent functional loss in 50 per cent of the treated animals was observed after 58, 32 and 12 min of heating at 43.0, 44.0 and 45.0 degrees C respectively.

Original languageEnglish
Pages (from-to)429-38
Number of pages10
JournalInternational journal of radiation biology and related studies in physics, chemistry, and medicine
Volume53
Issue number3
Publication statusPublished - Mar 1988

Cite this

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title = "Effects of local hyperthermia on the motor function of the rat sciatic nerve",
abstract = "The effect of local heat treatment of the sciatic nerve was assessed using the toe-spreading test, which mainly assesses the motor function of the sciatic nerve. A 5 mm long segment of the nerve was heated at temperatures from 42.0 to 45.0 degrees C in vivo using a brass thermode. Hyperthermia led to a decrease in spreading of the toes. Recovery from functional loss took place in all cases, and this recovery was completed in 4 weeks. A 50 per cent functional loss in 50 per cent of the treated animals was observed after 58, 32 and 12 min of heating at 43.0, 44.0 and 45.0 degrees C respectively.",
keywords = "Animals, Female, Hot Temperature/adverse effects, Humans, Movement, Muscles/innervation, Rats, Sciatic Nerve/physiology, Toes/physiology",
author = "J Wondergem and J Haveman and V Rusman and P Sminia and {Van Dijk}, {J D}",
year = "1988",
month = "3",
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volume = "53",
pages = "429--38",
journal = "International journal of radiation biology and related studies in physics, chemistry, and medicine",
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Effects of local hyperthermia on the motor function of the rat sciatic nerve. / Wondergem, J; Haveman, J; Rusman, V; Sminia, P; Van Dijk, J D.

In: International journal of radiation biology and related studies in physics, chemistry, and medicine, Vol. 53, No. 3, 03.1988, p. 429-38.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of local hyperthermia on the motor function of the rat sciatic nerve

AU - Wondergem, J

AU - Haveman, J

AU - Rusman, V

AU - Sminia, P

AU - Van Dijk, J D

PY - 1988/3

Y1 - 1988/3

N2 - The effect of local heat treatment of the sciatic nerve was assessed using the toe-spreading test, which mainly assesses the motor function of the sciatic nerve. A 5 mm long segment of the nerve was heated at temperatures from 42.0 to 45.0 degrees C in vivo using a brass thermode. Hyperthermia led to a decrease in spreading of the toes. Recovery from functional loss took place in all cases, and this recovery was completed in 4 weeks. A 50 per cent functional loss in 50 per cent of the treated animals was observed after 58, 32 and 12 min of heating at 43.0, 44.0 and 45.0 degrees C respectively.

AB - The effect of local heat treatment of the sciatic nerve was assessed using the toe-spreading test, which mainly assesses the motor function of the sciatic nerve. A 5 mm long segment of the nerve was heated at temperatures from 42.0 to 45.0 degrees C in vivo using a brass thermode. Hyperthermia led to a decrease in spreading of the toes. Recovery from functional loss took place in all cases, and this recovery was completed in 4 weeks. A 50 per cent functional loss in 50 per cent of the treated animals was observed after 58, 32 and 12 min of heating at 43.0, 44.0 and 45.0 degrees C respectively.

KW - Animals

KW - Female

KW - Hot Temperature/adverse effects

KW - Humans

KW - Movement

KW - Muscles/innervation

KW - Rats

KW - Sciatic Nerve/physiology

KW - Toes/physiology

M3 - Article

VL - 53

SP - 429

EP - 438

JO - International journal of radiation biology and related studies in physics, chemistry, and medicine

JF - International journal of radiation biology and related studies in physics, chemistry, and medicine

SN - 0020-7616

IS - 3

ER -