Efficacy of a physical therapy program in patients with Parkinson's disease: A randomized controlled trial

Terry Ellis; Cees J. De Goede; Robert G. Feldman; Erik C. Wolters; Gert Kwakkel; Robert C. Wagenaar

doi:10.1016/j.apmr.2004.08.008

Efficacy of a physical therapy program in patients with Parkinson's disease: A randomized controlled trial

Terry Ellis^*, Cees J. De Goede, Robert G. Feldman, Erik C. Wolters, Gert Kwakkel, Robert C. Wagenaar

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To investigate the effects of a physical therapy (PT) program in groups of people with Parkinson's disease (PD).

DESIGN: Randomized controlled trial with a crossover design.

SETTING: Two outpatient rehabilitation clinics in Boston and Amsterdam, respectively.

PARTICIPANTS: Sixty-eight subjects diagnosed with typical, idiopathic PD, Hoehn and Yahr stage II or III, and stable medication use.

INTERVENTION: Group A received PT and medication therapy (MT) for the first 6 weeks, followed by MT only for the second 6 weeks. Group B received only MT for the first 6 weeks and PT and MT for the second 6 weeks.

MAIN OUTCOME MEASURES: The Sickness Impact Profile (SIP-68), the mobility portion of the SIP-68, the Unified Parkinson's Disease Rating Scale (UPDRS), and comfortable walking speed (CWS) at baseline, 6-week, 12-week, and 3-month follow-up.

RESULTS: At 6 weeks, differences between groups were significant for the SIP mobility ( P =.015; effect size [ES]=.55), for CWS ( P =.012; ES=.49), for the activities of daily living (ADL) section of the UPDRS ( P =.014; ES=.45), and for the total UPDRS ( P =.007; ES=.56). The total SIP and the mentation and motor sections of the UPDRS did not differ significantly between groups. Significant differences were found at 3 months compared with baseline for CWS, the UPDRS ADL, and total scores.

CONCLUSIONS: People with PD derive benefits in the short term from PT group treatment, in addition to their MT, for quality of life related to mobility, CWS, and ADLs; long-term benefits were found in CWS, UPDRS ADL, and total scores but varied between groups.

Original language	English
Pages (from-to)	626-632
Number of pages	7
Journal	Archives of Physical Medicine and Rehabilitation
Volume	86
Issue number	4
DOIs	https://doi.org/10.1016/j.apmr.2004.08.008
Publication status	Published - 1 Jan 2005

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Ellis, T., De Goede, C. J., Feldman, R. G., Wolters, E. C., Kwakkel, G., & Wagenaar, R. C. (2005). Efficacy of a physical therapy program in patients with Parkinson's disease: A randomized controlled trial. Archives of Physical Medicine and Rehabilitation, 86(4), 626-632. https://doi.org/10.1016/j.apmr.2004.08.008

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title = "Efficacy of a physical therapy program in patients with Parkinson's disease: A randomized controlled trial",

abstract = "OBJECTIVE: To investigate the effects of a physical therapy (PT) program in groups of people with Parkinson's disease (PD).DESIGN: Randomized controlled trial with a crossover design.SETTING: Two outpatient rehabilitation clinics in Boston and Amsterdam, respectively.PARTICIPANTS: Sixty-eight subjects diagnosed with typical, idiopathic PD, Hoehn and Yahr stage II or III, and stable medication use.INTERVENTION: Group A received PT and medication therapy (MT) for the first 6 weeks, followed by MT only for the second 6 weeks. Group B received only MT for the first 6 weeks and PT and MT for the second 6 weeks.MAIN OUTCOME MEASURES: The Sickness Impact Profile (SIP-68), the mobility portion of the SIP-68, the Unified Parkinson's Disease Rating Scale (UPDRS), and comfortable walking speed (CWS) at baseline, 6-week, 12-week, and 3-month follow-up.RESULTS: At 6 weeks, differences between groups were significant for the SIP mobility ( P =.015; effect size [ES]=.55), for CWS ( P =.012; ES=.49), for the activities of daily living (ADL) section of the UPDRS ( P =.014; ES=.45), and for the total UPDRS ( P =.007; ES=.56). The total SIP and the mentation and motor sections of the UPDRS did not differ significantly between groups. Significant differences were found at 3 months compared with baseline for CWS, the UPDRS ADL, and total scores.CONCLUSIONS: People with PD derive benefits in the short term from PT group treatment, in addition to their MT, for quality of life related to mobility, CWS, and ADLs; long-term benefits were found in CWS, UPDRS ADL, and total scores but varied between groups.",

keywords = "Parkinson disease, Physical therapy, Randomized controlled trials, Rehabilitation",

author = "Terry Ellis and {De Goede}, {Cees J.} and Feldman, {Robert G.} and Wolters, {Erik C.} and Gert Kwakkel and Wagenaar, {Robert C.}",

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Efficacy of a physical therapy program in patients with Parkinson's disease : A randomized controlled trial. / Ellis, Terry; De Goede, Cees J.; Feldman, Robert G.; Wolters, Erik C.; Kwakkel, Gert; Wagenaar, Robert C.

In: Archives of Physical Medicine and Rehabilitation, Vol. 86, No. 4, 01.01.2005, p. 626-632.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Efficacy of a physical therapy program in patients with Parkinson's disease

T2 - A randomized controlled trial

AU - Ellis, Terry

AU - De Goede, Cees J.

AU - Feldman, Robert G.

AU - Wolters, Erik C.

AU - Kwakkel, Gert

AU - Wagenaar, Robert C.

PY - 2005/1/1

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N2 - OBJECTIVE: To investigate the effects of a physical therapy (PT) program in groups of people with Parkinson's disease (PD).DESIGN: Randomized controlled trial with a crossover design.SETTING: Two outpatient rehabilitation clinics in Boston and Amsterdam, respectively.PARTICIPANTS: Sixty-eight subjects diagnosed with typical, idiopathic PD, Hoehn and Yahr stage II or III, and stable medication use.INTERVENTION: Group A received PT and medication therapy (MT) for the first 6 weeks, followed by MT only for the second 6 weeks. Group B received only MT for the first 6 weeks and PT and MT for the second 6 weeks.MAIN OUTCOME MEASURES: The Sickness Impact Profile (SIP-68), the mobility portion of the SIP-68, the Unified Parkinson's Disease Rating Scale (UPDRS), and comfortable walking speed (CWS) at baseline, 6-week, 12-week, and 3-month follow-up.RESULTS: At 6 weeks, differences between groups were significant for the SIP mobility ( P =.015; effect size [ES]=.55), for CWS ( P =.012; ES=.49), for the activities of daily living (ADL) section of the UPDRS ( P =.014; ES=.45), and for the total UPDRS ( P =.007; ES=.56). The total SIP and the mentation and motor sections of the UPDRS did not differ significantly between groups. Significant differences were found at 3 months compared with baseline for CWS, the UPDRS ADL, and total scores.CONCLUSIONS: People with PD derive benefits in the short term from PT group treatment, in addition to their MT, for quality of life related to mobility, CWS, and ADLs; long-term benefits were found in CWS, UPDRS ADL, and total scores but varied between groups.

AB - OBJECTIVE: To investigate the effects of a physical therapy (PT) program in groups of people with Parkinson's disease (PD).DESIGN: Randomized controlled trial with a crossover design.SETTING: Two outpatient rehabilitation clinics in Boston and Amsterdam, respectively.PARTICIPANTS: Sixty-eight subjects diagnosed with typical, idiopathic PD, Hoehn and Yahr stage II or III, and stable medication use.INTERVENTION: Group A received PT and medication therapy (MT) for the first 6 weeks, followed by MT only for the second 6 weeks. Group B received only MT for the first 6 weeks and PT and MT for the second 6 weeks.MAIN OUTCOME MEASURES: The Sickness Impact Profile (SIP-68), the mobility portion of the SIP-68, the Unified Parkinson's Disease Rating Scale (UPDRS), and comfortable walking speed (CWS) at baseline, 6-week, 12-week, and 3-month follow-up.RESULTS: At 6 weeks, differences between groups were significant for the SIP mobility ( P =.015; effect size [ES]=.55), for CWS ( P =.012; ES=.49), for the activities of daily living (ADL) section of the UPDRS ( P =.014; ES=.45), and for the total UPDRS ( P =.007; ES=.56). The total SIP and the mentation and motor sections of the UPDRS did not differ significantly between groups. Significant differences were found at 3 months compared with baseline for CWS, the UPDRS ADL, and total scores.CONCLUSIONS: People with PD derive benefits in the short term from PT group treatment, in addition to their MT, for quality of life related to mobility, CWS, and ADLs; long-term benefits were found in CWS, UPDRS ADL, and total scores but varied between groups.

KW - Parkinson disease

KW - Physical therapy

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