Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project

Andrea Correa-Pérez, Iosef Abraha, Antonio Cherubini, Avril Collinson, Dominique Dardevet, Lisette C. P. G. M. de Groot, Marian A. E. de van der Schueren, Antje Hebestreit, Mary Hickson, Javier Jaramillo-Hidalgo, Isabel Lozano-Montoya, Denis O'Mahony, Roy L. Soiza, Marjolein Visser, Dorothee Volkert, Maike Wolters, Alfonso J. Cruz Jentoft

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. Results: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. Conclusions: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.
LanguageEnglish
Pages27-48
JournalAgeing Research Reviews
Volume49
DOIs
StatePublished - 2019

Cite this

Correa-Pérez, Andrea ; Abraha, Iosef ; Cherubini, Antonio ; Collinson, Avril ; Dardevet, Dominique ; de Groot, Lisette C. P. G. M. ; de van der Schueren, Marian A. E. ; Hebestreit, Antje ; Hickson, Mary ; Jaramillo-Hidalgo, Javier ; Lozano-Montoya, Isabel ; O'Mahony, Denis ; Soiza, Roy L. ; Visser, Marjolein ; Volkert, Dorothee ; Wolters, Maike ; Jentoft, Alfonso J. Cruz. / Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project. In: Ageing Research Reviews. 2019 ; Vol. 49. pp. 27-48
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title = "Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project",
abstract = "Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. Results: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95{\%}CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95{\%}CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. Conclusions: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.",
author = "Andrea Correa-P{\'e}rez and Iosef Abraha and Antonio Cherubini and Avril Collinson and Dominique Dardevet and {de Groot}, {Lisette C. P. G. M.} and {de van der Schueren}, {Marian A. E.} and Antje Hebestreit and Mary Hickson and Javier Jaramillo-Hidalgo and Isabel Lozano-Montoya and Denis O'Mahony and Soiza, {Roy L.} and Marjolein Visser and Dorothee Volkert and Maike Wolters and Jentoft, {Alfonso J. Cruz}",
year = "2019",
doi = "10.1016/j.arr.2018.10.011",
language = "English",
volume = "49",
pages = "27--48",
journal = "Ageing Research Reviews",
issn = "1568-1637",
publisher = "Elsevier Ireland Ltd",

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Correa-Pérez, A, Abraha, I, Cherubini, A, Collinson, A, Dardevet, D, de Groot, LCPGM, de van der Schueren, MAE, Hebestreit, A, Hickson, M, Jaramillo-Hidalgo, J, Lozano-Montoya, I, O'Mahony, D, Soiza, RL, Visser, M, Volkert, D, Wolters, M & Jentoft, AJC 2019, 'Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project' Ageing Research Reviews, vol. 49, pp. 27-48. DOI: 10.1016/j.arr.2018.10.011

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project. / Correa-Pérez, Andrea; Abraha, Iosef; Cherubini, Antonio; Collinson, Avril; Dardevet, Dominique; de Groot, Lisette C. P. G. M.; de van der Schueren, Marian A. E.; Hebestreit, Antje; Hickson, Mary; Jaramillo-Hidalgo, Javier; Lozano-Montoya, Isabel; O'Mahony, Denis; Soiza, Roy L.; Visser, Marjolein; Volkert, Dorothee; Wolters, Maike; Jentoft, Alfonso J. Cruz.

In: Ageing Research Reviews, Vol. 49, 2019, p. 27-48.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project

AU - Correa-Pérez,Andrea

AU - Abraha,Iosef

AU - Cherubini,Antonio

AU - Collinson,Avril

AU - Dardevet,Dominique

AU - de Groot,Lisette C. P. G. M.

AU - de van der Schueren,Marian A. E.

AU - Hebestreit,Antje

AU - Hickson,Mary

AU - Jaramillo-Hidalgo,Javier

AU - Lozano-Montoya,Isabel

AU - O'Mahony,Denis

AU - Soiza,Roy L.

AU - Visser,Marjolein

AU - Volkert,Dorothee

AU - Wolters,Maike

AU - Jentoft,Alfonso J. Cruz

PY - 2019

Y1 - 2019

N2 - Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. Results: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. Conclusions: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

AB - Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts. Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Quality assessment was undertaken using Cochrane and GRADE criteria. Results: Eighteen primary studies from seventeen SRs were included. Eleven RCTs compared oral nutritional supplementation (ONS) with usual care. No beneficial effects of ONS treatment, after performing two meta-analysis in body weight changes (six studies), mean difference: 0.59 (95%CI -0.08, 1.96) kg, and in body mass index changes (two studies), mean difference: 0.31 (95%CI -0.17, 0.79) kg/m2 were found. Neither in MNA scores, muscle strength, activities of daily living, timed Up&Go, quality of life and mortality. Results of other intervention studies (dietary counselling and ONS, ONS combined with exercise, nutrition delivery systems) were inconsistent. The overall quality of the evidence was very low due to risk of bias and small sample size. Conclusions: This review has highlighted the lack of high quality evidence to indicate which interventions are effective in treating malnutrition in older people. High quality research studies are urgently needed in this area.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30391755

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DO - 10.1016/j.arr.2018.10.011

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SP - 27

EP - 48

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T2 - Ageing Research Reviews

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SN - 1568-1637

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